How should this medicine be used?
Pletmol comes as a tablet to take by mouth. It is usually taken twice a day, at least 30 minutes before or 2 hours after breakfast and dinner. Take Pletmol at around the same times every day. Follow the directions on the prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Pletmol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Pletmol controls the symptoms of intermittent claudication but does not cure it. Although you may notice improvements in 2 to 4 weeks, it may take up to 12 weeks before you notice the full benefit (increased walking distance) of Pletmol. Continue taking Pletmol even if you feel well. Do not stop taking Pletmol without talking to your doctor.
Pletmol is a quinolinone derivative that inhibits specific cellular phosphadiesterases, which cause arterial vasodilation and inhibition of platelet function and makes it a valuable as a therapy of intermittent claudication and as a means of secondary prevention of stroke. Pletmol has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury.
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PLETAL ® (Pletmol) Tablets
CONTRAINDICATED IN HEART FAILURE PATIENTS
PLETAL is contraindicated in patients with heart failure of any severity. Pletmol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III-IV heart failure .
How to use Pletmol
Read the Patient Information Leaflet if available from your pharmacist before you start taking Pletmol and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth without food as directed by your doctor, usually twice daily, at least 30 minutes before or 2 hours after breakfast and dinner. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Use this medication regularly to get the most benefit from it. Remember to use it at the same times each day.
Your symptoms may improve in 2-4 weeks, but it may take up to 12 weeks before you get the full benefit of this drug.
Tell your doctor if your condition persists or worsens.
The total and unbound oral clearances, adjusted for body weight, of Pletmol and its metabolites were not significantly different with respect to age (50 to 80 years) or gender.
Pletmol did not inhibit the pharmacologic effects (PT, aPTT, bleeding time, or platelet aggregation) of R-and S-warfarin after a single 25-mg dose of warfarin. The effect of concomitant multiple dosing of warfarin and PLETAL on the pharmacodynamics of both drugs is unknown.
ВїPara cuГЎles condiciones o enfermedades se prescribe este medicamento?
El Pletmol se usa para reducir los sГntomas de la claudicaciГіn intermitente (dolor en las piernas que empeora al caminar y mejora al estar en reposo, provocado por el estrechamiento de los vasos sanguГneos que irrigan sangre a las piernas). El Pletmol pertenece a una clase de medicamentos llamados inhibidores de la agregaciГіn plaquetaria (medicamentos antiplaquetarios). ActГєa mejorando el flujo de sangre a las piernas.
Where can I get more information?
Your pharmacist can provide more information about Pletmol.
Pletmol dosing information
Usual Adult Dose for Intermittent Claudication:
100 mg orally twice a day at least 30 minutes before or 2 hours after breakfast and dinner
Comments:-Patients may respond as early as 2 to 4 weeks after initiation of therapy, but treatment for up to 12 weeks may be required before a beneficial effect is experienced.-If symptoms remain unimproved after 3 months, discontinue this drug.
Use: Reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance.
Medicamentos similares al Pletmol provocaron un mayor riesgo de muerte en pacientes con insuficiencia cardГaca congestiva (afecciГіn en la que el corazГіn no puede bombear una cantidad suficiente de sangre a las demГЎs partes del cuerpo). DГgale a su mГ©dico si tiene o ha tenido insuficiencia cardГaca congestiva. Probablemente su mГ©dico le diga que no tome Pletmol.
Consulte a su mГ©dico sobre los riesgos de tomar Pletmol.