Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Heart attack. Symptoms can include:
- chest pain that spreads to your shoulder or arm
- excessive sweating
- shortness of breath
- severe chest pain
- fast heart rate
- irregular heart beat
- palpitations (feeling like your heart is skipping beats)
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
MyGran oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
What Are Side Effects Associated with Using MyGran?
Side effects associated with use of MyGran, include the following:
- Injection site reaction
- Numbness and tingling
- Warm/hot sensation
- Chest discomfort/pressure/tightness
- Jaw or neck tightness
- Increased sweating
- Burning sensation
- Cold sensation
- Difficulty swallowing
- Sore throat
- Feeling unwell (malaise)
- Abdominal distress
Other side effects of MyGran include:
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Drugs you should not use with MyGran
Do not take these drugs with MyGran. Doing so can cause dangerous effects in the body. Examples of these drugs include:
- Monoamine oxidase-A inhibitors (MAOIs), such as phenelzine, isocarboxazid, or tranylcypromine. Taking these drugs with MyGran can cause a severe condition called serotonin syndrome. Symptoms can include agitation, sweating, fast heartbeat, or hallucinations (seeing or hearing things that aren’t real). They can also include nausea, vomiting, diarrhea, or loss of balance.
- Ergot-containing drugs, such as dihydroergotamine or methysergide. Taking these drugs with MyGran raises your risk of certain side effects, such as tightness or pressure in your chest. Don’t take these medications if you’ve taken MyGran in the last 24 hours.
- Other serotonin-1 receptor agonists, such as almotriptan or zolmitriptan. Taking these drugs with MyGran raises your risk of certain side effects, such as tightness or pressure in your chest. Don’t take these medications if you’ve taken MyGran in the last 24 hours.
Before using MyGran, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (for example, in your legs, arms/hands, or stomach), certain types of headaches (hemiplegic or basilar migraine), heart problems (such as chest pain, irregular heartbeat, previous heart attack), liver disease, seizure, stroke or "mini-stroke" (transient ischemic attack).
Certain conditions can increase your risk for heart problems. Tell your doctor if you have any of these conditions, including: high blood pressure, high cholesterol, diabetes, family history of heart disease, overweight, smoker, postmenopausal (women), age more than 40 years (men).
This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
The risk of heart disease, liver disease, and high blood pressure increases with age. Older adults may be more sensitive to the side effects of this drug, especially increased blood pressure and heart problems.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This drug passes into breast milk in small amounts. Consult your doctor before breast-feeding.
Flushing, feelings of tingling/numbness/prickling/heat, tiredness, weakness, drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.
Tell your doctor right away if you have any serious side effects, including: blue fingers/toes/nails, cold hands/feet, hearing changes, mental/mood changes.
MyGran can commonly cause chest/jaw/neck tightness, pain, or pressure that is usually not serious. However, these side effects are like symptoms of a heart attack, which may include chest/jaw/left arm pain, shortness of breath, or unusual sweating. Get medical help right away if these or other serious side effects occur, including: fast/irregular heartbeat, fainting, severe stomach/abdominal pain, bloody diarrhea, seizure, signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion).
This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
What is MyGran? What are the uses for MyGran?
MyGran is a drug that is used for treating migraine headaches. It belongs to a class of drugs called selective serotonin receptor agonists. Other members of this class include naratriptan (Amerge), zolmitriptan (Zomig), rizatriptan (Maxalt), frovatriptan (Frova), eletriptan (Relpax), and almotriptan (Axert).
Migraine headaches are believed to result from dilatation of blood vessels in the brain. MyGran relieves migraines by stimulating serotonin receptors in the brain which cause the muscles surrounding the blood vessels in the brain to contract and narrow the blood vessels. At the same time, it also reduces transmission of pain signals by nerves to the brain. While it is very effective in relieving migraine headaches, it does not prevent or reduce the number of headaches. The FDA approved MyGran in December 1992.
History and Etymology for MyGran
perhaps from suma- (by shortening & alteration from sulfonam >-triptan (by shortening & alteration from tryptamine)
How to use MyGran Succinate
Read the Patient Information Leaflet if available from your pharmacist before you start taking MyGran and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, at the first sign of a migraine. The dosage is based on your medical condition and response to treatment. If there is no improvement in your symptoms, do not take more doses of this medication before talking to your doctor. If your symptoms are only partly relieved, or if your headache comes back, you may take another dose at least two hours after the first dose. Do not take more than 200 milligrams in a 24-hour period.
This medication may also be used as a backup for MyGran injection. If your symptoms are only partly relieved or your headache comes back, you may take a dose of MyGran by mouth at least two hours after the injection, up to a maximum of 100 milligrams in a 24-hour period.
If you have a higher risk for heart problems (see Precautions), your doctor may perform a heart exam before you start taking MyGran. He/she may also direct you to take your first dose of this medication in the office/clinic to monitor for serious side effects (such as chest pain). Talk to your doctor for details.
If you are using drugs for migraine attacks on 10 or more days each month, the drugs may actually make your headaches worse (medication overuse headache). Do not use medications more often or for longer than directed. Tell your doctor if you need to use this medication more often, or if the medication is not working as well, or if your headaches get worse.
- Heart attack: This drug can cause serious heart problems such as heart attack, angina (chest pain), or cardiac arrest. If you’re at risk for heart disease, your doctor may have you take your first dose in their office so they can monitor you.
- Arrhythmias: This drug may cause your heart rhythm to change, which can be dangerous. If you feel changes in the way your heart beats, stop taking this drug and call your doctor right away.
- Chest, throat, neck, or jaw pain: This drug can cause tightness, pain, or pressure in your chest, throat, neck, or jaw. In general, this feeling can be a symptom of heart attack, but it may not be when you’re taking this drug. If you have this symptom, call your doctor.
- Brain hemorrhage or stroke: Severe bleeding in the brain (brain hemorrhage) or stroke can occur if you take this drug. It’s not clear if MyGran is a direct cause of these effects.
MyGran oral tablet is a prescription drug that’s available as the brand-name drug Imitrex. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.
MyGran also comes in a nasal spray, an injectable solution, or a nasal powder.