Mechanism of Action
Moxam has analgesic, anti-inflammatory, and antipyretic properties.
The mechanism of action of Moxam, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Moxam is a potent inhibitor of prostaglandin synthesis in vitro . Moxam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Moxam is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Generally speaking, the daily recommended dose of Moxam is 7.5 mg.
Your doctor may increase the dosage to 15 mg.
Moxam should be taken exactly as prescribed, at the lowest dose possible for your treatment and for the shortest time needed.
Take Moxam with a glass of water. Swallow the pill whole; don't chew it or let it melt/dissolve in your mouth.
Take Moxam with or without food. Taking it with food can help prevent an upset stomach.
Also, wait at least 30 minutes after taking Moxam before lying down to help prevent an upset stomach.
What is Moxam, and how does it work (mechanism of action)?
Moxam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to treat pain and/or inflammation. Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. Prostaglandins are chemicals that contribute to inflammation especially within joints, and it is the inflammation that leads to the common symptoms of pain, tenderness, and swelling associated with arthritis. Moxam blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and reduces the levels of prostaglandins. As a result, inflammation and its accompanying symptoms are reduced. Moxam was approved for use in April 2000.
How to use Moxam
Read the Medication Guide provided by your pharmacist before you start taking Moxam and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually once daily. Drink a full glass of water (8 ounces/240 milliliters) with it unless your doctor tells you otherwise. Do not lie down for at least 10 minutes after taking this drug.
If you are taking the liquid form of this medication, shake the bottle gently before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
If you are taking the disintegrating tablet, do not remove the tablet from the packaging until you are ready to take it. With dry hands, peel back the foil to carefully remove the tablet. Do not push the tablet through the foil because doing so can damage it. Place the tablet on your tongue right away and allow it to dissolve. After the tablet has melted, it can be swallowed with or without liquid.
If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. The dosage is based on your medical condition and response to treatment. The lowest effective dosage should always be used, and only for the prescribed length of time. Do not take more of this medication than prescribed because higher doses increase the chance of stomach ulcers/bleeding.
Moxam may come in different forms (such as tablet, capsule, liquid, disintegrating tablet). Do not switch between different forms without consulting your doctor.
It may take up to two weeks before you get the full benefit of this drug. Use this medication regularly to get the most benefit from it. Remember to use it at the same time each day.
Tell your doctor if your condition worsens.
Moxam is used to treat tenderness, swelling, and pain caused by the inflammation of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis in patients 2 years of age or older.
- Individuals who are allergic to NSAIDs may experience shortness of breath when given an NSAID. People with asthma also are at a higher risk for experiencing serious allergic reaction to NSAIDs. Individuals with a serious allergy to one NSAID are likely to experience a similar reaction to a different NSAID.
- New onset or worsening of high blood pressure (hypertension) may occur. Blood pressure should be monitored closely during treatment.
- Moxam may cause fluid retention and swelling (edema). It should be used cautiously in people with heart failure.
- Moxam may reduce kidney function. Therefore, it should not be used in people with severe kidney failure. It should be used cautiously in the elderly, people with heart failure, liver dysfunction, and those taking diuretics, ACE-inhibitors, or angiotensin II antagonists.
- Serious skin reactions such as exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis (TEN) may occur without warning.
- NSAIDs (except low dose aspirin) may increase the risk of potentially fatal heart attacks, stroke, and related conditions in people with or without heart disease or risk factors for heart disease. The increased risk of heart attack or stroke may occur as early as the first week of use and the risk may increase with longer use and is higher in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.
- Central nervous system effects including drowsiness, dizziness, and blurred vision may occur in patients who are taking an NSAIDs.