Movalis tablets

Movalis

  • Active Ingredient: Meloxicam
  • 15 mg, 7.5 mg
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What is Movalis?

The active ingredient of Movalis brand is meloxicam. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID). Meloxicam works by reducing hormones that cause inflammation and pain in the body.

Used for

Movalis is used to treat diseases such as: Fibromyalgia, Inflammatory Conditions, Juvenile Rheumatoid Arthritis, Osteoarthritis, Rheumatoid Arthritis, Tendonitis.

Side Effect

Possible side effects of Movalis include: gas; blurred vision; painful or difficult urination; sudden onset of slurred speech; severe stomach pain; slow or fast heartbeat; tenderness in the stomach area.

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The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.

Anticoagulant activity should be monitored, particularly in the first few days after initiating or changing Movalis tablets therapy in patients receiving warfarin or similar agents, since these patients are at an increased risk of bleeding. The effect of Movalis on the anticoagulant effect of warfarin was studied in a group of healthy subjects receiving daily doses of warfarin that produced an INR (International Normalized Ratio) between 1.2 and 1.8. In these subjects, Movalis did not alter warfarin pharmacokinetics and the average anticoagulant effect of warfarin as determined by prothrombin time. However, one subject showed an increase in INR from 1.5 to 2.1. Caution should be used when administering Movalis tablets with warfarin since patients on warfarin may experience changes in INR and an increased risk of bleeding complications when a new medication is introduced.

Allergy warning

Don’t take Movalis if you’ve had itchy skin, symptoms of asthma, or an allergic reaction to aspirin or other NSAIDs. A second reaction could be much more severe.

Outcome and Management

Severity ranges from asymptomatic elevations in serum aminotransferase levels, to symptomatic hepatitis with or without jaundice. Fatal and chronic cases have not been described. Although cross sensitivity has not been shown, patients with clinically apparent Movalis induced liver injury should probably avoid other oxicam NSAIDs such as piroxicam.

Is Movalis Addictive?

The continuing problems caused by the opioid epidemic have led to doctors and researchers looking for nonaddictive alternatives to treating chronic or severe pain. One name that has come up is Movalis, a nonsteroidal anti-inflammatory drug (NSAID) that is used in pain and inflammation therapy. In the quest to come up with safer pharmaceutical options, we take a look at whether Movalis is dangerous or addictive.

Frequently Asked Questions About Movalis:

Rated Movalis for Moderate Pain Report

Started taking Movalis 15mg daily about two weeks ago. One week into taking it, the pain was totally gone--I have arthritis in my lower back and brusitis in my hip--all on the left side. But. I have a history of moderate to severe depression and this makes me depressed more than usual and feel not myself. I also feel sick like having the stomach flu. I like this medicine because the pain is gone and other meds like ibuprofen, Tylenol, and aleve don't touch the pain. Yet, I am afraid I am going to have a relapse of major depression. I don't know what to do.

Q: Does Movalis interact with any of the 'statin' drugs?

A: According to the package insert, studies have not shown a drug interaction between Movalis (Mobic) and the 'statin' drugs, such as Zocor (simvastatin), Lescol (fluvastatin) and Crestor (rosuvastatin). However, it is important to note that both drugs can cause liver problems and patients should be aware of the signs and symptoms of liver damage, which include nausea, fatigue, lethargy, itchy skin, jaundice or yellowing of the eyes or skin, abdominal pain on the right side, and "flu-like" symptoms. If any of these occur, please seek medical care immediately. For more information, please consult with your healthcare practitioner. Michelle McDermott, PharmD

Precautionary Steps for Movalis

Let your doctor know off any allergies before taking Movalis; or to headache medicine or different NSAIDs, (for example, ibuprofen, naproxen, celecoxib). This item may contain ingredients, which can cause allergies or other issues. Consult with your pharmacist for all specifications of the product.

Prior to use this medication, tell your doctor or drug specialist your medical history, particularly of: asthma (counting a past filled with worsening breathing after taking headache medicine or different NSAIDs), liver sickness, stomach/digestive system/throat issues, (for example, bleeding, ulcers, repeating recurring heartburn), heart related diseases, (for example, history of heart attacks), hypertension, stroke, blood related issues, (for example, anemia, bleeding/coagulating issues), developments in the nose (nasal polyps).

Kidney issues can here and there happen with the utilization of NSAID meds, including Movalis. Issues are bound to happen in the event that you are dried out, have heart failure or kidney related diseases, are an older adult, or on the off chance that you take certain meds. Drink a lot of liquids as guided by the doctor to anticipate lack of hydration and tell your doctor immediately in the event that you have change in the volume of pee.

This medication may make you feel dizziness. Liquor or weed can make you progressively more dizzy. Try not to drive, use apparatus, or do whatever needs readiness until you can do it safely. Consult with your doctor in the event that you are using marijuana.

This prescription may cause stomach bleeding. Daily consumption of liquor and tobacco, particularly when used with this medication, may increase your hazard for stomach bleeding. Best practice is to limit the use liquor and smoking. For any more query consult your doctor on what to intake.

Juvenile Rheumato > Movalis tablets are indicated for relief of the signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumato >see Dosage and Administration (2.4) and Clinical Studies (14.2) ].

What are ibuprofen and Movalis? How do they work?

Ibuprofen (Advil, Motrin) and Movalis (Mobic) belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include indomethacin (Indocin), nabumetone (Relafen), and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. NSAIDs work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation.

Ibuprofen and Movalis block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. Consequently, inflammation, pain, and fever are reduced.

How Supplied/Storage and Handling

Movalis Tablets USP, 7.5 mg are yellow, round-shaped, flat beveled edge, uncoated tablets debossed with 'ZC' and '25' on one side and plain on other side and are supplied as follows:

NDC 68382-050-16 in bottles of 90 tablets

NDC 68382-050-01 in bottles of 100 tablets

NDC 68382-050-05 in bottles of 500 tablets

NDC 68382-050-40 in bottles of 5000 tablets

NDC 68382-050-77 in unit-dose blister cartons of 100 (10 x 10) unit-dose tablets

Movalis Tablets USP, 15 mg are yellow, round-shaped, flat beveled edge, uncoated tablet debossed with 'ZC' and '26' on one side and plain on other side and are supplied as follows:

NDC 68382-051-16 in bottles of 90 tablets

NDC 68382-051-01 in bottles of 100 tablets

NDC 68382-051-05 in bottles of 500 tablets

NDC 68382-051-40 in bottles of 5000 tablets

NDC 68382-051-77 in unit-dose blister cartons of 100 (10 x 10) unit-dose tablets

Store at 20° to 25° C (68° to 77° F) . Keep Movalis tablets in a dry place.

Dispense tablets in a tight container.

Keep this and all medications out of the reach of children.

Table 1b Adverse Events (%) Occurring in ≥ 2% of Movalis Patients in two 12-Week Rheumatoid Arthritis Placebo-Controlled Trials Placebo Movalis 7 . 5 mg daily Movalis 15 mg daily
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Non-Interchangeability with Other Formulations of Movalis

Movalis tablets have not shown equivalent systemic exposure to other approved formulations of oral Movalis. Therefore, Movalis tablets are not interchangeable with other formulations of oral Movalis product even if the total milligram strength is the same. Do not substitute similar dose strengths of Movalis tablets with other formulations of oral Movalis product.

When a Movalis is administered with aspirin (1000 mg TID) to healthy volunteers, it tended to increase the AUC (10%) and Cmax (24%) of Movalis. The clinical significance of this interaction is not known; however, as with other NSAIDs concomitant administration of Movalis and aspirin is not generally recommended because of the potential for increased adverse effects.

Concomitant administration of low-dose aspirin with Movalis tablets may result in an increased rate of GI ulceration or other complications, compared to use of Movalis tablets alone. Movalis tablet is not a substitute for aspirin for cardiovascular prophylaxis.

Advanced Renal Disease

No information is available from controlled clinical studies regarding the use of Movalis tablets in patients with advanced renal disease. Therefore, treatment with Movalis tablet is not recommended in these patients with advanced renal disease. If Movalis tablets therapy must be initiated, close monitoring of the patient's renal function is advisable.

Masking of Inflammation and Fever

The pharmacological activity of Movalis in reducing inflammation, and possibly fever, may diminish the utility of diagnostic signs in detecting infections.

1 MedDRA high level term (preferred terms): dyspeptic signs and symptoms (dyspepsia, dyspepsia aggravated, eructation, gastrointestinal irritation), upper respiratory tract infections-pathogen unspecified (laryngitis NOS, pharyngitis NOS, sinusitis NOS), joint related signs and symptoms (arthralgia, arthralgia aggravated, joint crepitation, joint effusion, joint swelling)

2 MedDRA preferred term: nausea, abdominal pain NOS, influenza-like illness, headaches NOS, and rash NOS

No . of Patients 469 481 477 Gastrointestinal Disorders 14.1 18.9 16.8 Abdominal pain NOS 2 0.6 2.9 2.3 Dyspeptic signs and symptoms 1 3.8 5.8 4.0 Nausea 2 2.6 3.3 3.8 General Disorders and Administration Site Conditions Influenza-like illness 2 2.1 2.9 2.3 Infection and Infestations Upper respiratory tract infections-pathogen >1 4.1 7.0 6.5 Musculoskeletal and Connective Tissue Disorders Joint related signs and symptoms 1 1.9 1.5 2.3 Nervous System Disorders Headaches NOS 2 6.4 6.4 5.5 Skin and Subcutaneous Tissue Disorders Rash NOS 2 1.7 1.0 2.1

The adverse events that occurred with Movalis in ≥2% of patients treated short-term (4 to 6 weeks) and long-term (6 months) in active-controlled osteoarthritis trials are presented in Table 2


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