Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. Studies with furosemide agents and Mexpharm have not demonstrated a reduction in natriuretic effect. Furosemide single and multiple dose pharmacodynamics and pharmacokinetics are not affected by multiple doses of Mexpharm. Nevertheless, during concomitant therapy with Mexpharm tablets, patients should be observed closely for signs of declining renal failure (see WARNINGS, Renal Effects), as well as to assure diuretic efficacy.
Bipolar disorder medication
Taking lithium with Mexpharm can cause amounts of lithium in your blood to increase to dangerous levels. Symptoms of lithium toxicity may include tremors, excessive thirst, or confusion. If you take these drugs together, your doctor may monitor your lithium levels.
Rated Mexpharm for Moderate Pain Report
Started taking Mexpharm 15mg daily about two weeks ago. One week into taking it, the pain was totally gone--I have arthritis in my lower back and brusitis in my hip--all on the left side. But. I have a history of moderate to severe depression and this makes me depressed more than usual and feel not myself. I also feel sick like having the stomach flu. I like this medicine because the pain is gone and other meds like ibuprofen, Tylenol, and aleve don't touch the pain. Yet, I am afraid I am going to have a relapse of major depression. I don't know what to do.
Carcinogenesis, Mutagenesis, Impairment of Fertility
There was no increase in tumor incidence in long-term carcinogenicity studies in rats (104 weeks) and mice (99 weeks) administered Mexpharm at oral doses up to 0.8 mg/kg/day in rats and up to 8.0 mg/kg/day in mice (up to 0.5-and 2.6-times, respectively, the maximum recommended human dose of 15 mg/day Mexpharm based on body surface area comparison).
Mexpharm was not mutagenic in an Ames assay, or clastogenic in a chromosome aberration assay with human lymphocytes and an in vivo micronucleus test in mouse bone marrow.
Impairment of Fertility
Mexpharm did not impair male and female fertility in rats at oral doses up to 9 mg/kg/day in males and 5 mg/kg/day in females (up to 5.8- and 3.2-times greater, respectively, than the MRHD based on BSA comparison).
In a study conducted in healthy subjects, mean pre-dose lithium concentration and AUC were increased by 21% in subjects receiving lithium doses ranging from 804 to 1072 mg BID with Mexpharm 15 mg QD as compared to subjects receiving lithium alone. These effects have been attributed to inhibition of renal prostaglandin synthesis by Mexpharm tablets patients on lithium treatment should be closely monitored for signs of lithium toxicity when Mexpharm tablets is introduced, adjusted, or withdrawn.