How should this medicine be used?
Meloxibell comes as a tablet and suspension (liquid) to take by mouth. It is usually taken once a day with or without food. Take Meloxibell at the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Meloxibell exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the suspension well before each use to mix the medication evenly.
Advanced Renal Disease
No information is available from controlled clinical studies regarding the use of Meloxibell tablets in patients with advanced renal disease. Therefore, treatment with Meloxibell tablet is not recommended in these patients with advanced renal disease. If Meloxibell tablets therapy must be initiated, close monitoring of the patient's renal function is advisable.
Carcinogenesis, Mutagenesis, Impairment of Fertility
There was no increase in tumor incidence in long-term carcinogenicity studies in rats (104 weeks) and mice (99 weeks) administered Meloxibell at oral doses up to 0.8 mg/kg/day in rats and up to 8.0 mg/kg/day in mice (up to 0.5-and 2.6-times, respectively, the maximum recommended human dose of 15 mg/day Meloxibell based on body surface area comparison).
Meloxibell was not mutagenic in an Ames assay, or clastogenic in a chromosome aberration assay with human lymphocytes and an in vivo micronucleus test in mouse bone marrow.
Impairment of Fertility
Meloxibell did not impair male and female fertility in rats at oral doses up to 9 mg/kg/day in males and 5 mg/kg/day in females (up to 5.8- and 3.2-times greater, respectively, than the MRHD based on BSA comparison).
Rated Meloxibell for Osteoarthritis Report
My doc put me on Meloxibell for osteoarthritis a little over a month ago. I am taking a single dose of 7.5 mg daily. It has helped tremendously with my joint pain. But, about 2 weeks ago I started developing severe headaches on a daily basis. Five days ago I wound up in the emergency room because I was having trouble breathing, stomach cramps, nausea, vomiting, diarrhea, loss of appetite and taste, blurred vision, dizziness, numbness and tingling in my hands, arms and chest, rapid heartbeat, chest pain, mind fog, and trouble concentrating. I thought I was going to have a heart attack or stroke and really felt like I was going to die! I have had 2 more of these episodes since taking this drug. No more! This drug is very dangerous and should be banned! I wish I had done more research before taking this drug.
Does anyone know how to wean off of Meloxibell or can you just stop taking it like Ibuprofen & take?
Updated 26 Jul 2018 • 2 answers
Gastrointestinal Bleeding, Ulceration, and Perforation
NSAIDs, including Meloxibell, can cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs. Only one in five patients who develop a serious upper GI adverse event on NSAID therapy is symptomatic. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occurred in approximately 1% of patients treated for 3-6 months, and in about 2-4% of patients treated for one year. However, even short-term NSAID therapy is not without risk.
Risk Factors for GI Bleeding, Ulceration, and Perforation
Patients with a prior history of peptic ulcer disease and/or GI bleeding who used NSAIDs had a greater than 10-fold increased risk for developing a GI bleed compared to patients without these risk factors. Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. Most postmarketing reports of fatal GI events occurred in elderly or debilitated patients. Additionally, patients with advanced liver disease and/or coagulopathy are at increased risk for GI bleeding.
Strategies to Minimize the GI Risks in NSAID-treated patients :
- Use the lowest effective dosage for the shortest possible duration.
- Avo >see Drug Interactions (7) ].
Bipolar disorder medication
Taking lithium with Meloxibell can cause amounts of lithium in your blood to increase to dangerous levels. Symptoms of lithium toxicity may include tremors, excessive thirst, or confusion. If you take these drugs together, your doctor may monitor your lithium levels.
Other uses for this medicine
Meloxibell is also used sometimes to treat ankylosing spondylitis (arthritis that mainly affects the spine). Talk to your doctor about the possible risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
If you have had an asthma attack, hives, or other allergic-like reactions after taking aspirin or any other NSAID, you should not use Meloxibell.
Be sure to let your doctor know if you have had any of those problems in the past.
Never use Meloxibell right before or after undergoing a heart surgery called a coronary artery bypass graft (CABG).
You also may not be a candidate for this drug if you've had ulcers, stomach bleeding, or severe kidney or liver problems.
Keep in mind that stomach ulcers and stomach bleeding can occur at any time during treatment with any NSAID, including Meloxibell.
Be aware that stomach ulcers and bleeding can occur without warning symptoms, and may cause death.
The chance of developing a stomach ulcer or gastrointestinal bleeding increases with:
- Taking blood thinning medications such as corticosteroids and anticoagulants
- Longer use
- Older age
- Having poor health
- Drinking alcohol
Some people will have a warning of stomach bleeding in the form of burning stomach pain, black stools, or vomiting. If you experience any of these symptoms, call your doctor.
It's also possible to sustain liver damage by taking NSAIDS like Meloxibell.
Warning signs of liver damage include nausea, vomiting, fatigue, appetite loss, itching, jaundice (yellowing of the skin or eyes), and dark urine.
The medication can also result in fluid retention and swelling, which may contribute to heart failure.
Meloxibell is associated with an increased risk of heart attack, stroke, and high blood pressure. Long-term use may increase these risks.
To ensure your safety when taking this medicine, tell your doctor if you have any of the following conditions:
- A history of heart attack, stroke, or blood clot