Get Help for Polydrug or Prescription Drug Abuse
Many people with substance use disorders struggle with multiple substances over the course of their lives. Meloxan is a prescription painkiller, and although it is an NSAID and cannot cause a high, some people may misuse or abuse the substance anyway due to a misunderstanding of what it is or in an effort to alleviate pain. In large doses, Meloxan can be very dangerous, especially to the gastrointestinal system. It is important to get help from a rehabilitation program as soon as possible to overcome addiction and substance abuse, especially polydrug abuse or issues with co-occurring disorders.
Meloxan is a long acting nonsteroidal antiinflammatory drug (NSAID) available by prescription only and used in therapy of chronic arthritis. Meloxan has been linked to rare instances of acute, clinically apparent liver injury.
Forms and strengths
- Form: oral tablet
- Strengths: 7.5 mg, 15 mg
- Form: oral tablet
- Strengths: 7.5 mg, 15 mg
Brand: Qmiiz ODT
- Form: orally disintegrating tablet
- Strengths: 7.5 mg, 15 mg
Renal Toxicity and Hyperkalemia
Long-term administration of NSAIDs, including Meloxan, has resulted in renal papillary necrosis, renal insufficiency, acute renal failure, and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, dehydration, hypovolemia, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors or ARBs, and the elderly. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.
The renal effects of Meloxan may hasten the progression of renal dysfunction in patients with preexisting renal disease. Because some Meloxan metabolites are excreted by the k >see Drug Interactions (7) ].
No information is available from controlled clinical studies regarding the use of Meloxan in patients with advanced renal disease. Avo >see Clinical Pharmacology (12.3) ].
Increases in serum potassium concentration, including hyperkalemia, have been reported with use of NSAIDs, even in some patients without renal impairment. In patients with normal renal function, these effects have been attributed to a hyporeninemic-hypoaldosteronism state.
Meloxan 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β- acetyldigoxin administration for 7 days at clinical doses. In vitro testing found no protein binding drug interaction between digoxin and Meloxan.
How Supplied/Storage and Handling
Meloxan Tablets USP, 7.5 mg are yellow, round-shaped, flat beveled edge, uncoated tablets debossed with 'ZC' and '25' on one side and plain on other side and are supplied as follows:
NDC 68382-050-16 in bottles of 90 tablets
NDC 68382-050-01 in bottles of 100 tablets
NDC 68382-050-05 in bottles of 500 tablets
NDC 68382-050-40 in bottles of 5000 tablets
NDC 68382-050-77 in unit-dose blister cartons of 100 (10 x 10) unit-dose tablets
Meloxan Tablets USP, 15 mg are yellow, round-shaped, flat beveled edge, uncoated tablet debossed with 'ZC' and '26' on one side and plain on other side and are supplied as follows:
NDC 68382-051-16 in bottles of 90 tablets
NDC 68382-051-01 in bottles of 100 tablets
NDC 68382-051-05 in bottles of 500 tablets
NDC 68382-051-40 in bottles of 5000 tablets
NDC 68382-051-77 in unit-dose blister cartons of 100 (10 x 10) unit-dose tablets
Store at 20° to 25° C (68° to 77° F) . Keep Meloxan tablets in a dry place.
Dispense tablets in a tight container.
Keep this and all medications out of the reach of children.
How to use Meloxan
Read the Medication Guide provided by your pharmacist before you start taking Meloxan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually once daily. Drink a full glass of water (8 ounces/240 milliliters) with it unless your doctor tells you otherwise. Do not lie down for at least 10 minutes after taking this drug.
If you are taking the liquid form of this medication, shake the bottle gently before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
If you are taking the disintegrating tablet, do not remove the tablet from the packaging until you are ready to take it. With dry hands, peel back the foil to carefully remove the tablet. Do not push the tablet through the foil because doing so can damage it. Place the tablet on your tongue right away and allow it to dissolve. After the tablet has melted, it can be swallowed with or without liquid.
If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. The dosage is based on your medical condition and response to treatment. The lowest effective dosage should always be used, and only for the prescribed length of time. Do not take more of this medication than prescribed because higher doses increase the chance of stomach ulcers/bleeding.
Meloxan may come in different forms (such as tablet, capsule, liquid, disintegrating tablet). Do not switch between different forms without consulting your doctor.
It may take up to two weeks before you get the full benefit of this drug. Use this medication regularly to get the most benefit from it. Remember to use it at the same time each day.
Tell your doctor if your condition worsens.
- Individuals who are allergic to NSAIDs may experience shortness of breath when given an NSAID. People with asthma also are at a higher risk for experiencing serious allergic reaction to NSAIDs. Individuals with a serious allergy to one NSAID are likely to experience a similar reaction to a different NSAID.
- New onset or worsening of high blood pressure (hypertension) may occur. Blood pressure should be monitored closely during treatment.
- Meloxan may cause fluid retention and swelling (edema). It should be used cautiously in people with heart failure.
- Meloxan may reduce kidney function. Therefore, it should not be used in people with severe kidney failure. It should be used cautiously in the elderly, people with heart failure, liver dysfunction, and those taking diuretics, ACE-inhibitors, or angiotensin II antagonists.
- Serious skin reactions such as exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis (TEN) may occur without warning.
- NSAIDs (except low dose aspirin) may increase the risk of potentially fatal heart attacks, stroke, and related conditions in people with or without heart disease or risk factors for heart disease. The increased risk of heart attack or stroke may occur as early as the first week of use and the risk may increase with longer use and is higher in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.
- Central nervous system effects including drowsiness, dizziness, and blurred vision may occur in patients who are taking an NSAIDs.