Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Heart attack. Symptoms can include:
- chest pain or discomfort
- trouble breathing
- cold sweat
- pain or discomfort in one or both arms, your back, shoulders, neck, jaw, or area above your belly button
- numbness or weakness of your face, arm, or leg on one s >Gastrointestinal side effects Abdominal pain, diarrhea, upset stomach, and nausea occur very often with this drug. Pain, vomiting, and diarrhea may occur more often in children than adults. Sometimes these side effects can cause more serious stomach problems.
If you or your child has these side effects and they bother you or don’t go away, talk to your doctor.
Melotec oral tablet can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.
Below is a list of medications that can interact with Melotec. This list does not contain all drugs that may interact with Melotec.
Before taking Melotec, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Melotec and Alcohol
Avoid drinking alcohol while taking Melotec, since it can increase the risk of stomach bleeding.
Which drugs or supplements interact with Melotec?
Melotec may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
Melotec may reduce the blood pressure-lowering effects of drugs given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
When Melotec is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
Melotec increases the negative effect of cyclosporine on kidney function and reduces the effect of furosemide (Lasix) and thiazide diuretics because of prostaglandin inhibition.
Individuals taking oral blood thinners, for example, warfarin (Coumadin), should avoid Melotec because Melotec also thins the blood, and excessive blood thinning may lead to bleeding.
Melotec should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. If aspirin is taken with Melotec there may be an increased risk for developing a gastrointestinal ulcer.
Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking Melotec or other NSAIDs.
Cholestyramine (Questran), colestipol (Colestid), and colesevelam (Welchol) may decrease the effectiveness of Melotec by preventing its absorption from the intestine.
Melotec oral suspension contains sorbitol. Combining sodium polystyrene sulfonate (Kayexalate) with sorbitol may cause fatal intestinal necrosis. Therefore, Melotec oral solution should not be combined with Kayexalate.
Rated Melotec for Osteoarthritis Report
Began taking 7.5 mg/day, but no help with symptoms/pain. Rx written to take 1 or 2 per day, so I began taking 2 per day. After about 2 weeks of taking the 2 per day dosage with no issues, the past 3 days I began having moderate and constant heartburn, feeling nauseous, a "knot" feeling in my stomach, and increased belching. I stopped taking the Mobic when the symptoms began and began a bland diet. No relief yet. Waiting for PCP recommendation about symptoms. Glad it helps some people, but this is not a good choice for me.
Melotec may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- sore throat
Osteoarthritis And Rheumatoid Arthritis
Carefully consider the potential benefits and risks of Melotec tablets, USP and other treatment options before deciding to use Melotec tablets, USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).
After observing the response to initial therapy with Melotec tablets, USP the dose should be adjusted to suit an individual patient's needs.
For the relief of the signs and symptoms of osteoarthritis the recommended starting and maintenance oral dose of Melotec is 7.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 15 mg once daily. For the relief of the signs and symptoms of rheumatoid arthritis, the recommended starting and maintenance oral dose of Melotec is 7.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 15 mg once daily.
The maximum recommended daily oral dose of Melotec is 15 mg.
Melotec may be taken without regard to timing of meals.
Warnings for other groups
For pregnant women: Using Melotec during your third trimester of pregnancy increases the risk of negative effects to your pregnancy. You should not take Melotec after 29 weeks of pregnancy. If you’re pregnant, talk to your doctor. Melotec should be used during pregnancy only if the potential benefit justifies the potential risk.
You should also talk to your doctor if you’re trying to get pregnant. Melotec can cause a reversible delay in ovulation. If you’re having a hard time getting pregnant or are getting tested for infertility, don’t take Melotec.
For women who are breastfeeding: It isn’t known if Melotec passes into breast milk. If it does, it could cause side effects in your child if you breastfeed and take Melotec. You and your doctor may decide whether you’ll take Melotec or breastfeed.
For seniors: If you’re age 65 years or older, you may have a higher risk of side effects from Melotec.
For children: For the treatment of JIA, this drug has been found to be safe and effective for use in children 2 years and older. It should not be used in children younger than 2 years.
For the treatment of other conditions, this drug has not been found to be safe and effective for children of any age. It should not be used in people younger than 18 years.
- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of us e. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS and Clinical Trials).
- Melotec is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
Carefully consider the potential benefits and risks of Melotec tablets and other treatment options before deciding to use Melotec tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).
Melotec tablet is indicated for relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis.
Diuretics (water pills)
Taking certain diuretics with Melotec can decrease the effect of these drugs. Examples of these diuretics include:
General Dosing Instructions
After observing the response to initial therapy with Melotec tablets, adjust the dose to suit an individual patient's needs.
In adults, the maximum recommended daily oral dose of Melotec tablets are 15 mg regardless of formulation. In patients with hemodialysis, a maximum daily dosage of 7.5 mg is recommended .
Melotec tablets may be taken without regard to timing of meals.
Rated Melotec for Moderate Pain Report
I took Melotec for RC tendonitis and it was worthless. After ten days I went back to Ibuprofen which seemed to work much better.
How to use Melotec
Read the Medication Guide provided by your pharmacist before you start taking Melotec and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually once daily. Drink a full glass of water (8 ounces/240 milliliters) with it unless your doctor tells you otherwise. Do not lie down for at least 10 minutes after taking this drug.
If you are taking the liquid form of this medication, shake the bottle gently before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
If you are taking the disintegrating tablet, do not remove the tablet from the packaging until you are ready to take it. With dry hands, peel back the foil to carefully remove the tablet. Do not push the tablet through the foil because doing so can damage it. Place the tablet on your tongue right away and allow it to dissolve. After the tablet has melted, it can be swallowed with or without liquid.
If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. The dosage is based on your medical condition and response to treatment. The lowest effective dosage should always be used, and only for the prescribed length of time. Do not take more of this medication than prescribed because higher doses increase the chance of stomach ulcers/bleeding.
Melotec may come in different forms (such as tablet, capsule, liquid, disintegrating tablet). Do not switch between different forms without consulting your doctor.
It may take up to two weeks before you get the full benefit of this drug. Use this medication regularly to get the most benefit from it. Remember to use it at the same time each day.
Tell your doctor if your condition worsens.
Melotec for Dogs and Cats
Melotec can be prescribed for for dogs and cats to manage their pain and inflammation.
In addition to arthritis pain, Melotec may be prescribed to dogs for pain from surgery, dental procedures, cancer, or injuries.
Because of the increased risk of side effects in cats, Melotec has limited use in cats and is generally only prescribed as a single dose.
Side effects can include loss of appetite, vomiting, diarrhea, bleeding, and stomach ulcers.
Melotec is a long acting nonsteroidal antiinflammatory drug (NSAID) available by prescription only and used in therapy of chronic arthritis. Melotec has been linked to rare instances of acute, clinically apparent liver injury.
Prospective studies show that up to 7% of patients taking Melotec experience at least transient serum aminotransferase elevations. These may resolve even with drug continuation. Aminotransferase elevations >3 fold elevated occur in 1% of patients. Clinically apparent liver injury with jaundice from Melotec is rare and only individual case reports have been published. The latency to onset in reported cases was short (1-5 weeks) and both cholestatic and hepatocellular patterns of enzyme elevations were described. Immunoallergic features are usually not prominent and autoantibodies are rare, although a single case report of autoimmune hepatitis apparently triggered by Melotec therapy has been published. Recovery is typically rapid once Melotec is stopped. Melotec is rarely mentioned as an etiologic agent in large case series on drug induced liver injury and acute liver failure.