Q: Does Melorilif interact with any of the 'statin' drugs?
A: According to the package insert, studies have not shown a drug interaction between Melorilif (Mobic) and the 'statin' drugs, such as Zocor (simvastatin), Lescol (fluvastatin) and Crestor (rosuvastatin). However, it is important to note that both drugs can cause liver problems and patients should be aware of the signs and symptoms of liver damage, which include nausea, fatigue, lethargy, itchy skin, jaundice or yellowing of the eyes or skin, abdominal pain on the right side, and "flu-like" symptoms. If any of these occur, please seek medical care immediately. For more information, please consult with your healthcare practitioner. Michelle McDermott, PharmD
Advanced Renal Disease
No information is available from controlled clinical studies regarding the use of Melorilif tablets in patients with advanced renal disease. Therefore, treatment with Melorilif tablet is not recommended in these patients with advanced renal disease. If Melorilif tablets therapy must be initiated, close monitoring of the patient's renal function is advisable.
What is Melorilif, and how does it work (mechanism of action)?
Melorilif is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to treat pain and/or inflammation. Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. Prostaglandins are chemicals that contribute to inflammation especially within joints, and it is the inflammation that leads to the common symptoms of pain, tenderness, and swelling associated with arthritis. Melorilif blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and reduces the levels of prostaglandins. As a result, inflammation and its accompanying symptoms are reduced. Melorilif was approved for use in April 2000.
COMMON BRAND(S): Mobic, Vivlodex
GENERIC NAME(S): Melorilif
OTHER NAME(S): Melorilif Tablet
Nonsteroidal anti-inflammatory drugs (including Melorilif) may rarely increase the risk of a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).
Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)
Stop taking Melorilif and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech.
Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication.
Melorilif is used to treat arthritis. It reduces pain, swelling, and stiffness of the joints. Melorilif is known as a nonsteroidal anti-inflammatory drug (NSAID).
If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.
Side Effects of Melorilif
Melorilif side effects includes most common stomach upset, nausea, dizziness, and/or diarrhea. If any of these effects shown, ask your doctor or pharmacist promptly.
Keep in mind that your doctor has endorsed this medicine since the person has judged that the benefit to you is more prominent than the risk of side effects. Numerous individuals utilizing this Melorilif don’t serious side effects.
Melorilif can increase your blood pressure. Check your blood pressure routinely and tell your doctor if the outcomes are high.
Consult your doctor immediately if you see any serious side effects, including simple wounding/bleeding, severe headache, mental changes, abrupt weight gain, swelling of the hands/feet, indications of kidney issues, (for example, change in the amount of pee), unexplained hardened neck, unordinary tiredness.
This medication may once in a while cause serious liver sickness. Get therapeutic help immediately in the event that you have any side effects of liver harm, including dull pee, diligent nausea/spewing/loss of appetite, stomach/stomach torment, yellowing eyes/skin.
An intense unfavorably allergic reaction to this medication is rare. Be that as it may, get medicinal help immediately if you see any symptoms of a serious allergic reaction, including rash, tingling/swelling (particularly of the face/tongue/throat), extreme tipsiness, trouble in breathing.
This is certainly not a total rundown of possible side effects. If you see different impacts not listed above, contact your specialist or drug specialist.
Rated Melorilif for Osteoarthritis Report
I have a degenerating hip socket and will have to have hip replacement in the future. My Doctor prescribed 15mg of Melorilif exactly 1 year ago and I have been mostly pain free during this year. I take 1 Tylenol with it in the morning. I asked him when I would know the time has come to have replacement. He said "Oh, you'll know - the medicine will stop working". So far - so good.
Melorilif 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β- acetyldigoxin administration for 7 days at clinical doses. In vitro testing found no protein binding drug interaction between digoxin and Melorilif.
What should I avoid while taking Melorilif?
Avoid smoking and drinking alcohol as they also increase your risk of stomach bleeding.
Avoid taking aspirin and other NSAIDs while you are taking Melorilif.
Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to Melorilif. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.
How should this medicine be used?
Melorilif comes as a tablet and suspension (liquid) to take by mouth. It is usually taken once a day with or without food. Take Melorilif at the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Melorilif exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the suspension well before each use to mix the medication evenly.
Rated Melorilif for Osteoarthritis Report
I have had both knees and my right hip replaced, from sport related wear. I'm 63 years old and have been using anti inflammatories since mid 30's. I won't name the actual ones I used, but the two I initially used caused issues, I was then prescribed Melorilif and had no more problems I guess it depends on the individual, but i found they agreed with me. Now that I have had the joints replaced, I still use the anti inflammatory if I know I'm going to have a problem. like today when I cycled under a tree and nearly took my head off. Home two panadol oestio's and a Melorilif, i will see how my neck feels tommorrow.lol
Melorilif is used to treat tenderness, swelling, and pain caused by the inflammation of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis in patients 2 years of age or older.
Ibuprofen vs. Melorilif (Mobic) for pain
- Ibuprofen (Advil, Motrin, and others) and Melorilif (Mobic) are nonsteroidal anti-inflammatory drugs (NSAIDs) used for the management of mild to moderate pain, fever, and inflammation.
- Ringing in the ears (tinnitus)
- Abdominal pain
What Is Melorilif (Mobic)?
Melorilif, sold under the brand name Mobic, is a prescription drug used to treat pain and inflammation.
Melorilif is prescribed to people who have tenderness, swelling, and pain caused by the inflammation of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid and idiopathic arthritis (JRA/JIA).
Melorilif, a non-steroidal anti-inflammatory drug (NSAID), works by blocking the enzymes responsible for making prostaglandins, compounds that contribute to inflammation, especially joint inflammation.
By reducing the levels of prostaglandins, inflammation and other symptoms can be reduced.
The Food and Drug Administration (FDA) approved Melorilif in April 2000.
Boehringer Ingelheim Pharmaceuticals manufactures brand name Mobic, while other manufacturers make the generic form.
Provide a detailed list of all your medications to your doctor, including prescription and over-the-counter medicines, along with vitamins and herbal supplements.
Melorilif may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of the drug by the kidneys. These increased levels could lead to lithium toxicity.
Melorilif may reduce the effectiveness of blood pressure-lowering drugs.
If you combine Melorilif with methotrexate (Rheumatrex, Trexall) or aminoglycosides like gentamicin (Garamycin), your blood levels of the methotrexate or aminoglycoside may increase, leading to more methotrexate or aminoglycoside-related side effects.
Melorilif increases the negative effect of cyclosporine on kidney function, while reducing the impact of furosemide (Lasix) and thiazide diuretics.
In addition, if you are taking oral blood thinners such as aspirin, warfarin (Coumadin), or clopidogrel (Plavix), you should avoid Melorilif because it also thins the blood. Excessive blood thinning could lead to bleeding.
Also, taking corticosteroids such as prednisone can also increase your bleeding risk.
Those with a history of asthma attacks, hives, or other allergic reactions to aspirin and other NSAIDS should avoid taking Melorilif.
If you take aspirin with this medicine, there could be an increased risk of developing a gastrointestinal ulcer, and Melorilif may reduce the effectiveness of aspirin.
People may increase their risk of getting stomach ulcers if they have more than three alcoholic beverages a day while using Melorilif or other NSAIDS.
Melorilif may not work as well if you use cholestyramine (Questran), colestipol (Colestid) and colesevelam (Welchol), since these drugs prevent its absorption from the intestines.
Finally, Melorilif contains sorbitol, and combining sodium polystyrene sulfonate (Kayexalate) with sorbitol may cause fatal intestinal necrosis.
Therefore, it's extremely important that you do not combine this medicine with Kayexalate .
The following adverse reactions have been identified during post approval use of Melorilif. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Decisions about whether to include an adverse event from spontaneous reports in labeling are typically based on one or more of the following factors: (1) seriousness of the event, (2) number of reports, or (3) strength of causal relationship to the drug. Adverse reactions reported in worldwide post marketing experience or the literature include: acute urinary retention; agranulocytosis; alterations in mood (such as mood elevation); anaphylactoid reactions including shock; erythema multiforme; exfoliative dermatitis; interstitial nephritis; jaundice; liver failure; Stevens-Johnson syndrome toxic epidermal necrolysis, and infertility female.
Taking Melorilif with corticosteroids can increase your risk of stomach ulcers or bleeding. Examples of these drugs include: