Melorem tablets

Melorem

  • Active Ingredient: Meloxicam
  • 15 mg, 7.5 mg
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What is Melorem?

The active ingredient of Melorem brand is meloxicam. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID). Meloxicam works by reducing hormones that cause inflammation and pain in the body.

Used for

Melorem is used to treat diseases such as: Fibromyalgia, Inflammatory Conditions, Juvenile Rheumatoid Arthritis, Osteoarthritis, Rheumatoid Arthritis, Tendonitis.

Side Effect

Possible side effects of Melorem include: greatly decreased frequency of urination or amount of urine; vomiting of blood or material that looks like coffee grounds; severe stomach pain; increased blood pressure; dry mouth.

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FDA warnings

  • This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
  • Heart risk warning: This drug may increase your risk of developing a blood clot, heart attack, or stroke, which can be fatal. Your risk may be higher if you’re taking it long term, at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure. You shouldn’t take Melorem for pain before, during, or after coronary artery bypass graft surgery. This can increase your risk for a heart attack or stroke.
  • Stomach problems warning: This medication may increase your risk of developing stomach and intestinal problems. These include bleeding, ulcers, and holes in your stomach or intestines, which can be fatal. These effects can occur any time while you’re taking this drug. They may happen without any signs or symptoms. Adults aged 65 years and older are at higher risk of these stomach or intestinal problems.

Juvenile Rheumato > For the treatment of juvenile rheumatoid arthritis, the recommended oral dose of Melorem tablets is 7.5 mg once daily in children who weigh ≥60 kg. There was no additional benefit demonstrated by increasing the dose above 7.5 mg in clinical trials.

Melorem tablets should not be used in children who weigh .

Melorem is a prescription drug. It comes in three forms: an oral tablet, an orally disintegrating tablet, and an oral capsule.

Melorem oral tablet is available as the brand-name drug Mobic. Melorem orally disintegrating tablet is available as the brand-name drug Qmiiz ODT.

Melorem oral tablet is also available as a generic drug. The orally disintegrating tablet is not. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Rated Melorem for Moderate Pain Report

Started taking Melorem 15mg daily about two weeks ago. One week into taking it, the pain was totally gone--I have arthritis in my lower back and brusitis in my hip--all on the left side. But. I have a history of moderate to severe depression and this makes me depressed more than usual and feel not myself. I also feel sick like having the stomach flu. I like this medicine because the pain is gone and other meds like ibuprofen, Tylenol, and aleve don't touch the pain. Yet, I am afraid I am going to have a relapse of major depression. I don't know what to do.

Q: Does Melorem have any side effects? Can it be taken with morphine, Percocet, Plavix, and Crestor? How does it work ?

A: Melorem (Mobic) is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis. Melorem is also used to relieve the pain, tenderness,swelling, and stiffness caused by juvenile rheumatoid arthritis in children two years of age and older. Melorem is in a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain, fever, and inflammation. According to multiple studies conducted, in thousands of patients taking Mobic, the most commonly encountered side effects involved the gastrointestinal system (abdominal pain, diarrhea, nausea, and upset stomach), headache, and flu-like symptoms (sore throat, cough, runny nose). More serious and rare side effects can occur, including fever, rash, hives, itching, swelling, or difficulty breathing or swallowing. If you experience any of the more serious side effects associated with Melorem, the physician should be contacted immediately. According to the prescribing information for Melorem, there are no documented drug interactions with morphine, Percocet (oxycodone/acetaminophen), or Crestor (rosuvastatin). However, Melorem should be used with caution in patients who are also taking Plavix (clopidogrel), as it has been shown in studies to cause gastrointestinal bleeding in some patients. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Crystal Riley, PharmD

By Sherry Karabin | Medically Reviewed by Ruthan White, PharmD

Latest Update: 2014-08-14 Copyright © 2014 Everyday Health Media, LLC

Melorem is not a substitute for low dose aspirin for cardiovascular protection. ACE Inhibitors , Angiotensin Receptor Blockers , or Beta - Blockers Clinical Impact :

NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol). In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Intervention :

During concomitant use of Melorem and ACE inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. During concomitant use of Melorem and ACE inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function, monitor for signs of worsening renal function . When these drugs are administered concomitantly, patients should be adequately hydrated. Assess renal function at the beginning of the concomitant treatment and periodically thereafter. Diuretics

Clinical Impact :

Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis. However, studies with furosemide agents and Melorem have not demonstrated a reduction in natriuretic effect. Furosemide single and multiple dose pharmacodynamics and pharmacokinetics are not affected by multiple doses of Melorem. Intervention :

During concomitant use of Melorem with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects . Lithium Clinical Impact :

NSA >see Clinical Pharmacology ( 12 . 3 )]. Intervention :

During concomitant use of Melorem and lithium, monitor patients for signs of lithium toxicity. Methotrexate Clinical Impact : Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction). Intervention : During concomitant use of Melorem and methotrexate, monitor patients for methotrexate toxicity. Cyclosporine

Clinical Impact : Concomitant use of Melorem and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention : During concomitant use of Melorem and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates

Clinical Impact : Concomitant use of Melorem with other NSA >see Warnings and Precautions ( 5 . 2 )]. Intervention : The concomitant use of Melorem with other NSAIDs or salicylates is not recommended. Pemetrexed

Clinical Impact : Concomitant use of Melorem and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information). Intervention : During concomitant use of Melorem and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity. Patients taking Melorem should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration. In patients with creatinine clearance below 45 mL/min, the concomitant administration of Melorem with pemetrexed is not recommended.

Melorem for Dogs and Cats

Melorem can be prescribed for for dogs and cats to manage their pain and inflammation.

In addition to arthritis pain, Melorem may be prescribed to dogs for pain from surgery, dental procedures, cancer, or injuries.

Because of the increased risk of side effects in cats, Melorem has limited use in cats and is generally only prescribed as a single dose.

Side effects can include loss of appetite, vomiting, diarrhea, bleeding, and stomach ulcers.

Precautions

Before taking Melorem, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), liver disease, stomach/intestine/esophagus problems (such as bleeding, ulcers, recurring heartburn), heart disease (such as history of heart attack), high blood pressure, stroke, blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps).

Kidney problems can sometimes occur with the use of NSAID medications, including Melorem. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).

This medication may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medication, may increase your risk for stomach bleeding. Limit alcohol and smoking. Consult your doctor or pharmacist for more information.

The disintegrating tablet form of Melorem may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to limit/avoid aspartame (or phenylalanine) in your diet, ask your doctor or pharmacist about using this medication safely.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially stomach bleeding and kidney problems.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk and are unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

COMMON BRAND(S): Mobic, Vivlodex

GENERIC NAME(S): Melorem

OTHER NAME(S): Melorem Tablet

Nonsteroidal anti-inflammatory drugs (including Melorem) may rarely increase the risk of a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).

Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)

Stop taking Melorem and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech.

Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication.

Melorem is used to treat arthritis. It reduces pain, swelling, and stiffness of the joints. Melorem is known as a nonsteroidal anti-inflammatory drug (NSAID).

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.


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