Melonex tablets

Melonex

  • Active Ingredient: Meloxicam
  • 15 mg, 7.5 mg
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What is Melonex?

The active ingredient of Melonex brand is meloxicam. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID). Meloxicam works by reducing hormones that cause inflammation and pain in the body.

Used for

Melonex is used to treat diseases such as: Fibromyalgia, Inflammatory Conditions, Juvenile Rheumatoid Arthritis, Osteoarthritis, Rheumatoid Arthritis, Tendonitis.

Side Effect

Possible side effects of Melonex include: scaly skin; trouble breathing; red, swollen skin; unusual bleeding or bruising; increased blood pressure.

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Melonex side effects

Get emergency medical help if you have signs of an allergic reaction to Melonex: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using Melonex and call your doctor at once if you have:

the first sign of any skin rash, no matter how mild;

shortness of breath (even with mild exertion);

swelling or rapid weight gain;

signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

liver problems - nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

kidney problems - little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

low red blood cells (anemia) - pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Melonex side effects may include:

upset stomach, nausea, vomiting, heartburn;

diarrhea, constipation, gas;

cold symptoms, flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Rated Melonex for Osteoarthritis Report

Meloxicom, ( Mobic), 15mg was prescribed for a fracture in my (L2) spine. At first I felt so weak almost like l could barely walk and felt heavy. But the pain was alleviated. It made me sleep all day. I first thought it was a muscle relaxer. After a couple days of taking it I felt chest pains, then a severe head ache on the right side of my head. I almost called 911. I was afraid to go to sleep. I eventually ended by the second week after committing the coffee like specks., hip pain, arm pain. Thought I was afraid I was going to have a stroke or heart attack. This could be just me I'm 48 yrs old and very tiny. Hopefully you have a better experience.

Melonex Overdose

It's important to take this and other medication as prescribed. If you feel you have taken too much get emergency help immediately.

Signs of overdose may include asthma-like symptoms, nausea, vomiting, gastritis, and upper abdominal pain or burning sensation.

Melonex is not a substitute for low dose aspirin for cardiovascular protection. ACE Inhibitors , Angiotensin Receptor Blockers , or Beta - Blockers Clinical Impact :

NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol). In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Intervention :

During concomitant use of Melonex and ACE inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. During concomitant use of Melonex and ACE inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function, monitor for signs of worsening renal function . When these drugs are administered concomitantly, patients should be adequately hydrated. Assess renal function at the beginning of the concomitant treatment and periodically thereafter. Diuretics

Clinical Impact :

Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis. However, studies with furosemide agents and Melonex have not demonstrated a reduction in natriuretic effect. Furosemide single and multiple dose pharmacodynamics and pharmacokinetics are not affected by multiple doses of Melonex. Intervention :

During concomitant use of Melonex with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects . Lithium Clinical Impact :

NSA >see Clinical Pharmacology ( 12 . 3 )]. Intervention :

During concomitant use of Melonex and lithium, monitor patients for signs of lithium toxicity. Methotrexate Clinical Impact : Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction). Intervention : During concomitant use of Melonex and methotrexate, monitor patients for methotrexate toxicity. Cyclosporine

Clinical Impact : Concomitant use of Melonex and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention : During concomitant use of Melonex and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates

Clinical Impact : Concomitant use of Melonex with other NSA >see Warnings and Precautions ( 5 . 2 )]. Intervention : The concomitant use of Melonex with other NSAIDs or salicylates is not recommended. Pemetrexed

Clinical Impact : Concomitant use of Melonex and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information). Intervention : During concomitant use of Melonex and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity. Patients taking Melonex should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration. In patients with creatinine clearance below 45 mL/min, the concomitant administration of Melonex with pemetrexed is not recommended.

Introduction

Melonex is a long acting nonsteroidal antiinflammatory drug (NSAID) available by prescription only and used in therapy of chronic arthritis. Melonex has been linked to rare instances of acute, clinically apparent liver injury.

Precautions

Before taking Melonex, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), liver disease, stomach/intestine/esophagus problems (such as bleeding, ulcers, recurring heartburn), heart disease (such as history of heart attack), high blood pressure, stroke, blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps).

Kidney problems can sometimes occur with the use of NSAID medications, including Melonex. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).

This medication may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medication, may increase your risk for stomach bleeding. Limit alcohol and smoking. Consult your doctor or pharmacist for more information.

The disintegrating tablet form of Melonex may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to limit/avoid aspartame (or phenylalanine) in your diet, ask your doctor or pharmacist about using this medication safely.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially stomach bleeding and kidney problems.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk and are unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Osteoarthritis and Rheumato > The use of Melonex for the treatment of the signs and symptoms of osteoarthritis of the knee and hip was evaluated in a 12-week, double-blind, controlled trial. Melonex (3.75 mg, 7.5 mg, and 15 mg daily) was compared to placebo. The four primary endpoints were investigator’s global assessment, patient global assessment, patient pain assessment, and total WOMAC score (a self-administered questionnaire addressing pain, function, and stiffness). Patients on Melonex 7.5 mg daily and Melonex 15 mg daily showed significant improvement in each of these endpoints compared with placebo.

The use of Melonex for the management of signs and symptoms of osteoarthritis was evaluated in six double-blind, active-controlled trials outside the U.S. ranging from 4 weeks’ to 6 months’ duration. In these trials, the efficacy of Melonex, in doses of 7.5 mg/day and 15 mg/day, was comparable to piroxicam 20 mg/day and diclofenac SR 100 mg/day and consistent with the efficacy seen in the U.S. trial.

The use of Melonex for the treatment of the signs and symptoms of rheumatoid arthritis was evaluated in a 12-week, double-blind, controlled multinational trial. Melonex (7.5 mg, 15 mg, and 22.5 mg daily) was compared to placebo. The primary endpoint in this study was the ACR20 response rate, a composite measure of clinical, laboratory, and functional measures of RA response. Patients receiving Melonex 7.5 mg and 15 mg daily showed significant improvement in the primary endpoint compared with placebo. No incremental benefit was observed with the 22.5 mg dose compared to the 15 mg dose.


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