Meloksam tablets

Meloksam

  • Active Ingredient: Meloxicam
  • 15 mg, 7.5 mg
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What is Meloksam?

The active ingredient of Meloksam brand is meloxicam. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID). Meloxicam works by reducing hormones that cause inflammation and pain in the body.

Used for

Meloksam is used to treat diseases such as: Fibromyalgia, Inflammatory Conditions, Juvenile Rheumatoid Arthritis, Osteoarthritis, Rheumatoid Arthritis, Tendonitis.

Side Effect

Possible side effects of Meloksam include: weight gain (rapid); swelling or puffiness of the face; blurred vision; bloody or black, tarry stools; heartburn; bloating.

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Juvenile Rheumato > For the treatment of juvenile rheumatoid arthritis, the recommended oral dose of Meloksam tablets is 7.5 mg once daily in children who weigh ≥60 kg. There was no additional benefit demonstrated by increasing the dose above 7.5 mg in clinical trials.

Meloksam tablets should not be used in children who weigh .

Meloksam and Alcohol

Avoid drinking alcohol while taking Meloksam, since it can increase the risk of stomach bleeding.

Before taking Meloksam,

  • tell your doctor and pharmacist if you are allergic to Meloksam, sorbitol, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn),any other medications, or any of the ingredients in Meloksam tablets and suspension. Ask your doctor or pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril , enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), and quinapril (Accupril, in Accuretic, in Quinaretic); angiotensin receptor blockers such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); cholestyramine (Prevalite); cyclosporine (Gengraf, Neoral, Sandimmune); diuretics ('water pills'); lithium (Lithobid); methotrexate (Otrexup, Rasuvo, Trexall); pemetrexed (Alimta); and sodium polystyrene sulfonate products (Kayexalate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had asthma, especially if you have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); heart failure; swelling of the hands, feet, ankles, or lower legs; or kidney or liver disease.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breastfeeding. If you become pregnant while taking Meloksam, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Meloksam.
  • if you have fructose intolerance (an inherited condition in which the body lacks the protein needed to break down fructose ), you should know that the oral suspension is sweetened with sorbitol. Tell your doctor if you have fructose intolerance.

Rated Meloksam for Osteoarthritis Report

Took Meloksam for just over a month, gave me severe depression, stopped taking it and the depression has subsided. Will be informing my doctors when I see them next.

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately. Do not take any more Meloksam until you speak to your doctor:

  • fever
  • blisters
  • rash
  • skin blisters or peeling
  • hives
  • itching
  • swelling of the eyes, face, tongue, lips, or throat
  • difficulty breathing or swallowing
  • hoarseness
  • pale skin
  • fast heartbeat
  • shortness of breath or difficulty breathing
  • unexplained weight gain,
  • swelling in the abdomen, ankles, feet, or legs
  • nausea
  • excessive tiredness
  • lack of energy
  • yellowing of the skin or eyes
  • pain in the right upper part of the stomach
  • flu-like symptoms
  • cloudy, discolored, or bloody urine
  • back pain
  • difficult or painful urination

Meloksam may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Rated Meloksam for Osteoarthritis Report

So I have had herniated disks on and off for 15 years..my new doc gave me cortisone injections in the spaces between the vertibrae. and perscribed me Meloksam.so I take it and get diarrhea, and don't know for sure if it's because of the med. take it the second day. get even worse diarrhea and it make me dizzy as hell. I'm not going for a 3rd day.

Is it safe to take ibuprofen 24 hrs after taking Meloksam?

Updated 29 Apr 2014 • 1 answer

How should this medicine be used?

Meloksam comes as a tablet and suspension (liquid) to take by mouth. It is usually taken once a day with or without food. Take Meloksam at the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Meloksam exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before each use to mix the medication evenly.

Warnings for people with certain health conditions

For people with heart or blood vessel diseases: This medication increases your risk of blood clots, which can cause a heart attack or stroke. It may also cause fluid retention, which is common with heart failure.

For people with high blood pressure: This medication may make your blood pressure worse, which can increase your risk of having a heart attack or stroke.

For people with stomach ulcer or bleeding: Meloksam can make these conditions worse. If you have a history of these conditions, you have a higher chance of having them again if you take this medicine.

For people with liver damage: Meloksam can cause liver disease and changes in your liver function. It may make your liver damage worse.

For people with kidney disease: If you take Meloksam for a long time, it may decrease your kidney function, making your kidney disease worse. Stopping this drug could reverse kidney damage caused by the drug.

For people with asthma: Meloksam can cause bronchial spasm and difficulty breathing, especially if your asthma gets worse if you take aspirin.

What are the side effects of Meloksam?

WARNING

  • Individuals who are allergic to NSAIDs may experience shortness of breath when given an NSAID. People with asthma also are at a higher risk for experiencing serious allergic reaction to NSAIDs. Individuals with a serious allergy to one NSAID are likely to experience a similar reaction to a different NSAID.
  • New onset or worsening of high blood pressure (hypertension) may occur. Blood pressure should be monitored closely during treatment.
  • Meloksam may cause fluid retention and swelling (edema). It should be used cautiously in people with heart failure.
  • Meloksam may reduce kidney function. Therefore, it should not be used in people with severe kidney failure. It should be used cautiously in the elderly, people with heart failure, liver dysfunction, and those taking diuretics, ACE-inhibitors, or angiotensin II antagonists.
  • Serious skin reactions such as exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis (TEN) may occur without warning.
  • NSAIDs (except low dose aspirin) may increase the risk of potentially fatal heart attacks, stroke, and related conditions in people with or without heart disease or risk factors for heart disease. The increased risk of heart attack or stroke may occur as early as the first week of use and the risk may increase with longer use and is higher in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.
  • Central nervous system effects including drowsiness, dizziness, and blurred vision may occur in patients who are taking an NSAIDs.

Common side effects with NSAIDs are related to the gastrointestinal tract (GI) and include:

To prevent these common side effects, it is recommended that most NSAIDs be taken with food or milk. NSAIDs may cause ulcers in the stomach and/or small intestine. A few NSAIDs are designed to be less damaging to the stomach and small intestine, therefore; they may be taken with or without food. Meloksam is an example of one of these NSAIDs, but nevertheless, it should be taken cautiously without food. NSAIDs have been associated with an increased risk of blood clots that can cause strokes and heart attacks. NSAIDs also may interfere with the function of the kidneys or injure the kidneys.

Other important side effects of Meloksam are:

Rated Meloksam for Osteoarthritis Report

My doc put me on Meloksam for osteoarthritis a little over a month ago. I am taking a single dose of 7.5 mg daily. It has helped tremendously with my joint pain. But, about 2 weeks ago I started developing severe headaches on a daily basis. Five days ago I wound up in the emergency room because I was having trouble breathing, stomach cramps, nausea, vomiting, diarrhea, loss of appetite and taste, blurred vision, dizziness, numbness and tingling in my hands, arms and chest, rapid heartbeat, chest pain, mind fog, and trouble concentrating. I thought I was going to have a heart attack or stroke and really felt like I was going to die! I have had 2 more of these episodes since taking this drug. No more! This drug is very dangerous and should be banned! I wish I had done more research before taking this drug.

How it works

Meloksam belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

It isn’t known how this medication works to decrease pain. It may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

Meloksam can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking Meloksam. This list does not include all possible side effects.

For more information on the possible side effects of Meloksam, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.

When a Meloksam is administered with aspirin (1000 mg TID) to healthy volunteers, it tended to increase the AUC (10%) and Cmax (24%) of Meloksam. The clinical significance of this interaction is not known; however, as with other NSAIDs concomitant administration of Meloksam and aspirin is not generally recommended because of the potential for increased adverse effects.

Concomitant administration of low-dose aspirin with Meloksam tablets may result in an increased rate of GI ulceration or other complications, compared to use of Meloksam tablets alone. Meloksam tablet is not a substitute for aspirin for cardiovascular prophylaxis.

1 MedDRA high level term (preferred terms): dyspeptic signs and symptoms (dyspepsia, dyspepsia aggravated, eructation, gastrointestinal irritation), upper respiratory tract infections-pathogen unspecified (laryngitis NOS, pharyngitis NOS, sinusitis NOS), joint related signs and symptoms (arthralgia, arthralgia aggravated, joint crepitation, joint effusion, joint swelling)

2 MedDRA preferred term: nausea, abdominal pain NOS, influenza-like illness, headaches NOS, and rash NOS

No . of Patients 469 481 477 Gastrointestinal Disorders 14.1 18.9 16.8 Abdominal pain NOS 2 0.6 2.9 2.3 Dyspeptic signs and symptoms 1 3.8 5.8 4.0 Nausea 2 2.6 3.3 3.8 General Disorders and Administration Site Conditions Influenza-like illness 2 2.1 2.9 2.3 Infection and Infestations Upper respiratory tract infections-pathogen >1 4.1 7.0 6.5 Musculoskeletal and Connective Tissue Disorders Joint related signs and symptoms 1 1.9 1.5 2.3 Nervous System Disorders Headaches NOS 2 6.4 6.4 5.5 Skin and Subcutaneous Tissue Disorders Rash NOS 2 1.7 1.0 2.1

The adverse events that occurred with Meloksam in ≥2% of patients treated short-term (4 to 6 weeks) and long-term (6 months) in active-controlled osteoarthritis trials are presented in Table 2

Anaphylactoid Reactions

As with other NSAIDS, anaphylactoid reactions have occurred in patients without known prior exposure to Meloksam. Meloksam tablets should not be given to patients with the aspirin triad. This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs (see CONTRAINDICATIONS and PRECAUTIONS, Pre-existing Asthma). Emergency help should be sought in cases where an anaphylactoid reaction occurs.

Rated Meloksam for Moderate Pain Report

Started taking Meloksam 15mg daily about two weeks ago. One week into taking it, the pain was totally gone--I have arthritis in my lower back and brusitis in my hip--all on the left side. But. I have a history of moderate to severe depression and this makes me depressed more than usual and feel not myself. I also feel sick like having the stomach flu. I like this medicine because the pain is gone and other meds like ibuprofen, Tylenol, and aleve don't touch the pain. Yet, I am afraid I am going to have a relapse of major depression. I don't know what to do.

Renal Impairment

No dose adjustment is necessary in patients with mild to moderate renal impairment. Patients with severe renal impairment have not been studied. The use of Meloksam in subjects with severe renal impairment is not recommended. In patients on hemodialysis, Meloksam should not exceed 7.5 mg per day. Meloksam is not dialyzable .

Blood pressure warning

This medication may increase or worsen your blood pressure. This can increase your risk of heart attack or stroke. Your doctor may check your blood pressure while you’re taking Meloksam. Some medicines for high blood pressure may not work as well as they should when you’re taking Meloksam.

Meloksam 7.5mg and Meloksam 15mg tablets help combat inflammation, swelling, a stiffness of the joints, and pain. Meloksam is quite effective for the alleviation and reduction of the symptoms of osteoarthritis. However, there is the possibility of side effects that can occur with the use of Meloksam which can result in swelling of the feet, hands, ankles, throat, tongue, and many other parts of the body.

Meloksam is generally taken in tablet form. Meloksam 7.5 mg is typically the common dosage, but Meloksam 15 mg tablets are also readily available. Meloksam tablets are yellow in color, round or oval in design, and are uncoated. You must orally consume Meloksam, and the tablets can be crushed or cut. You should take the recommended dosage with a full glass of water while in a sitting, or upright position. It is best that you first take a sip of water before consumption, as it will help you to better swallow the tablets. If you can arrange it, the ideal time to take Meloksam is at night at least ten minutes before you go to sleep. If your stomach becomes upset during use, try taking it with food and water, or milk. Schedule your dosages each day at the very same time. You should always seek the advice of your doctor and be well informed of the side effects of this medication. Never consider taking this medication more often than what is prescribed by your doctor.


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