Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately. Do not take any more Melokan until you speak to your doctor:
- skin blisters or peeling
- swelling of the eyes, face, tongue, lips, or throat
- difficulty breathing or swallowing
- pale skin
- fast heartbeat
- shortness of breath or difficulty breathing
- unexplained weight gain,
- swelling in the abdomen, ankles, feet, or legs
- excessive tiredness
- lack of energy
- yellowing of the skin or eyes
- pain in the right upper part of the stomach
- flu-like symptoms
- cloudy, discolored, or bloody urine
- back pain
- difficult or painful urination
Melokan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Osteoarthritis And Rheumatoid Arthritis
Carefully consider the potential benefits and risks of Melokan tablets, USP and other treatment options before deciding to use Melokan tablets, USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).
After observing the response to initial therapy with Melokan tablets, USP the dose should be adjusted to suit an individual patient's needs.
For the relief of the signs and symptoms of osteoarthritis the recommended starting and maintenance oral dose of Melokan is 7.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 15 mg once daily. For the relief of the signs and symptoms of rheumatoid arthritis, the recommended starting and maintenance oral dose of Melokan is 7.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 15 mg once daily.
The maximum recommended daily oral dose of Melokan is 15 mg.
Melokan may be taken without regard to timing of meals.
Fluid retention and edema have been observed in some patients taking NSAIDs. Melokan tablets should be used with caution in patients with fluid retention, hypertension, or heart failure.
Melokan for Dogs and Cats
Melokan can be prescribed for for dogs and cats to manage their pain and inflammation.
In addition to arthritis pain, Melokan may be prescribed to dogs for pain from surgery, dental procedures, cancer, or injuries.
Because of the increased risk of side effects in cats, Melokan has limited use in cats and is generally only prescribed as a single dose.
Side effects can include loss of appetite, vomiting, diarrhea, bleeding, and stomach ulcers.
No dose adjustment is necessary in patients with mild to moderate renal impairment. Patients with severe renal impairment have not been studied. The use of Melokan in subjects with severe renal impairment is not recommended. In patients on hemodialysis, Melokan should not exceed 7.5 mg per day. Melokan is not dialyzable .