Mecam tablets

Mecam

  • Active Ingredient: Meloxicam
  • 15 mg, 7.5 mg
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What is Mecam?

The active ingredient of Mecam brand is meloxicam. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID). Meloxicam works by reducing hormones that cause inflammation and pain in the body.

Used for

Mecam is used to treat diseases such as: Fibromyalgia, Inflammatory Conditions, Juvenile Rheumatoid Arthritis, Osteoarthritis, Rheumatoid Arthritis, Tendonitis.

Side Effect

Possible side effects of Mecam include: sudden loss of coordination; difficulty with swallowing; skin blisters; cloudy urine; stomach bloating, burning, cramping, tenderness, or pain; watery or bloody diarrhea; sores, welting, or blisters; convulsions (seizures).

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This is a popular medication in the treatment of osteoarthritis, rheumatoid arthritis, and other chronic conditions that cause pain due to swelling in the joints. The Food and Drug Administration (FDA) approved Mecam for prescription use in the US in 2000.

Carcinogenesis, Mutagenesis, Impairment of Fertility

There was no increase in tumor incidence in long-term carcinogenicity studies in rats (104 weeks) and mice (99 weeks) administered Mecam at oral doses up to 0.8 mg/kg/day in rats and up to 8.0 mg/kg/day in mice (up to 0.5-and 2.6-times, respectively, the maximum recommended human dose of 15 mg/day Mecam based on body surface area comparison).

Mecam was not mutagenic in an Ames assay, or clastogenic in a chromosome aberration assay with human lymphocytes and an in vivo micronucleus test in mouse bone marrow.

Impairment of Fertility

Mecam did not impair male and female fertility in rats at oral doses up to 9 mg/kg/day in males and 5 mg/kg/day in females (up to 5.8- and 3.2-times greater, respectively, than the MRHD based on BSA comparison).

Postmarketing Experience

The following adverse reactions have been identified during post approval use of Mecam. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Decisions about whether to include an adverse event from spontaneous reports in labeling are typically based on one or more of the following factors: (1) seriousness of the event, (2) number of reports, or (3) strength of causal relationship to the drug. Adverse reactions reported in worldwide post marketing experience or the literature include: acute urinary retention; agranulocytosis; alterations in mood (such as mood elevation); anaphylactoid reactions including shock; erythema multiforme; exfoliative dermatitis; interstitial nephritis; jaundice; liver failure; Stevens-Johnson syndrome toxic epidermal necrolysis, and infertility female.

Q: I have been taking Mecam daily for around 3 months. I also take Lyrica, topiramate, Cymbalta, pantoprazole, Provigil, and a high blood pressure medicine. All of the medicines I have been taking long term except for the Mecam, and I have had no problems. About a month ago, I started having a lot of heart burn which has been pretty bad. I have had to start taking a lot of Tums and cut back on eating a lot of things which didn't help. I finally just stop taking Mecam and my stomach has settled down. Do you think this medicine is the cause? I like the medicine because it did take the pain away, but not at the cost of the heart burn. I haven't call my doctor yet, but is there another medicine that would work as well? I have tried Celebrex, but that did not work for me.

A: Mobic (Mecam) belongs to a class of medication known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). Mecam is used to reduce pain and inflammation caused by arthritis. Heartburn is one of the most common side effects associated with Mecam. Unfortunately, heartburn is a side effect of all medications within this class. Your doctor may consider trying a different NSAID in hopes that you will not be as sensitive to the side effects of the new medication as you are to Mecam. Some of the other medications in this class are Aleve (naproxen), Arthrotec (diclofenac/misoprostol), Daypro (oxaprozin), Feldene (piroxicam), Lodine (etodolac), Motrin (ibuprofen), and Relafen (nabumetone). This is not a complete list of the side effects associated with Mecam. Megan Uehara, PharmD

General Dosing Instructions

After observing the response to initial therapy with Mecam tablets, adjust the dose to suit an individual patient's needs.

In adults, the maximum recommended daily oral dose of Mecam tablets are 15 mg regardless of formulation. In patients with hemodialysis, a maximum daily dosage of 7.5 mg is recommended .

Mecam tablets may be taken without regard to timing of meals.

Rated Mecam for Osteoarthritis Report

Began taking 7.5 mg/day, but no help with symptoms/pain. Rx written to take 1 or 2 per day, so I began taking 2 per day. After about 2 weeks of taking the 2 per day dosage with no issues, the past 3 days I began having moderate and constant heartburn, feeling nauseous, a "knot" feeling in my stomach, and increased belching. I stopped taking the Mobic when the symptoms began and began a bland diet. No relief yet. Waiting for PCP recommendation about symptoms. Glad it helps some people, but this is not a good choice for me.

Mecam Description

Mecam is a nonstero >N -(5-methyl-2-thiazolyl)-2 H -1,2-benzothiazine-3-carboxam >14 H 13 N 3 O 4 S 2 and it has the following structural formula.

Allergy warning

Mecam can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take Mecam if you have asthma, runny nose, and nasal polyps (aspirin triad). Don’t take it if you’ve had itching, trouble breathing, or an allergic reaction to aspirin or other NSAIDs.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Rated Mecam for Moderate Pain Report

Started taking Mecam 15mg daily about two weeks ago. One week into taking it, the pain was totally gone--I have arthritis in my lower back and brusitis in my hip--all on the left side. But. I have a history of moderate to severe depression and this makes me depressed more than usual and feel not myself. I also feel sick like having the stomach flu. I like this medicine because the pain is gone and other meds like ibuprofen, Tylenol, and aleve don't touch the pain. Yet, I am afraid I am going to have a relapse of major depression. I don't know what to do.

Anaphylactoid Reactions

As with other NSAIDS, anaphylactoid reactions have occurred in patients without known prior exposure to Mecam. Mecam tablets should not be given to patients with the aspirin triad. This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs (see CONTRAINDICATIONS and PRECAUTIONS, Pre-existing Asthma). Emergency help should be sought in cases where an anaphylactoid reaction occurs.

COMMON BRAND(S): Mobic, Vivlodex

GENERIC NAME(S): Mecam

OTHER NAME(S): Mecam Tablet

Nonsteroidal anti-inflammatory drugs (including Mecam) may rarely increase the risk of a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).

Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)

Stop taking Mecam and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech.

Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication.

Mecam is used to treat arthritis. It reduces pain, swelling, and stiffness of the joints. Mecam is known as a nonsteroidal anti-inflammatory drug (NSAID).

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

Generic Name: Mecam (mel OKS i kam)Brand Names: Mobic, Vivlodex, Mecam Comfort Pac

Medically reviewed by Sophia Entringer, PharmD Last updated on Jan 4, 2019.


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