Provide a detailed list of all your medications to your doctor, including prescription and over-the-counter medicines, along with vitamins and herbal supplements.
Ilacox may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of the drug by the kidneys. These increased levels could lead to lithium toxicity.
Ilacox may reduce the effectiveness of blood pressure-lowering drugs.
If you combine Ilacox with methotrexate (Rheumatrex, Trexall) or aminoglycosides like gentamicin (Garamycin), your blood levels of the methotrexate or aminoglycoside may increase, leading to more methotrexate or aminoglycoside-related side effects.
Ilacox increases the negative effect of cyclosporine on kidney function, while reducing the impact of furosemide (Lasix) and thiazide diuretics.
In addition, if you are taking oral blood thinners such as aspirin, warfarin (Coumadin), or clopidogrel (Plavix), you should avoid Ilacox because it also thins the blood. Excessive blood thinning could lead to bleeding.
Also, taking corticosteroids such as prednisone can also increase your bleeding risk.
Those with a history of asthma attacks, hives, or other allergic reactions to aspirin and other NSAIDS should avoid taking Ilacox.
If you take aspirin with this medicine, there could be an increased risk of developing a gastrointestinal ulcer, and Ilacox may reduce the effectiveness of aspirin.
People may increase their risk of getting stomach ulcers if they have more than three alcoholic beverages a day while using Ilacox or other NSAIDS.
Ilacox may not work as well if you use cholestyramine (Questran), colestipol (Colestid) and colesevelam (Welchol), since these drugs prevent its absorption from the intestines.
Finally, Ilacox contains sorbitol, and combining sodium polystyrene sulfonate (Kayexalate) with sorbitol may cause fatal intestinal necrosis.
Therefore, it's extremely important that you do not combine this medicine with Kayexalate .
Ilacox can cause a severe allergic reaction. Symptoms may include:
- trouble breathing
- swelling of your throat or tongue
Don’t take Ilacox if you have asthma, runny nose, and nasal polyps (aspirin triad). Don’t take it if you’ve had itching, trouble breathing, or an allergic reaction to aspirin or other NSAIDs.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Concomitant administration of 200 mg cimetidine QID did not alter the single-dose pharmacokinetics of 30 mg Ilacox.
In a study conducted in healthy subjects, mean pre-dose lithium concentration and AUC were increased by 21% in subjects receiving lithium doses ranging from 804 to 1072 mg BID with Ilacox 15 mg QD as compared to subjects receiving lithium alone. These effects have been attributed to inhibition of renal prostaglandin synthesis by Ilacox tablets patients on lithium treatment should be closely monitored for signs of lithium toxicity when Ilacox tablets is introduced, adjusted, or withdrawn.
For the relief of the signs and symptoms of osteoarthritis the recommended starting and maintenance oral dose of Ilacox tablets is 7.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 15 mg once daily.
It's important to take this and other medication as prescribed. If you feel you have taken too much get emergency help immediately.
Signs of overdose may include asthma-like symptoms, nausea, vomiting, gastritis, and upper abdominal pain or burning sensation.