Hipokinon syrup

Hipokinon

  • Active Ingredient: Trihexyphenidyl
  • 2 mg
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What is Hipokinon?

The active ingredient of Hipokinon brand is trihexyphenidyl. Trihexyphenidyl alters unusual nerve impulses and relaxes stiff muscles.

Used for

Hipokinon is used to treat diseases such as: Cerebral Spasticity, Extrapyramidal Reaction, Parkinson's Disease.

Side Effect

Possible side effects of Hipokinon include: bloating; false beliefs that cannot be changed by facts; constipation; restlessness; trouble sleeping; hyperventilation; mild nausea; change in vision.

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Trihexyphen >

Use caution when driving, operating machinery, or performing other hazardous activities. Hipokinon may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Hipokinon.

Avoid becoming overheated. Hipokinon may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise. Try to keep as cool as possible and watch for signs of heat stroke such as decreased sweating, nausea, and dizziness.

Before taking this medication, tell your doctor if you are taking any of the following medicines:

  • a tricyclic antidepressant (used to treat depression, pain, or obsessive-compulsive disorder) such as amitriptyline (Elavil, Endep), doxepin (Sinequan), clomipramine (Anafranil), amoxapine (Asendin), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), or protriptyline (Vivactil);
  • a phenothiazine (used to treat mania, schizophrenia, other psychiatric conditions, and nausea and vomiting) such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine (Mellaril), promazine (Sparine), trifluoperazine (Stelazine), and others;
  • thiothixene (Navane) or chlorprothixene (Taractan);
  • an antihistamine such as diphenhydramine (Benadryl, others), chlorpheniramine (Chlor-Trimeton, others), triprolidine (Actifed, others), brompheniramine (Dimetapp, others), clemastine (Tavist), and others (antihistamines are often found in prescription and over-the-counter cold, allergy, and sleep medicines);
  • quinidine (Quinora, Quinaglute, Quinidex, Cardioquin);
  • amantadine (Symmetrel);
  • digoxin (Lanoxin, Lanoxicaps); or
  • haloperidol (Haldol).

You may not be able to take Hipokinon or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with Hipokinon. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Drug-Induced Parkinsonism

The size and frequency of the ARTANE (Hipokinon) dose needed to control extrapyramidal reactions to commonly employed tranquilizers, notably the phenothiazines, thioxanthenes, and butyrophenones, must be determined empirically. The total daily dosage usually ranges between 5 and 15 mg although, in some cases, these reactions have been satisfactorily controlled with as little as 1 mg daily. It may be advisable to commence therapy with a single 1 mg dose. If the extrapyramidal manifestations are not controlled in a few hours, the subsequent doses may be progressively increased until satisfactory control is achieved. Satisfactory control may sometimes be more rapidly achieved by temporarily reducing the dosage of the tranquilizer when instituting ARTANE (Hipokinon) therapy and then adjusting the dosage of both drugs until the desired ataractic effect is retained without onset of extrapyramidal reactions.

It is sometimes possible to maintain the patient on a reduced ARTANE (Hipokinon) dosage after the reactions have remained under control for several days. Instances have been reported in which these reactions have remained in remission for long periods after ARTANE (Hipokinon) therapy was discontinued.

Neuroleptic Malignant Syndrome

A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with dose reduction or discontinuation of Hipokinon. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias).

The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (eg, pneumonia, systemic infection, etc.) and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system (CNS) pathology.

How should I use this medication?

For treatment of Parkinson's disease, the recommended dose of Hipokinon starts with 1 mg the first day and then increases by 2 mg daily at intervals of 3 to 5 days until symptoms are controlled. The usual daily dose ranges from 6 mg to 10 mg daily depending on needs (taken in divided doses at mealtimes).

The dose needed for medication-induced symptoms varies widely according to the particular medication and dose that are causing the symptoms.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What should I avo >

Use caution when driving, operating machinery, or performing other hazardous activities. Hipokinon may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Hipokinon.

Avoid becoming overheated. Hipokinon may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise. Try to keep as cool as possible and watch for signs of heat stroke such as decreased sweating, nausea, and dizziness.

Baclofen

Baclofen is somewhat less effective than Hipokinon in most children, but can be helpful in diminishing pain caused by dystonia. It can provide additional benefit when used in combination with Hipokinon. A typical starting dose is 5 mg at bedtime. The dose should be increased slowly until desired benefit or side effects occur. The usual maintenance dose is 10 to 60 mg/day in three divided doses, but some older children obtain maximum benefit at doses as high as 180 mg/day. The most common side effect is sedation. Sudden cessation can precipitate seizures or psychosis and should be avoided.

In patients with good benefit from oral baclofen, but who cannot tolerate the effective dose because of side effects, intrathecal baclofen may be an option. Few data are available on the use of intrathecal baclofen in primary dystonia, and the use of this therapy in primary dystonia is controversial. 105, 106

About trihexyphen >

Hipokinon is an antimuscarinic medicine. It is prescribed for people who have unwanted movement disorders as a side-effect of taking certain other medicines, such as some antipsychotic medicines. These movement disorders are often referred to as 'extrapyramidal side-effects' and include things like uncontrolled face and body movements, tremor, and restlessness.

Why is this medication prescribed?

Hipokinon is used along with other medications to treat the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and to control extrapyramidal symptoms (tremor, slurred speech) caused by certain medications. Hipokinon is in a class of medications called antimuscarinics. It works by relaxing muscles and nerve impulses that control the function of muscles.

How should I take Hipokinon (Artane, Trihexane)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Your doctor will tell you whether you should take Hipokinon before or after a meal.

Take the medicine with food if it upsets your stomach.

If Hipokinon causes your mouth to feel dry, you may need to take it before meals.

You may also use mints, chewing gum, or water if you have a very dry mouth or you feel very thirsty.

The pressure inside your eyes will need to be checked while you are taking Hipokinon.

You should not stop using Hipokinon suddenly. Stopping suddenly may make your condition worse.

Store at room temperature away from moisture, heat, and light. Do not freeze.

General

Patients with cardiac, liver, or kidney disorders, or with hypertension, should be closely monitored.

Since ARTANE (Hipokinon) has atropine-like properties, patients on long-term treatment should be carefully monitored for untoward reactions.

Since ARTANE (Hipokinon) has parasympatholytic activity, it should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts, and in elderly males with possible prostatic hypertrophy. Incipient glaucoma may be precipitated by parasympatholytic drugs such as ARTANE (Hipokinon) .

Tardive dyskinesia may appear in some patients on long-term therapy with antipsychotic drugs or may occur after therapy with these drugs has been discontinued. Antiparkinsonism agents do not alleviate the symptoms of tardive dyskinesia, and in some instances may aggravate them. However, parkinsonism and tardive dyskinesia often coexist in patients receiving chronic neuroleptic treatment, and anticholinergic therapy with ARTANE (Hipokinon) may relieve some of these parkinsonism symptoms. ARTANE (Hipokinon) is not recommended for use in patients with tardive dyskinesia unless they have concomitant Parkinson's disease.

Patients with arteriosclerosis or with a history of idiosyncrasy to other drugs may exhibit reactions of mental confusion, agitation, disturbed behavior, or nausea and vomiting. Such patients should be allowed to develop a tolerance through the initial administration of a small dose and gradual increase in dose until an effective level is reached. If a severe reaction should occur, administration of the drug should be discontinued for a few days and then resumed at a lower dosage. Psychiatric disturbances can result from indiscriminate use (leading to overdosage) to sustain continued euphoria. (See Drug Abuse And Dependence)

Abrupt withdrawal of treatment for parkinsonism may result in acute exacerbation of parkinsonism symptoms; therefore, abrupt withdrawal should be avoided (see DOSAGE AND ADMINISTRATION)

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Drowsiness/reduced alertness: Hipokinon may impair the mental or physical abilities required to perform hazardous tasks such as driving or operating machinery. Avoid these activities if the medication affects you in this way.

Hot conditions: Hipokinon may reduce the amount of perspiration produced. This can affect the body's ability to cool itself. Try to avoid overheating due to hot weather and heavy exercise.

Medical conditions: People with the following medical conditions should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed:

  • heart disease
  • kidney disease
  • liver disease
  • chronic obstructive pulmonary disease
  • high blood pressure
  • ulcerative colitis
  • gastroesophageal reflux disease (GERD)
  • trouble with stomach emptying
  • stomach infections
  • stomach ulcers
  • prostate problems

Pregnancy: The safety and effectiveness of using this medication have not been established for pregnant women. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if Hipokinon passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Seniors may be at a higher risk for side effects and may require lower doses.

DESCRIPTION

ARTANE (Hipokinon HCl) is a synthetic antispasmodic drug available in the following forms:

Tablets: Containing 2 mg and 5 mg ARTANE (Hipokinon HCl), each strength also containing as inactive ingredients: Corn Starch, Dibasic Calcium Phosphate, Magnesium Stearate and Pregelatinized Starch.

Elixir: Containing 2 mg/5 mL ARTANE (Hipokinon HCl) in a clear, colorless, lime-mint flavored preparation, also containing as inactive ingredients: Alcohol 5%, Citric Acid, Flavorings, Methylparaben, Propylparaben, Sodium Chloride and Sorbitol Solution.

Drug form and strengths

Generic: Hipokinon

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg

Trihexyphen >About Hipokinon
  • Before taking Hipokinon
  • How to take Hipokinon
  • Getting the most from your treatment
  • Can Hipokinon cause problems?
  • How to store Hipokinon
  • Important information about all medicines
  • Rated Hipokinon for Drug-induced Extrapyram >Report

    I was put on this very dangerous drug because I have cerebral palsy. I felt like I was losing my mind. I was in HELL!! I was hallucinating, and was so thirsty that I was drinking liquids all of the time, nothing would slake my thirst. I went to three different psychiatrists and was hospitalized three times. I finally was seen by a neurologist who told me to get off of this pill. Since that time, I am much better, but I have side side effects from it which will last me the rest of my life. I will never be able to hold a job because I was taking this medication for so long, that I am too old to work and too little work experience, even with my college degree. THIS DRUG RUINED MY ENTIRE LIFE AND PUT ME THROUGH LIVING HELL. DO NOT TAKE THIS VERY DANGEROUS DRUG, EVER.

    Dosage for parkinsonism

    Adult dosage (ages 18–59 years)

    • Typical starting dosage: 1 mg per day.
    • Dosage increases: Your doctor may increase your dosage by 2 mg every 3–5 days, until you’re taking 6–10 mg per day.
    • Note: If your parkinsonism was caused by a viral infection, you may need a dosage of 12–15 mg per day.

    Child dosage (ages 0–17 years)

    It has not been confirmed that Hipokinon is safe and effective for use in children younger than 18 years.

    Senior dosage (ages 65 years and older)

    If you’re older than 60 years, you may be more sensitive to the effects of Hipokinon. It has been shown to cause more confusion and memory loss in older people. Your doctor may start you on a low dosage and watch for side effects.

    What are the possible side effects of Hipokinon (Artane, Trihexane)?

    Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Call your doctor at once if you have:

    • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
    • hot and dry skin, or a lack of sweating even if you feel hot;
    • rapid or jerky repetitive involuntary movement;
    • severe constipation;
    • painful or difficult urination;
    • unusual thoughts or behavior;
    • confusion, memory problems; or
    • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

    Common side effects may include:

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    PATIENT INFORMATION

    ARTANE (Hipokinon) may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that ARTANE (Hipokinon) therapy does not adversely affect their ability to engage in such activities.

    Because of increased sedative effects, patients should be cautioned to avoid the use of alcohol or other CNS depressants while taking ARTANE (Hipokinon) .

    Since this medication may increase the susceptibility to heat stroke (gastrointestinal (GI) problems, fever, heat intolerance), use with caution during hot weather. (See WARNINGS.)

    Patients should be advised to report the occurrence of GI problems, fever, or heat intolerance promptly since paralytic ileus, hyperthermia, or heat stroke may occur.

    If GI upset occurs, ARTANE (Hipokinon) may be taken with food.

    Patients should have close monitoring of intraocular pressure. (See WARNINGS.)

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    Hipokinon can also be given to relieve muscle stiffness in people with Parkinson's disease, although other medicines are generally preferred.


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