Glocyp tablets


  • Active Ingredient: Cyproheptadine
  • 4 mg
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What is Glocyp?

The active ingredient of Glocyp brand is cyproheptadine. Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. C21H21N•HCl M.W. 350.89 Cyproheptadine hydrochloride, USP is available for oral administration in 4 mg tablets. Inactive ingredients include: lactose monohydrate, magnesium stearate, microcrystalline cellulose, and pregelatinized starch.

Used for

Glocyp is used to treat diseases such as: Allergic Reactions, Allergic Rhinitis, Anorexia, Anorexia Nervosa, Cluster Headaches, Cushing's Syndrome, Failure to Thrive, Migraine, Pruritus, Sexual Dysfunction, SSRI Induced, Urticaria.

Side Effect

Possible side effects of Glocyp include: ; ; ; ; ; ; ; .

How to Buy Glocyp syrup online?

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Glocyp Overdose

If you suspect an overdose, you should contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at (800) 222-1222.

Generic Name: Glocyp (SIP roe HEP ta deen)Brand Name: Periactin

Medically reviewed by on Sep 30, 2019 – Written by Cerner Multum

COMMON BRAND(S): Periactin


OTHER NAME(S): Glocyp Tablet

Glocyp is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. This medication also blocks another natural substance in your body (serotonin).

This medication should not be used in newborn or premature infants.

Indications and Usage for Glocyp

Perennial and seasonal allergic rhinitis

Allergic conjunctivitis due to inhalant allergens and foods.

Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.

Amelioration of allergic reactions to blood or plasma.

As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.

2.7.3 Interference of Glocyp and Quetiapine With Immunoassays for TCAs

Glocyp is an antihistamine that is used for treating various allergic symptoms. Wians et al. reported a case of a 14-year-old girl who, after ingesting approximately 120 mg of Glocyp tablets, tested positive for TCAs in serum by EMIT assay. In vitro studies indicated that a Glocyp concentration of 400 ng/mL may cause false-positive TCA results, although serum obtained from a volunteer who was given a 12-mg dose of Glocyp for 3 days showed no TCAs when tested by the same EMIT assay .

Case Report: A 5-year-old child was taken to the emergency room due to unusual behavior after awakening from a nap. On examination, it was observed that she was agitated and her toxicology screen was positive for TCAs. The family was advised to bring all household medications to the emergency room; these included Glocyp tablets, hydroxyzine syrup, carbinoxamine syrup, nitroglycerine tablets, and multivitamin tablets. Her aunt reported that the child was playing with some tablets on the floor, and later those pills were identified as Glocyp using gas chromatography/mass spectrometric analysis. When the child’s serum was further analyzed by a reference HPLC method, no peak was observed for nordoxepin, doxepin, desipramine, imipramine, nortriptyline, and amitriptyline, but a peak was observed with the same retention time as Glocyp standard, indicating that the false-positive serum TCA level detected by the EMIT assay was indeed due to interference of Glocyp metabolite .

Quetiapine, an atypical antipsychotic used for treating schizophrenia and acute episodes of bipolar disorders and also as an augmentor for treatment of depression, cross-reacts with the plasma TCA immunoassay and the false-positive response is dependent on quetiapine concentration. A 34-year-old man with a history of refractory-schizoaffective disorder and amphetamine dependence was admitted to the hospital for his depressive and psychotic symptoms. His only prescribed medication during admission was quetiapine 600 mg/day. On admission, his urine toxicology screen showed positive for TCA (at a level over the cutoff of 300 ng/mL) but negative for other illicit drugs, and the false-positive TCA was determined to be due to quetiapine interference with this homogeneous enzyme immunoassay for TCAs (Diagnostics Reagents) on the Hitachi 911 analyzer .

What is Glocyp (Periactin)?

Glocyp is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Glocyp is used to treat sneezing, runny nose, itching, red or watery eyes, and other symptoms of seasonal allergies (hay fever). Glocyp is also used to treat other conditions such as eczema or skin reactions to insect bites.

Glocyp is sometimes used to treat certain types of headaches, including migraines.

Glocyp may also be used for purposes not listed in this medication guide.

Nursing Mothers

It is known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from Glocyp, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother (see CONTRAINDICATIONS).

What is the most important information I should know about Glocyp (Periactin)?

You should not use Glocyp if you have narrow-angle glaucoma, a stomach ulcer or obstruction, an enlarged prostate, urination problems, or if you are having an asthma attack. You also should not use Glocyp if you are breast-feeding a baby, if you are elderly, or if you have a debilitating disease.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

You should not use antihistamine medication to make a child sleepy.

What other drugs will affect Glocyp (Periactin)?

Taking Glocyp with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with Glocyp, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.


Glocyp has an atropine-like action and, therefore, should be used with caution in patients with:

History of bronchial asthma

Increased intraocular pressure

home drugs a-z list Glocyp(Glocyp Hydrochloride) side effects drug center

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Glocyp (Glocyp hydrochloride) is an antihistamine used to treat sneezing, itching, watery eyes, runny nose, and other symptoms of allergies. Glocyp is available in generic form. Common side effects of Glocyp include:

  • drowsiness,
  • tired feeling,
  • sleep problems (insomnia),
  • dizziness,
  • spinning sensation,
  • blurred vision,
  • loss of coordination,
  • upset stomach,
  • nausea,
  • diarrhea,
  • constipation,
  • appetite changes,
  • weight gain,
  • restlessness or excitability (especially in children),
  • numbness or tingly feeling,
  • increased sweating or urination,
  • thickening of mucus in the nose/throat, or
  • dry mouth/throat/nose.

Tell your doctor if you have serious side effects of Glocyp including:

Adult dosing for Glocyp ranges from 4 mg to 20 mg per day. Pediatric dosing is usually calculated based on body weight. Glocyp may adversely interact with some medications including anticholinergic drugs, antispasmodic drugs, drugs for Parkinson's disease, MAO inhibitors, SSRI antidepressants, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotic pain relievers, psychiatric medicines, or any medication that may cause drowsiness, including cough-and-cold products. This medication should be used only when prescribed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication passes into breast milk. Due to the potential risk to the nursing infant, breastfeeding while using this drug is not recommended. Consult your doctor before breastfeeding.

Our Glocyp Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other uses for this medicine

Glocyp also is used for the treatment of Cushing's Syndrome (an abnormal condition that is caused by excess hormones ) and to treat certain types of headache such as migraine.Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

What Is Glocyp?

Glocyp is a prescription medication used to relieve allergy symptoms, itching, and to increase appetite.

Glocyp belongs to group of drugs known as first-generation antihistamines.

It works by blocking the release of histamine, a chemical in the body that causes allergic responses such as a runny nose, watery eyes, sneezing, and itching.

Glocyp was originally approved by the Food and Drug Administration (FDA) under the brand name Periactin in 1961 and was manufactured by Merck Pharmaceuticals.

Periactin is no longer on the market, and the only form currently available is generic Glocyp.

What are the possible s >

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Glocyp and call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • tremor, seizure (convulsions);
  • confusion, hallucinations;
  • little or no urination;
  • fast or pounding heartbeats;
  • easy bruising or bleeding;
  • ringing in your ears; or
  • pale or yellowed skin, dark colored urine, fever, weakness.

Common side effects may include:

  • drowsiness, dizziness;
  • dry mouth, nose, or throat;
  • constipation;
  • blurred vision; or
  • feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Glocyp may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dry mouth, nose, and throat
  • drowsiness
  • dizziness
  • nausea
  • chest congestion
  • headache
  • excitement (especially in children)
  • muscle weakness

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