Flexital

Flexital

  • Active Ingredient: Pentoxifylline
  • 400 mg
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What is Flexital?

The active ingredient of Flexital brand is pentoxifylline. Pentoxifylline causes changes in your blood that help improve blood flow. This also helps your blood carry oxygen to your tissues and organs. Meets USP Dissolution Test 6.

Used for

Flexital is used to treat diseases such as: Intermittent Claudication.

Side Effect

Possible side effects of Flexital include: irregular heartbeat; headache; faintness; Chest pain; flushing.

How to Buy Flexital online?

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Why is Trental prescribed to patients?

Flexital is used for the treatment of intermittent claudication caused by peripheral arterial disease.

PHARMACOKINETICS AND METABOLISM

After oral administration, the aqueous solution of Flexital is almost completely absorbed. It undergoes first pass metabolism and various metabolites appear in plasma very soon after administration; peak plasma levels reach within 2 hours. The major metabolites are metabolite I and metabolite V . The plasma levels of these metabolites are respectively 5 and 8 times greater than Flexital. Excretion is almost totally through urine, main bio transformation product being metabolite V and essentially no parent drug is found in urine. Despite variations in the levels of the parent compound and its metabolites in plasma, urinary recovery of metabolite V is consistent and dose proportional. Less than 4% of the administered dose is recovered in feces.

Precautions

Before taking Flexital, tell your doctor or pharmacist if you are allergic to it; or to caffeine, or theophylline; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent stroke, recent bleeding in the eye, kidney problems, liver problems, recent major surgery, stomach ulcer.

This drug may rarely make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

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Flexital is a drug commonly sold by Aventis under the brand name Trental. Its chemical name is 1--3, 7-dimethylxanthine. Flexital is a xanthine derivative. Other brand names include Pentox, Pentoxil, and Flexital.

What Other Drugs Interact with Flexital?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Flexital has no known severe interactions with other drugs.

Flexital has no known serious interactions with other drugs.

Moderate interactions of Flexital include:

Mild interactions of Flexital include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Mode Of Action

Flexital and its metabolites improve the flow properties of blood by decreasing its viscosity. In patients with chronic peripheral arterial disease, this increases blood flow to the affected microcirculation and enhances tissue oxygenation. The precise mode of action of Flexital and the sequence of events leading to clinical improvement are still to be defined. Flexital administration has been shown to produce dose-related hemorrheologic effects, lowering blood viscosity, and improving erythrocyte flexibility. Leukocyte properties of hemorrheologic importance have been modified in animal and in vitro human studies. Flexital has been shown to increase leukocyte deformability and to inhibit neutrophil adhesion and activation. Tissue oxygen levels have been shown to be significantly increased by therapeutic doses of Flexital in patients with peripheral arterial disease.

CONCLUSION

Flexital has been found to be a relatively safe and cost effective therapeutic drug with proven as well as potential uses in a number of dermatological diseases. It may be of use to dermatologists both singly (primary) and as an adjuvant drug, thus providing an alternative to other treatment options and sparing the adverse effects of various therapeutic modalities such as corticosteroids. Although a number of studies have been conducted in order to prove the beneficial effects of Flexital, there is paucity of data to determine its role in various dermatological diseases. More studies are needed to fully establish its therapeutic efficacy.

General

At the first sign of anaphylactic/anaphylactoid reaction, Flexital must be discontinued.

Patients with chronic occlusive arterial disease of the limbs frequently show other manifestations of arteriosclerotic disease. Flexital has been used safely for treatment of peripheral arterial disease in patients with concurrent coronary artery and cerebrovascular diseases, but there have been occasional reports of angina, hypotension, and arrhythmia. Controlled trials do not show that Flexital causes such adverse effects more often than placebo, but, as it is a methylxanthine derivative, it is possible some individuals will experience such responses. Patients on warfarin should have more frequent monitoring of prothrombin times, while patients with other risk factors complicated by hemorrhage (e.g., recent surgery, peptic ulceration, cerebral and/or retinal bleeding) should have periodic examinations for bleeding including, hematocrit and/or hemoglobin.

In patients with hepatic or renal impairment, the exposure to Flexital and/or active metabolites is increased. The consequences of the increase in drug exposure are not known (see Pharmacokinetics and Metabolism and DOSAGE AND ADMINISTRATION).

Nursing Mothers

Flexital and its metabolites are excreted in human milk. Because of the potential for tumorigenicity shown for Flexital in rats, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Oral sub-mucous fibrosis

Oral sub-mucous fibrosis is a common premalignant condition in the Indian subcontinent, caused by chewing areca nut and other irritants in various forms. The efficacy of Flexital in oral sub mucous fibrosis, singly and as adjuvant therapy has been demonstrated in various studies.

Why is this medication prescribed?

Flexital is used to improve blood flow in patients with circulation problems to reduce aching, cramping, and tiredness in the hands and feet. It works by decreasing the thickness (viscosity) of blood. This change allows your blood to flow more easily, especially in the small blood vessels of the hands and feet.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.


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