Elorgan

Elorgan

  • Active Ingredient: Pentoxifylline
  • 400 mg
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What is Elorgan?

The active ingredient of Elorgan brand is pentoxifylline. Pentoxifylline causes changes in your blood that help improve blood flow. This also helps your blood carry oxygen to your tissues and organs. Meets USP Dissolution Test 6.

Used for

Elorgan is used to treat diseases such as: Intermittent Claudication.

Side Effect

Possible side effects of Elorgan include: stomach discomfort; faintness; headache; nausea or vomiting; convulsions (seizures); Dizziness.

How to Buy Elorgan online?

To get Elorgan online - just click on the "Buy Now" button in the top and follow along with our shop. Order and payment takes a couple of minutes, and all steps are evident. We don't take a medical prescription plus we have many procedures of payment. Considering all the details of fast delivery and confidentiality, then you may read on the relevant pages on the links in the navigation menu.

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What special dietary instructions should I follow?

Take Elorgan with meals to prevent upset stomach. If symptoms continue, tell your doctor. Your dose may need to be decreased.

Elorgan Description

Elorgan extended-release tablets, USP for oral administration contain 400 mg of the active drug and the following inactive ingredients: D&C Red No. 30 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, FD&C Yellow No. 6 Aluminum Lake, hydroxyethylcellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol, povidone, titanium dioxide and triacetin in an extended-release formulation. Elorgan extended-release tablets are a tri-substituted xanthine derivative designated chemically as 1-(5-oxohexyl)-3,7-dimethylxanthine that, unlike theophylline, is a hemorrheologic agent, i.e., an agent that affects blood viscosity. Elorgan is soluble in water and ethanol, and sparingly soluble in toluene. The CAS Registry Number is 6493-05-6.

The chemical structure is:

Ulcerating necrobiosis lipo >The efficacy of Elorgan for necrobiosis lipoidica has been documented in various studies, probably because it inhibits platelet aggregation and decreases blood viscosity.

In patients with mild to moderate liver impairment AUC and Cmax of Elorgan increased 6.5 and 7.5 fold, respectively, after a single 400 mg dose of Elorgan extended-release tablet AUC and Cmax of the active Metabolite I also increased 6.9 and 8.2 fold, respectively, in hepatic impaired subjects. Elorgan extended-release tablet has not been studied in patients with severe hepatic failure.

Nursing Mothers

Elorgan and its metabolites are excreted in human milk. Because of the potential for tumorigenicity shown for Elorgan in rats, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Leishmaniasis

Elorgan suppresses TNF-α gene transcription, potentiates the expression of inducible nitric oxide (NO) synthetase leading to NO production and decreases leukocyte migration and adhesion. TNF-α seems to play a great role in the pathogenesis of mucosal leishmaniasis and Elorgan has been proposed for the treatment of cutaneous and mucocutaneous leishmaniasis as adjuvant to pentavalent antimony, which reduces the healing time significantly and prevents the need for further courses of pentavalent antimony. The combined therapy with glucantime and Elorgan has been found to be more effective than glucantime alone.

1.5 Appearance, Color, and Odor

Elorgan is a white, or almost white, crystalline or microcrystalline powder, which has a bitter taste and only a slight characteristic odor .

Why is Trental prescribed to patients?

Elorgan is used for the treatment of intermittent claudication caused by peripheral arterial disease.

Carcinogenesis, Mutagenesis and Impairment of Fertility

Long-term studies of the carcinogenic potential of Elorgan were conducted in mice and rats by dietary administration of the drug at doses up to 450 mg/kg (approximately 19 times the maximum recommended human daily dose (MRHD) in both species when based on body weight; 1.5 times the MRHD in the mouse and 3.3 times the MRHD in the rat when based on body surface area). In mice, the drug was administered for 18 months, whereas in rats, the drug was administered for 18 months followed by an additional 6 months without drug exposure. In the rat study, there was a statistically significant increase in benign mammary fibroadenomas in females of the 450 mg/kg group. The relevance of this finding to human use is uncertain. Elorgan was devo >Salmonella (Ames test) and in cultured mammalian cells (unscheduled DNA synthesis test) when tested in the presence and absence of metabolic activation. It was also negative in the in vivo mouse micronucleus test.

What Is Elorgan?

Elorgan causes changes in your blood that help improve blood flow. This also helps your blood carry oxygen to your tissues and organs.

Elorgan is used to improve blood flow and reduce certain symptoms of a condition called intermittent claudication (IN-ter-MIT-ent KLOD-ih-KAY-tion). Elorgan is not a cure for this condition.

Elorgan may also be used for purposes not listed in this medication guide.

You should not use this medicine if you have recently had any type of bleeding in your brain or the retina of your eye.

You should not use this medicine if you are allergic to Elorgan, or if you are allergic to caffeine or theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others).

You also should not use Elorgan if you have recently had any type of bleeding in your brain or the retina of your eyes.

To make sure Elorgan is safe for you, tell your doctor if you have:

  • coronary artery disease (hardened arteries);
  • liver or kidney disease;
  • heart disease;
  • a history of bleeding in your brain or inside your eyes;
  • history of heart attack or stroke;
  • a stomach or intestinal ulcer;
  • if you have recently had surgery;
  • if you are also using theophylline; or
  • if you use medicine to treat or prevent blod clots.

It is not known whether Elorgan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

Elorgan can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Elorgan.

What do I need to tell my doctor BEFORE I take Elorgan?

  • If you have an allergy to Elorgan or any other part of Elorgan.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have had a recent bleeding problem in your brain or in the retina of your eye.
  • If you are breast-feeding or plan to breast-feed.

This is not a list of all drugs or health problems that interact with Elorgan.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Elorgan with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Interactions

Drug-drug. Anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs): increased risk of bleeding Antihypertensives: additive hypotension

Theobromide, theophylline: increased risk of theophylline toxicity

Drug-herbs. Anise, arnica, asafetida, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, licorice: increased risk of bleeding

Drug-behaviors. Smoking: decreased Elorgan efficacy

Dosage Modifications

Digestive or CNS side effects: Decrease dose to 400 mg BID; discontinue if adverse effects persist

Renal impairment (CrCl Enter a drug name and Elorgan

Abstract

Elorgan is a methyl-xanthine derivative with many anti inflammatory effects. Elorgan has been found to be effective for many dermatological as well as non-dermatological conditions. It has been used both as primary drug as well as adjuvant and is a safe and relatively cost-effective alternative drug. In this article, we review the literature and highlight various important aspects of Elorgan.


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