CYP3A4 inducers can increase the rate of Tegretol metabolism. Drugs that have been shown, or that would be expected, to decrease plasma Carbagen levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline.
Pharmacologic class: Iminostilbene derivative
Therapeutic class: Anticonvulsant
Pregnancy risk category D
Very rare (less than 0.01%): Increase in prolactin (with or without symptoms such as gynecomastia or galactorrhea), impaired male fertility and/or abnormal spermatogenesis, abnormal thyroid function tests (e.g., decreased L-thyroxine and increased TSH)
Frequency not reported: Lower serum testosterone, lower free androgen indexes, increased cerebrospinal fluid thyrotropin-releasing hormone levels
Carbagen increases the rate of T4 and T3 metabolism and may lead to hypothyroidism in patients with hypothyroidism who are being treated with T4. Carbagen may also cause a 20% to 40% decrease in serum total and free T4 concentrations and a smaller decrease in serum total and free T3 concentrations in patients who have no thyroid disease.
COMMON BRAND(S): Tegretol
GENERIC NAME(S): Carbagen
Carbagen may rarely cause very serious (possibly fatal) skin reactions. Some people in certain ethnic groups (such as people of Asian/South Asian descent) are at greater risk. Your doctor may order a blood test to measure your risk before you start this medication. If the blood test shows you are at greater risk, your doctor should discuss the risks and benefits of Carbagen and other treatment choices with you. Such skin reactions have developed mostly within the first few months of treatment. Get medical help right away if you develop any of the following symptoms: skin rash/blisters/peeling, itching, or swelling. Ask your doctor or pharmacist for more details.
This drug has rarely caused very serious blood disorders (aplastic anemia, agranulocytosis). Your doctor will monitor your blood counts to minimize the chance of these side effects. Keep all medical and lab appointments. Get medical help right away if any of these rare but very serious side effects occur: signs of infection (such as sore throat that doesn't go away, fever, swollen lymph nodes), unusual weakness/tiredness, shortness of breath, or easy bleeding/bruising.
Carbagen is used to prevent and control seizures. This medication is known as an anticonvulsant or anti-epileptic drug. It is also used to relieve certain types of nerve pain (such as trigeminal neuralgia). This medication works by reducing the spread of seizure activity in the brain and restoring the normal balance of nerve activity.
Carbagen (CBZ), sold under the tradename Tegretol among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain.
What is Carbagen?
Carbagen is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and nerve pain, such as tregimenal neuralgia and diabetic neuropathy.
Carbagen is also used to treat bipolar disorder.
Carbagen may also be used for purposes not listed in this medication guide.
1. About Carbagen
Carbagen is a medicine used to treat epilepsy.
It can also be taken for nerve pain caused by diabetes (peripheral neuropathy) or if you have a painful condition of the face called trigeminal neuralgia.
Carbagen is occasionally used to treat bipolar disorder when other medicines haven't worked.
This medicine is only available on prescription. It comes as tablets, a liquid that you drink and suppositories (medicine that you push gently into your anus).
For the Consumer
Applies to Carbagen: oral capsule extended release, oral suspension, oral tablet, oral tablet chewable, oral tablet extended release
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Carbagen.