Diuretics (water pills)
Taking certain diuretics with Artrilom can decrease the effect of these drugs. Examples of these diuretics include:
Mechanism of Action
Artrilom has analgesic, anti-inflammatory, and antipyretic properties.
The mechanism of action of Artrilom, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Artrilom is a potent inhibitor of prostaglandin synthesis in vitro . Artrilom concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Artrilom is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Q: I have been taking Artrilom daily for around 3 months. I also take Lyrica, topiramate, Cymbalta, pantoprazole, Provigil, and a high blood pressure medicine. All of the medicines I have been taking long term except for the Artrilom, and I have had no problems. About a month ago, I started having a lot of heart burn which has been pretty bad. I have had to start taking a lot of Tums and cut back on eating a lot of things which didn't help. I finally just stop taking Artrilom and my stomach has settled down. Do you think this medicine is the cause? I like the medicine because it did take the pain away, but not at the cost of the heart burn. I haven't call my doctor yet, but is there another medicine that would work as well? I have tried Celebrex, but that did not work for me.
A: Mobic (Artrilom) belongs to a class of medication known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). Artrilom is used to reduce pain and inflammation caused by arthritis. Heartburn is one of the most common side effects associated with Artrilom. Unfortunately, heartburn is a side effect of all medications within this class. Your doctor may consider trying a different NSAID in hopes that you will not be as sensitive to the side effects of the new medication as you are to Artrilom. Some of the other medications in this class are Aleve (naproxen), Arthrotec (diclofenac/misoprostol), Daypro (oxaprozin), Feldene (piroxicam), Lodine (etodolac), Motrin (ibuprofen), and Relafen (nabumetone). This is not a complete list of the side effects associated with Artrilom. Megan Uehara, PharmD
Rated Artrilom for Rheumato >Report
I have been on Artrilom 15mg once daily for a week. I have already noticed a lot less pain. I am only 29 but could barely walk after getting out of bed in the morning. Now the pain is gone and I can walk down my back steps with out problems. Only side effect I have noticed is within a couple hours of taking I have diarrhea.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Artrilom only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 12.03.
Rheumato > For the relief of the signs and symptoms of rheumatoid arthritis, the recommended starting and maintenance oral dose of Artrilom tablets is 7.5 mg once daily. Some patients may receive additional benefit by increasing the dose to 15 mg once daily.
Rated Artrilom for Moderate Pain Report
I was prescribed this for psoriatic arthritis pain, and for about 2 weeks it seemed to be working great, but all of the sudden I started having trouble sleeping, couldn't fall back to sleep, and worse I was having bouts of depression that were so bad, I actually was having suicidal thoughts I couldn't control or explain. I became really agitated and having mood swings, causing fights over nothing with my spouse. It really messed me up. I have had some depression in the past, but not like this. I feel like if you're prone or have a history, it can make it come back or get so much worse. I flushed the pills today. It wasn't worth the joint pain relief I got.
How long do I wait after taking 400 mg ibuprofen to take 15 mg of Artrilom?
Updated 15 Feb 2017 • 2 answers FAQ by Drugs.com
Does anyone know how to wean off of Artrilom or can you just stop taking it like Ibuprofen & take?
Updated 26 Jul 2018 • 2 answers
Artrilom S >
Patients taking Artrilom may experience a wide array of side effects, including these less serious conditions:
- Heartburn, diarrhea
- Bloating, gas, constipation
- Upset stomach, nausea, vomiting
- Dizziness, headache
If you notice any signs of anaphylaxis (a severe allergic reaction), such as hives, difficulty breathing, swelling of your face, lips, tongue or throat, seek emergency assistance right away.
Quit taking Artrilom and call your doctor right away if you have any of the following problems:
- Chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance
NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
A study in 13 rheumatoid arthritis (RA) patients evaluated the effects of multiple doses of Artrilom on the pharmacokinetics of methotrexate taken once weekly. Artrilom did not have a significant effect on the pharmacokinetics of single doses of methotrexate. In vitro, methotrexate did not displace Artrilom from its human serum binding sites.
Side Effects of Artrilom
Artrilom side effects includes most common stomach upset, nausea, dizziness, and/or diarrhea. If any of these effects shown, ask your doctor or pharmacist promptly.
Keep in mind that your doctor has endorsed this medicine since the person has judged that the benefit to you is more prominent than the risk of side effects. Numerous individuals utilizing this Artrilom don’t serious side effects.
Artrilom can increase your blood pressure. Check your blood pressure routinely and tell your doctor if the outcomes are high.
Consult your doctor immediately if you see any serious side effects, including simple wounding/bleeding, severe headache, mental changes, abrupt weight gain, swelling of the hands/feet, indications of kidney issues, (for example, change in the amount of pee), unexplained hardened neck, unordinary tiredness.
This medication may once in a while cause serious liver sickness. Get therapeutic help immediately in the event that you have any side effects of liver harm, including dull pee, diligent nausea/spewing/loss of appetite, stomach/stomach torment, yellowing eyes/skin.
An intense unfavorably allergic reaction to this medication is rare. Be that as it may, get medicinal help immediately if you see any symptoms of a serious allergic reaction, including rash, tingling/swelling (particularly of the face/tongue/throat), extreme tipsiness, trouble in breathing.
This is certainly not a total rundown of possible side effects. If you see different impacts not listed above, contact your specialist or drug specialist.
How to use Artrilom
Read the Medication Guide provided by your pharmacist before you start taking Artrilom and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually once daily. Drink a full glass of water (8 ounces/240 milliliters) with it unless your doctor tells you otherwise. Do not lie down for at least 10 minutes after taking this drug.
If you are taking the liquid form of this medication, shake the bottle gently before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
If you are taking the disintegrating tablet, do not remove the tablet from the packaging until you are ready to take it. With dry hands, peel back the foil to carefully remove the tablet. Do not push the tablet through the foil because doing so can damage it. Place the tablet on your tongue right away and allow it to dissolve. After the tablet has melted, it can be swallowed with or without liquid.
If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. The dosage is based on your medical condition and response to treatment. The lowest effective dosage should always be used, and only for the prescribed length of time. Do not take more of this medication than prescribed because higher doses increase the chance of stomach ulcers/bleeding.
Artrilom may come in different forms (such as tablet, capsule, liquid, disintegrating tablet). Do not switch between different forms without consulting your doctor.
It may take up to two weeks before you get the full benefit of this drug. Use this medication regularly to get the most benefit from it. Remember to use it at the same time each day.
Tell your doctor if your condition worsens.
Artrilom is not a substitute for low dose aspirin for cardiovascular protection. ACE Inhibitors , Angiotensin Receptor Blockers , or Beta - Blockers Clinical Impact :
NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol). In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Intervention :
During concomitant use of Artrilom and ACE inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. During concomitant use of Artrilom and ACE inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function, monitor for signs of worsening renal function . When these drugs are administered concomitantly, patients should be adequately hydrated. Assess renal function at the beginning of the concomitant treatment and periodically thereafter. Diuretics
Clinical Impact :
Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis. However, studies with furosemide agents and Artrilom have not demonstrated a reduction in natriuretic effect. Furosemide single and multiple dose pharmacodynamics and pharmacokinetics are not affected by multiple doses of Artrilom. Intervention :
During concomitant use of Artrilom with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects . Lithium Clinical Impact :
NSA >see Clinical Pharmacology ( 12 . 3 )]. Intervention :
During concomitant use of Artrilom and lithium, monitor patients for signs of lithium toxicity. Methotrexate Clinical Impact : Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction). Intervention : During concomitant use of Artrilom and methotrexate, monitor patients for methotrexate toxicity. Cyclosporine
Clinical Impact : Concomitant use of Artrilom and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention : During concomitant use of Artrilom and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates
Clinical Impact : Concomitant use of Artrilom with other NSA >see Warnings and Precautions ( 5 . 2 )]. Intervention : The concomitant use of Artrilom with other NSAIDs or salicylates is not recommended. Pemetrexed
Clinical Impact : Concomitant use of Artrilom and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information). Intervention : During concomitant use of Artrilom and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity. Patients taking Artrilom should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration. In patients with creatinine clearance below 45 mL/min, the concomitant administration of Artrilom with pemetrexed is not recommended.
Carcinogenesis, Mutagenesis, Impairment of Fertility
There was no increase in tumor incidence in long-term carcinogenicity studies in rats (104 weeks) and mice (99 weeks) administered Artrilom at oral doses up to 0.8 mg/kg/day in rats and up to 8.0 mg/kg/day in mice (up to 0.5-and 2.6-times, respectively, the maximum recommended human dose of 15 mg/day Artrilom based on body surface area comparison).
Artrilom was not mutagenic in an Ames assay, or clastogenic in a chromosome aberration assay with human lymphocytes and an in vivo micronucleus test in mouse bone marrow.
Impairment of Fertility
Artrilom did not impair male and female fertility in rats at oral doses up to 9 mg/kg/day in males and 5 mg/kg/day in females (up to 5.8- and 3.2-times greater, respectively, than the MRHD based on BSA comparison).