What if I take too much?
Ask your doctor for advice straight away. Taking too much Amizepin by accident can lead to serious side effects.
6. How to cope with s >
What to do about:
- feeling sleepy, dizzy or tired - do not drive or use tools or machinery if you're feeling this way. Try to avoid drinking alcohol as this will make you feel more tired. If you feel dizzy, stop what you are doing and sit or lie down until you feel better. As your body gets used to Amizepin, these side effects should wear off. If they don't go after a few weeks, speak to your doctor.
- feeling or being sick - stick to simple meals and do not eat rich or spicy food while you're taking this medicine. It might help to take your Amizepin after you've had a meal or snack. If you're being sick, try having small, frequent sips of water or squash to avoid dehydration. Do not take any other medicines to treat vomiting without speaking to a pharmacist or doctor.
- headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if headaches last longer than a week or are severe.
- dry mouth - try chewing sugar-free gum or sucking sugar-free sweets.
- putting on weight - try to eat a healthy balanced diet without increasing your portion sizes. Do not snack on foods that contain a lot of calories, such as crisps, cakes, biscuits and sweets. If you feel hungry between meals, eat fruit and vegetables and low-calorie foods. Regular exercise will also help to keep your weight stable.
Drug-drug interactions are common with Amizepin , due to relatively high protein binding (65–80%), and involvement of drug metabolizing enzymes, including CYP2C19 and CYP3A4. Amizepin is primarily eliminate via the kidneys, thus renal failure or insufficiency can lead to elevated results and increase the risk for toxicity.
Amizepin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- thinking abnormal
- difficulty speaking
- uncontrollable shaking of a part of the body
- dry mouth
Do not stop taking Amizepin, unless your doctor tells you to.
You can take Amizepin as normal before and after surgery.
Amizepin may reduce the effects of some muscle relaxants so these may need to be increased.
Tell your doctor you are on Amizepin if you need surgery.
Amizepin does not affect female fertility, however, there have been rare reports of impaired male fertility. Speak to your doctor if you have any concerns.
Amizepin might stop these contraceptives from working:
- combined hormonal contraceptives (the combined pill, patches, and vaginal ring). Look out for bleeding between periods, which might be a sign the pill isn't working. Talk to your doctor if this happens. Your doctor may advise you to use a different type of contraceptive, or condoms as well as combined hormonal contraception.
- progestogen-only contraceptive pill or implants. Your doctor may advise you to use a different type of contraceptive that is not affected by Amizepin.
- emergency contraception - tell your doctor or pharmacist that you take Amizepin if you need emergency contraception. You may need an increased dose or to use a coil.
You can use the contraceptive injection or coil with Amizepin.
If you have epilepsy, you're entitled to free prescriptions for all of your medicines (not just your epilepsy ones).
To claim your free prescriptions you'll need a medical exemption certificate.
The application form for the medical exemption certificate is called FP92A. You can get this from your doctor's surgery. You will need to fill in the form, then your doctor will sign it and send it off.
Drinking alcohol while taking Amizepin may make you feel sleepy or tired. It's best to stop drinking alcohol for the first few days, until you see how the medicine affects you.
If you do drink, try not to have more than the recommended guidelines of up to 14 units of alcohol a week. A standard glass of wine (175ml) is 2 units. A pint of lager or beer is usually 2 to 3 units of alcohol.
Do not drink grapefruit juice if you're taking Amizepin. It increases the concentration of Amizepin in your body and increases the risk of side effects.
You may feel sleepy, tired or dizzy when you first start taking Amizepin. This may also happen if your dose has increased. If you're affected, do not drive, ride a bike, or operate machinery until you feel more alert.
If you have epilepsy, you're not allowed to drive until you've had no seizures for 1 year.
You are also not allowed to drive for 6 months after you change your epilepsy medicine.
References updated: 15 January 2017
4 months after starting Amizepin, with normal values for 8 years thereafter: adaptation vs incidental toxicity of concurrent organic solvent exposure).
12 mg/dL, ALT 570 U/L, Alk P 1332 U/L, protime 35%], ultimately resolving after 2-3 months despite delay in stopping drug: Case 4).
50,000 liver transplants done in the US between 1990 and 2002, 137 were done for idiosyncratic drug induced acute liver failure, of which 10 were attributed to phenytoin, 10 to valproate and 1 to Amizepin, but none to other anticonvulsants).
18% among tolerant patients and a similar rate in those with macular papular rashes).
17 mg/dL, ALT 1420 U/L, Alk P 610 U/L], resolving with corticosteroid therapy within 3 weeks of stopping).
Agents That May Affect Tegretol Plasma Levels
When Amizepin is given with drugs that can increase or decrease Amizepin levels, close monitoring of Amizepin levels is indicated and dosage adjustment may be required.
Other Drug Interactions
Cyclophosphamide is an inactive prodrug and is converted to its active metabolite in part by CYP3A. The rate of metabolism and the leukopenic activity of cyclophosphamide are reportedly increased by chronic coadministration of CYP3A4 inducers. There is a potential for increased cyclophosphamide toxicity when coadministered with Amizepin.
- Concomitant administration of Amizepin and lithium may increase the risk of neurotoxic side effects.
- Concomitant use of Amizepin and isoniazid has been reported to increase isoniazid-induced hepatotoxicity.
- Alterations of thyroid function have been reported in combination therapy with other anticonvulsant medications.
- Concomitant use of Tegretol with hormonal contraceptive products (e.g., oral, and levonorgestrel subdermal implant contraceptives) may render the contraceptives less effective because the plasma concentrations of the hormones may be decreased. Breakthrough bleeding and unintended pregnancies have been reported. Alternative or back-up methods of contraception should be considered.
- Resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents pancuronium, vecuronium, rocuronium and cisatracurium has occurred in patients chronically administered Amizepin. Whether or not Amizepin has the same effect on other non- depolarizing agents is unknown. Patients should be monitored closely for more rapid recovery from neuromuscular blockade than expected, and infusion rate requirements may be higher.
Taking tacrolimus with Amizepin will change the levels of tacrolimus in your body. Your doctor may monitor your blood levels of tacrolimus and change your dosage.