Interactions that increase your risk of side effects
Side effects from Amigrenin: Taking Amigrenin with certain medications raises your risk of side effects from Amigrenin. Examples of these drugs include:
- Tricyclic antidepressants, such as amitriptyline. You’re at higher risk of developing a serious condition called serotonin syndrome if you take these drugs. Symptoms can include agitation, sweating, fast heartbeat, or hallucinations (seeing or hearing things that aren’t real). They can also include nausea, vomiting, diarrhea, or loss of balance.
- Selective serotonin reuptake inhibitors used to treat depression, such as sertraline or fluoxetine. You’re at higher risk of developing a serious condition called serotonin syndrome if you take these drugs. Symptoms can include agitation, sweating, fast heartbeat, or hallucinations (seeing or hearing things that aren’t real). They can also include nausea, vomiting, diarrhea, or loss of balance.
- Serotonin and norepinephrine reuptake inhibitors, such as venlafaxine or duloxetine. You’re at higher risk of developing a serious condition called serotonin syndrome if you take these drugs. Symptoms can include agitation, sweating, fast heartbeat, or hallucinations (seeing or hearing things that aren’t real). They can also include nausea, vomiting, diarrhea, or loss of balance.
- Medications used to control headache pain, such as dihydroergotamine, codeine, or hydrocodone. Using too many medications to help control your headache symptoms may make your headache worse. Talk with your doctor about which medications to take to help manage your headache symptoms.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Amigrenin oral tablet comes with several warnings
Drugs you should not use with Amigrenin
Do not take these drugs with Amigrenin. Doing so can cause dangerous effects in the body. Examples of these drugs include:
- Monoamine oxidase-A inhibitors (MAOIs), such as phenelzine, isocarboxazid, or tranylcypromine. Taking these drugs with Amigrenin can cause a severe condition called serotonin syndrome. Symptoms can include agitation, sweating, fast heartbeat, or hallucinations (seeing or hearing things that aren’t real). They can also include nausea, vomiting, diarrhea, or loss of balance.
- Ergot-containing drugs, such as dihydroergotamine or methysergide. Taking these drugs with Amigrenin raises your risk of certain side effects, such as tightness or pressure in your chest. Don’t take these medications if you’ve taken Amigrenin in the last 24 hours.
- Other serotonin-1 receptor agonists, such as almotriptan or zolmitriptan. Taking these drugs with Amigrenin raises your risk of certain side effects, such as tightness or pressure in your chest. Don’t take these medications if you’ve taken Amigrenin in the last 24 hours.
What is Amigrenin? What are the uses for Amigrenin?
Amigrenin is a drug that is used for treating migraine headaches. It belongs to a class of drugs called selective serotonin receptor agonists. Other members of this class include naratriptan (Amerge), zolmitriptan (Zomig), rizatriptan (Maxalt), frovatriptan (Frova), eletriptan (Relpax), and almotriptan (Axert).
Migraine headaches are believed to result from dilatation of blood vessels in the brain. Amigrenin relieves migraines by stimulating serotonin receptors in the brain which cause the muscles surrounding the blood vessels in the brain to contract and narrow the blood vessels. At the same time, it also reduces transmission of pain signals by nerves to the brain. While it is very effective in relieving migraine headaches, it does not prevent or reduce the number of headaches. The FDA approved Amigrenin in December 1992.
More common side effects
The more common side effects that can occur with use of Amigrenin tablets include:
- feeling warm or cold
- tingling or prickling sensations in your skin
- pressure or pain in your chest, neck, jaw, or throat
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
What Is Amigrenin and How Does It Work?
Amigrenin is indicated for the acute treatment of migraine, with or without aura, and the acute treatment of cluster headache.
Amigrenin is available under the following different brand names: Imitrex, Imitrex Statdose, Sumavel DosePro, Alsuma, and Zembrace SymTouch.
Limitations of Use:
- Use only if a clear diagnosis of migraine or clusterheadache has been established. If a patient has no response to the first migraine or cluster headache attack treated with Amigrenin injection, reconsider the diagnosis before Amigrenin injection is administered to treat any subsequent attacks
- Amigrenin injection is not indicated for the prevention of migraine or cluster headache attacks
Dosages of Amigrenin:
Dosage Forms and Strengths
Injectable SC solution
Prefilled SC syringe/cartridge
- 3mg/0.5mL autoinjector (Zembrace SymTouch)
- 4mg/0.5mL (Imitrex StatDosePen)
- 6mg/0.5mL (Imitrex StatDosePen; Sumavel DosePro; Alsuma Autoinjector)
Dosage Considerations – Should be Given as Follows:
- 25 mg, 50 mg, or 100 mg orally (taken with fluids)
- Not to exceed 100 mg/dose; additional doses every 2 hours as needed
- Recommended maximum dose: 200 mg/day
- See also combo with naproxen
- 6 mg (0.5 mL) subcutaneously (SC) with autoinjector; may repeatin 1 hour or more
- Not to exceed 12 mg SC every 24 hours
- Dose may be reduced to 1-5 mg under certain circumstances; e.g., adverse reactions
- 6 mg (0.5 mL) subcutaneously (SC) with autoinjector; may repeat in 1 hour or more
- Not to exceed 12 mg SC every 24 hours
- Dose may be reduced under certain circumstances; e.g., adverse reactions
- Mild to moderate hepatic impairment: Oral not to exceed 50 mg/dose; no dosage adjustments necessary if administered subcutaneously (SC) (use with caution)
- Severe hepatic impairment: Contraindicated
- Children under 18 years: Safety and efficacy not established
- Geriatric use not recommended (higher incidence of adverse effects)
Examples of Amigrenin in a Sentence
These example sentences are selected automatically from various online news sources to reflect current usage of the word 'Amigrenin.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.
Elderly: -Dose selection for the older patient should be cautious, generally starting at the lower end of the dosing range due to a greater frequency of hepatic, renal, cardiac impairment as well as presence of concomitant disease or drug therapy.
For patients initiating therapy with subcutaneous injections: -If migraine returns after an initial dose of subcutaneous injection, additional oral doses may be given up to 100 mg orally per day, with at least a 2 hour interval between tablet doses.
For patients initiating therapy with Xsail(R) Breath Powdered Delivery Device: -If migraine returns after an initial intranasal dose, 1 dose of another Amigrenin product may be given as long as at least 2 hours has elapsed since intranasal administration.
Generic Name: Amigrenin succinate Dosage Form: tablet
Medically reviewed by Drugs.com. Last updated on Oct 1, 2018.
Amigrenin Succinate Tablets
Q: I have migraines. Why isn't there a generic or less expensive form of Imitrex available in U.S. pharmacies? I have been using Imitrex since it was first introduced for my migraines, and it has been a wonder drug for me. But because of the price, I am slow to take one at the onset of a migraine.
A: Your question regards if there is a generic available for Imitrex (Amigrenin) //www.everydayhealth.com/drugs/imitrex in U.S. pharmacies. There is a generic available for Imitrex called Amigrenin. Talk to your pharmacist about Amigrenin. You may also find helpful information about migraine headaches at //www.everydayhealth.com/migraine/guide/. Jen Marsico, RPh
What brand names are available for Amigrenin?
Imitrex, Alsuma, Imitrex STATdose System, Sumavel DosePro
If you experience any of the following symptoms, call your doctor immediately:
chest pain (severe) changes in skin color on face convulsions (seizures) fast or irregular breathing puffiness or swelling of eyelids, area around the eyes, face, or lips shortness of breath, troubled breathing or wheezing
Other side effects than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What storage conditions are needed for this medicine?
Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Please remember to throw away any medication that is outdated or no longer needed. If necessary, talk to your pharmacist about the proper disposal of your medication.
In case of an emergency/overdose
Should an overdose occur whilst taking Amigrenin, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.