Amiasten tablets


  • Active Ingredient: Pyridostigmine
  • 60 mg
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What is Amiasten?

The active ingredient of Amiasten brand is pyridostigmine. Pyridostigmine affects chemicals in the body that are involved in the communication between nerve impulses and muscle movement. Pyridostigmine bromide, USP is a white or almost white crystalline, deliquescent powder. It is very soluble in water and in alcohol, slightly soluble in hexane, practically insoluble in ether. Each Pyridostigmine bromide tablet, USP intended for oral administration contains 60 mg of Pyridostigmine bromide, USP. In addition, each tablet contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, low substituted hydroxypropyl cellulose, silicon dioxide and stearic acid.

Used for

Amiasten is used to treat diseases such as: Dysautonomia, Myasthenia Gravis, Nerve Agent Pretreatment, Reversal of Nondepolarizing Muscle Relaxants.

Side Effect

Possible side effects of Amiasten include: ; ; ; ; ; .

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The side effects of Mestinon (Amiasten) are most commonly related to overdosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness. Muscarinic side effects can usually be counteracted by atropine, but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the bromide radical, a skin rash may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication.

Read the entire FDA prescribing information for Mestinon (Amiasten)

How should this medicine be used?

Amiasten comes as a regular tablet, an extended-release (long-acting) tablet, and a syrup to take by mouth. It usually is taken once, twice, or several times a day, depending on the type of tablet. Your doctor may change your dose, depending on how you respond to the drug. When you first start taking Amiasten, your doctor may want you to keep a daily record of the time you take each dose, how long you feel better after taking each dose, and if you have side effects. This record will help the doctor decide how much drug is best for you.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amiasten exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take Amiasten even if you feel well. Do not stop taking Amiasten without talking to your doctor.

Amiasten overdose can cause severe illness, including muscle weakness. It is very hard to tell the difference between too little and too much Amiasten. Call your doctor immediately if your symptoms become worse.

Where can I get more information?

Your pharmacist can provide more information about Amiasten.

Acebutolol Amiasten may increase the bradycardic activities of Acebutolol. Acetylcholine The risk or severity of adverse effects can be increased when Amiasten is combined with Acetylcholine. Aclidinium The therapeutic efficacy of Aclidinium can be decreased when used in combination with Amiasten. Agmatine The therapeutic efficacy of Agmatine can be decreased when used in combination with Amiasten. Alcuronium Amiasten may decrease the neuromuscular blocking activities of Alcuronium. Aldosterone The therapeutic efficacy of Amiasten can be decreased when used in combination with Aldosterone. Alprenolol Amiasten may increase the bradycardic activities of Alprenolol. Amantadine The therapeutic efficacy of Amantadine can be decreased when used in combination with Amiasten. Amifampridine The risk or severity of adverse effects can be increased when Amiasten is combined with Amifampridine. Amitriptyline The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Amiasten.

Why is this medication prescribed?

Amiasten is used to decrease muscle weakness resulting from myasthenia gravis.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking Amiasten

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Amiasten it is important that your doctor knows:

  • If you are pregnant or breastfeeding.
  • If you have asthma.
  • If you have any of the following conditions: epilepsy, Parkinson's disease, an overactive thyro >

What is oral Amiasten? What are the uses for oral Amiasten?

Amiasten (Mestinon) is an oral cholinesterase inhibitor. Acetylcholine is one of many neurotransmitters in our bodies. Neurotransmitters are chemicals that help our cells communicate with each other. Depending on the organ that it acts upon, acetylcholine produces different effects. One important function of acetylcholine is to produce muscle contractions and movement. In people with myasthenia gravis or people treated with neuromuscular blocking medicines there is a decrease in the levels of acetylcholine. In such cases Amiasten may be used to increase acetylcholine levels and improve muscle contraction or movement. Amiasten increases the concentration of acetylcholine at nerve junctions by inhibiting cholinesterase, the enzyme that destroys acetylcholine.

In comparison to neostigmine (Bloxiverz, Prostigmin), another cholinesterase inhibitor, Amiasten has a longer duration of action. Amiasten was approved by the FDA for the treatment of myasthenia gravis in 1955.

What are some things I need to know or do while I take Amiasten Injection?

  • Tell all of your health care providers that you take Amiasten injection. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not take more than what your doctor told you to take. Unsafe effects, including death, may happen.
  • This medicine is not approved for use in children. However, the doctor may decide the benefits of taking Amiasten injection outweigh the risks. If your child has been given Amiasten injection, ask the doctor for information about the benefits and risks. Talk with the doctor if you have questions about giving Amiasten injection to your child.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

What is Amiasten?

Amiasten affects chemicals in the body that are involved in the communication between nerve impulses and muscle movement.

Amiasten is used to treat the symptoms of myasthenia gravis. It is also used in military personnel who have been exposed to nerve gas.

Amiasten may also be used for purposes not listed in this medication guide.

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Cite this Entry

“Amiasten.” The Dictionary, Merriam-Webster Inc., Accessed 27 December 2019.

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What other drugs will affect Amiasten?

Other drugs may interact with Amiasten, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.


Although Amiasten may be used for myasthenia gravis, it may improve orthostatic hypotension. It has been used in combination with midodrine and fludrocortisone to treat patients with orthostatic hypotension and postural orthostatic tachycardia syndrome. These indications are off label.

For orthostatic hypotension and postural orthostatic tachycardia syndrome, low-dose therapy is generally recommended at a dose of 60 mg PO twice a day.


Amiasten , neostigmine, and edrophonium all contain a quaternary ammonium group, limiting lipid solubility and preventing passage through the blood-brain barrier. Physostigmine lacks the quaternary ammonium group enabling it to pass freely into the CNS. 170 The longer-acting agents, Amiasten, neostigmine, and physostigmine, contain a carbamate group that forms a reversible covalent bond with acetylcholinesterase. Edrophonium, lacking a carbamate group, forms short-lived electrostatic and hydrogen bonds with acetylcholinesterase, accounting for its shorter activity.

Before taking Amiasten,

  • tell your doctor and pharmacist if you are allergic to Amiasten, bromides, or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially allergy or cold medications, dexamethasone (Decadron), hydrocortisone (Hydrocortone), magnesium-containing products, medications for heart arrhythmias, sleeping pills, and vitamins.
  • tell your doctor if you have or have ever had intestinal or bladder blockage, asthma, seizures, heart or kidney disease, thyroid problems, or stomach ulcers.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Amiasten, call your doctor.
  • you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
  • remember that alcohol can add to the drowsiness caused by this drug.


Amiasten bromide (Mestinon) is a drug prescribed to treat myasthenia gravis. Side effects, drug interactions, warnings, precautions, storage, dosage, breasstfeeding, and pregnancy safety for Mestinon is included.

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