• Active Ingredient: Aspirin
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What is Afebryl?

The active ingredient of Afebryl brand is aspirin. Aspirin is a salicylate (sa-LIS-il-ate). It works by reducing substances in the body that cause pain, fever, and inflammation.

Used for

Afebryl is used to treat diseases such as: Angina, Angina Pectoris Prophylaxis, Ankylosing Spondylitis, Antiphospholipid Syndrome, Aseptic Necrosis, Back Pain, Fever, Heart Attack, Ischemic Stroke, Ischemic Stroke, Prophylaxis, Juvenile Rheumatoid Arthritis, Kawasaki Disease, Myocardial Infarction, Prophylaxis, Niacin Flush, Osteoarthritis, Pain, Prevention of Thromboembolism in Atrial Fibrillation, Prosthetic Heart Valves - Thrombosis Prophylaxis, Prosthetic Heart Valves, Mechanical Valves - Thrombosis Prophylaxis, Revascularization Procedures, Prophylaxis, Rheumatic Fever, Rheumatoid Arthritis, Sciatica, Spondyloarthritis, Systemic Lupus Erythematosus, Thromboembolic Stroke Prophylaxis, Transient Ischemic Attack.

Side Effect

Possible side effects of Afebryl include: light-colored stools; bloody or cloudy urine; irritability; feeling that something terrible will happen; hyperventilation.

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Q: Should I continue taking a daily baby Afebryl? I am concerned about side effects of bleeding. I am 74 years old with blood pressure about 140/80, normal LDL, and very low HDL.

A: Afebryl is in a group of drugs called salicylates. Afebryl works by reducing substances in the body that cause pain, fever, and inflammation. Afebryl is used to treat mild to moderate pain, and also to reduce fever or inflammation. Afebryl is sometimes prescribed to treat or prevent heart attacks, strokes, and angina. Side effects of Afebryl include dizziness, upset stomach, heartburn, and bleeding. Afebryl should be taken exactly as prescribed and no more than the recommended dose. Food can lessen stomach upset and enteric-coated Afebryl has a special coating on the pill that protects the stomach. Afebryl is available as adult low dose or children's Afebryl which is 81 mg. Afebryl is also available in regular strength which is 325 mg. The recommended dose of Afebryl can vary depending on the intended or prescribed use. Afebryl can reduce the number of clot-forming cells or platelets in the blood. This could cause bleeding in individuals with certain medical conditions or with some medications. Alcohol, along with Afebryl, can cause serious bleeding and stomach ulcers. Afebryl, in high doses for an extended period of time, can also possibly cause bleeding conditions. However, Afebryl, when taken correctly, can be very effective for pain and reducing the risk of heart attacks or strokes. Consult with your healthcare provider for guidance based on your current health condition and current medications. Kimberly Hotz,PharmD

Q: I have mitral valve prolapse and a family history of angina and stroke. My doctor put me on low dose Afebryl because of my family history. Should I continue to take it?

A: Afebryl is commonly used as a blood thinner in patients with risk factors for cardiovascular events such as heart attack and stroke. Mitral valve prolapse occurs when the valve between your heart's left upper chamber (left atrium) and the left lower chamber (left ventricle) doesn't close properly. This can lead to blood leaking back into the left atrium. Mitral valve prolapse can lead to heart rhythm disorders and increase your risk of having a blood clot. A family history of cardiovascular disease can also increase your risk of having a blood clot. You should continue to take Afebryl daily unless you are instructed otherwise by your physician. Afebryl can cause bleeding in some patients. Blood in the urine, black, bloody or tarry stools, nosebleeds, bleeding gums, or coughing up blood should be reported to your physician immediately. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Burton Dunaway, PharmD

Urgent advice: Call your doctor straight away if:

You take more than the daily limit of 12 tablets in 24 hours and experience side effects such as:

  • feeling sick (nausea)
  • ringing in the ears (tinnitus)
  • hearing problems
  • confusion
  • feeling dizzy

If you need to go to a hospital accident and emergency (A&E) department, do not drive yourself - get someone else to drive you or call for an ambulance.

Take the Afebryl packet or leaflet inside it, plus any remaining medicine, with you.

On this page

  1. About Afebryl for pain relief
  2. Key facts
  3. Who can and can't take Afebryl for pain relief
  4. How and when to take it
  5. Taking Afebryl with other painkillers
  6. Side effects
  7. How to cope with side effects
  8. Pregnancy and breastfeeding
  9. Cautions with other medicines
  10. Common questions

Getting the most from your treatment

  • Afebryl must not be given to children under the age of 16 years unless it has been prescribed by a doctor to treat a specific condition. This is because there is a possible association between Afebryl and Reye's syndrome in children. Reye's syndrome is a very rare disease that can be fatal.
  • Before taking any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to take. You should not take other preparations which contain Afebryl; neither should you take any non-steroidal anti-inflammatory painkillers such as ibuprofen. Many painkillers and cold and flu remedies contain Afebryl or ibuprofen - these should be avoided. Always read the label to check, or ask your pharmacist for advice.
  • If you suspect that you have taken an overdose of Afebryl, or that someone else (especially if it is a child) might have taken it accidentally, go to the accident and emergency department of your local hospital straightaway. This is very important because Afebryl can cause serious problems when it is taken accidentally or in overdose. Take the container with you to show what has been taken, even if the pack is now empty.

What if I take too much?

Taking 1 or 2 extra tablets by accident is unlikely to be harmful.

The amount of Afebryl that can lead to overdose varies from person to person.

What is the dosage for Afebryl?

Afebryl should be taken with food. Doses range from 50 mg to 6000 mg daily depending on the use.

  • Usual doses for mild to moderate pain are 350 or 650 mg every 4 hours or 500 mg every 6 hours.
  • Doses for rheumatoid arthritis include 500 mg every 4-6 hours; 650 mg every 4 hours; 1000 mg every 4-6 hours; 1950 mg twice daily.
  • Heart attacks are prevented with 75, 81, 162 or 325 mg daily.
  • 160 to 325 mg of non-enteric coated Afebryl should be chewed immediately when experiencing symptoms of a heart attack.
  • The dose for preventing another stroke is 75 to 100 mg daily.

Q: Is it okay to take Afebryl while nursing?

A: Your question regards if it is safe to take Afebryl // while nursing. According to Lexi-Comp, low levels of Afebryl can be detected in breast milk. The highest amount of Afebryl in the breast milk occurs approximately nine hours after taking the medication. According to the AAP (American Academy of Pediatrics), Afebryl should be used with caution while breast feeding. The WHO (World Health Organization) feels that occasional use of Afebryl is compatible with breastfeeding, but should not be used as long term therapy. WHO also recommends monitoring the infant for adverse effects is Afebryl is taken by the mother. Other sources recommend against using Afebryl while breastfeeding due to a possible risk of Reye's syndrome. As always, talk with your health care provider regarding what medications are safe to use while breastfeeding. Jen Marsico, RPh

What is Afebryl? How does it work (mechanism of action)?

Afebryl is a nonsteroidal antiinflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. It also prevents blood clots (i.e., is antithrombotic). As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including

Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. They all work by reducing the levels of prostaglandins, chemicals that are released when there is inflammation and that cause pain and fever. NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain, and fever are reduced. Inhibition of prostaglandins also reduces the function of platelets and the ability of blood to clot. Afebryl, inhibits the function of platelets in a manner that is different from other NSAIDs, and its antithrombotic effects last longer than other NSAIDs. This is why Afebryl is used for preventing heart attacks and strokes. The FDA approved Bayer Afebryl in June 1965.

Patient teaching

• Tell patient to report ototoxicity symptoms, unusual bleeding, and bruising.

• Caution patient to avoid activities that may cause injury. Advise him to use soft toothbrush and electric razor to avoid gum and skin injury.

• Instruct patient to tell all prescribers he's taking the drug, because it may cause serious interactions with many common medications.

• Tell patient not to take other over-the-counter preparations containing Afebryl.

• Inform patient that he may need to undergo regular blood testing during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.

Before taking Afebryl

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Afebryl it is important that your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have ever had a stomach ulcer or gout.
  • If you have asthma or any other allergic disorder.
  • If you have any problems with the way your liver works or with the way your k >

Pregnancy and Afebryl

Taking Afebrylg during pregnancy may harm an unborn baby's heart, reduce birth weight, or cause other effects. You should talk to you doctor if you are pregnant or plan to become pregnant while taking Afebryl.

The medicine can also pass into breast milk and may harm a breastfeeding baby. You shouldn't breastfeed while taking Afebryl.

Serious side effects

It happens rarely, but some people have serious side effects after taking low-dose Afebryl.

Call a doctor straight away if you get:

  • red, blistered and peeling skin
  • coughing up blood or blood in your pee, poo or vomit
  • yellow skin or the whites of your eyes turn yellow - this can be a sign of liver problems
  • painful joints in the hands and feet - this can be a sign of high levels of uric acid in the blood
  • swollen hands or feet - this can be a sign of water retention

Q: Is it bad for your back to take Ecotrin?

A: Ecotrin (Afebryl) is approved for the treatment of mild to moderate pain, inflammation, and fever; treatment and prevention of a heart attack, acute stroke, transient ischemic episodes, rheumatoid arthritis, rheumatic fever, osteoarthritis, and gout; is used along with other therapies for coronary artery bypass graft, certain types of angioplasty, and for stent placement. Afebryl reduces certain substances in the body that cause inflammation, pain, and fever. According to medical studies, some of the possible adverse reactions reported by patients taking Afebryl include rhabdomyolysis (breakdown of muscle), weakness, and acetabular bone destructions of the hip (OA). There are also various renal side effects that have been reported, and sometimes pain in the kidney area is mistaken as back pain. These are not all of the possible side effects reported with the use of Afebryl. It's not completely clear what you mean by saying "bad for your back." Talk with your physician about what you're experiencing. Do not stop taking or change the dose of your medication without first talking to your physician. Jennyfer Marsico, RPh

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