Zyzapin tablets


  • Active Ingredient: Olanzapine
  • 7.5 mg, 5 mg, 2.5 mg
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What is Zyzapin?

The active ingredient of Zyzapin brand is olanzapine. Olanzapine is an antipsychotic medication that affects chemicals in the brain.

Used for

Zyzapin is used to treat diseases such as: Agitated State, Agitation, Anorexia, Anorexia Nervosa, Asperger Syndrome, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Depression, Insomnia, Major Depressive Disorder, Nausea/Vomiting, Chemotherapy Induced, Obsessive Compulsive Disorder, Paranoid Disorder, Schizoaffective Disorder, Schizophrenia, Tourette's Syndrome.

Side Effect

Possible side effects of Zyzapin include: leg cramps; difficult or labored breathing; shuffling walk; tic-like (jerky) movements of the head, face, mouth, and neck; hoarseness; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; loss of memory; change in walking and balance.

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How should I take Zyzapin?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take Zyzapin in larger or smaller amounts or for longer than recommended.

Zyzapin can be taken with or without food.

Zyzapin is usually taken once a day. Zyzapin may be only part of a complete program of treatment that also includes counseling and other psychological support programs. Follow your doctor's instructions.

To take Zyzapin orally disintegrating tablet (Zyprexa Zydis):

Keep the tablet in its original container until you are ready to take it.

Using dry hands, place the tablet in your mouth. It will begin to dissolve right away.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, or if they get worse while using Zyzapin.

Do not stop using Zyzapin suddenly, even if you feel fine. Stopping suddenly may cause serious side effects.

Zyzapin can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking Zyzapin.

You may gain weight or have high cholesterol and triglycerides (types of fat) while taking this medicine, especially if you are a teenager. Your blood may need to be tested often. Visit your doctor regularly.

If you are taking a combination of drugs, use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Store at room temperature away from moisture, heat, and light.

WHAT IS Zyzapin?

Zyzapin is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

This medication is used to treat psychotic mental disorders, such as schizophrenia, bipolar disorder, and agitation that occurs with schizophrenia and bipolar mania.

Zyzapin should not be administered to treat behavioral problems in older adult patients who have dementia.

How to store Zyzapin

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.


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Below you will find images and specific information on the principal types of Zyzapin that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

How to use Zyzapin

Read the Medication Guide provided by your pharmacist before you start taking Zyzapin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication as prescribed even if you feel well. Do not stop taking this medication without consulting your doctor.

Tell your doctor if your condition persists or worsens.

Zyzapin belongs to a group of medicines called antipsychotics. It may have been prescribed for you to relieve the symptoms of schizophrenia, or alternatively, it may have been prescribed for the treatment and/or prevention of high mood swings (mania). In both of these conditions, Zyzapin works on the balance of chemical substances in your brain.

Zyzapin (Zyprexa)

Zyzapin is a thienobenzodiazepine structurally similar to clozapine that received FDA approval in 1997 and in 2004 was approved for the long-term treatment of bipolar disorder. Zyzapin is also available in a combined preparation with fluoxetine. Like other SGAs, selectivity for D 2-dopamine receptors is significantly less than for FGAs, although it does have relatively greater selectivity for D2 than does clozapine. Antagonist affinity for the 5-HT2A receptor is greater than for dopamine receptors, while affinity for the 5-HT2C receptor is similar to that for D2. There is also antagonism of α1-adrenergic, H1-histaminergic, and M1-5 muscarinic receptors. Zyzapin also has weak activity at GABAA receptors. Although interaction with GABAergic anesthetics is not defined, Zyzapin is considered to potentiate the effects of benzodiazepines, and fatalities from cardiorespiratory depression have been reported when intramuscular Zyzapin has been combined with benzodiazepines. 101 Zyzapin is highly protein bound and predominantly metabolized by CYP 1A2.

Zyzapin is associated with weight gain, diabetogenesis, and dyslipidemia, with an incidence and magnitude greater than other SGAs or FGAs. 102,103 Boxed warnings exist for increased risk of death in older patients receiving Zyzapin for dementia-related psychosis, and for excessive sedation and delirium following intramuscular injection. The incidence of EPS is less than that of the FGAs, but greater than that with clozapine. Although a small number of cases of Zyzapin-induced leukopenia and agranulocytosis have been reported, scheduled monitoring is not required. Similarly, while cardiac conduction abnormalities have been reported, myocarditis and cardiomyopathy are not features, and the overall cardiac risk is significantly less than that associated with clozapine.

What Are the Stages of the Zyzapin Withdrawal Timeline?

The timeline and stages of Zyzapin withdrawal can vary depending on the individual’s tolerance level, genetics, frequency of use and dosage. Whether or not Zyzapin was used in combination with other drugs or alcohol will also factor in the withdrawal timeline.

For some individuals who have taken the drug for extended periods of time, withdrawal symptoms may linger for upward of 90 days or more. For others, the withdrawal may only persist for a couple of weeks.

By working with a healthcare provider to wean off Zyzapin, individuals may not have any notable withdrawal symptoms at all. On the other hand, individuals who decide to quit “cold turkey” may find themselves really struggling with severe symptoms as their brain attempts to rewire itself to function without the drug.

Drug levels

Maternal Levels. A nursing mother was started on Zyzapin 20 mg daily on day 9 postpartum. Numerous milk Zyzapin levels collected over the subsequent 8 days ranged from 7.6 to 27.5 mcg/L. The authors calculated that an exclusively breastfed infant would receive 0.011 mg/kg daily or about 4% of the maternal weight-adjusted dosage.

Nine paired serum and milk levels were obtained from 5 mothers who were taking Zyzapin. In 2 women taking 10 mg daily, one had a milk level of 21 mcg/L 11 hours after the dose and the other had a milk level of 16 mcg/L 23 hours after the dose. In 3 women taking 2.5 mg daily, milk levels ranged from

Can I take Zyzapin while breastfeeding?

Maternal doses of Zyzapin up to 20 mg daily produce low levels in milk and undetectable levels in the serum of breastfed infants. In most cases, short-term side effects have not been reported, but sedation has occurred. Limited long-term follow-up of infants exposed to Zyzapin indicates that infants generally developed normally. A systematic review of second-generation antipsychotics concluded that Zyzapin seemed to be the first-line agent during breastfeeding. Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.

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