Zyloric tablets


  • Active Ingredient: Allopurinol
  • 300 mg
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What is Zyloric?

The active ingredient of Zyloric brand is allopurinol. Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. Each scored orange tablet contains 300 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. Its solubility in water at 37В°C is 80 mg/dL and is greater in an alkaline solution.

Used for

Zyloric is used to treat diseases such as: Calcium Oxalate Calculi with Hyperuricosuria, Cardiothoracic Surgery, Gout, Heart Failure, High Risk Percutaneous Transluminal Angioplasty, Hyperuricemia Secondary to Chemotherapy, Leishmaniasis, Mania, Reactive Perforating Collangenosis, Urinary Tract Stones.

Side Effect

Possible side effects of Zyloric include: muscle pain or stiffness; bleeding gums; vomiting of blood or material that looks like coffee grounds; thirst; body aches or pain.

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Rated Zyloric for Gout Report

i ralize this is not a review of the drug-this is in fact the contents of one sachet of urals if anyone is desparate. Sodium Bicarbonate 1.76 grams which is 3/8 of a teaspoon Citric Acid powder 0.72 grams which is 1/8 of a teaspoon Tartaric Acid pwdr 0.89 grams which is 1/8++ teaspoon Sodium Citrate 0.63 grams which is 1/8+ teaspoon i could not find anywhere else to put the info

Zyloric Dosage

The typical adult dose of Zyloric for gout is:

Initial Dose : 100 to 200 milligrams (mg), once a day.

Maintenance Dose : 200 to 300 mg orally, once a day, for mild gout or 400 to 600 mg a day in divided doses for moderately severe gout.

You should take each dose of Zyloric with a full glass of water. To reduce the risk of kidney stones forming, you should drink eight to 10 full glasses of fluid every day.

Read more about how to order Lizopril tablets for High Blood Pressure

Rated Zyloric for Gout Report

on a dose of 300 mg of Allopurinal as lower dose not effective. Tried several times this time taken for 6 months with side effects worsening.Serious side effects now. rash, boils , ulcers in mouth, weight gain, impotence. GP slow to resoond. stopping now to see what effect that has. Also on Steroids for Sarcoidosis and wondered if there was a drug interaction . No attacks of Gout for a while. waiting to see if stopping the drug brings it back

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to Zyloric.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Why is this medication prescribed?

Zyloric is used to treat gout, high levels of uric acid in the body caused by certain cancer medications, and kidney stones. Zyloric is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body. High levels of uric acid may cause gout attacks or kidney stones. Zyloric is used to prevent gout attacks, not to treat them once they occur.


Patients who have developed a severe reaction to ZYLOPRIM (Zyloric) should not be restarted on the drug.


Data upon which the following estimates of incidence of adverse reactions are made are derived from experiences reported in the literature, unpublished clinical trials and voluntary reports since marketing of ZYLOPRIM (Zyloric) began. Past experience suggested that the most frequent event following the initiation of Zyloric treatment was an increase in acute attacks of gout (average 6% in early studies). An analysis of current usage suggests that the incidence of acute gouty attacks has diminished to less than 1%. The explanation for this decrease has not been determined but may be due in part to initiating therapy more gradually (see PRECAUTIONS and DOSAGE AND ADMINISTRATION).

The most frequent adverse reaction to ZYLOPRIM (Zyloric) is skin rash. Skin reactions can be severe and sometimes fatal. Therefore, treatment with ZYLOPRIM (Zyloric) should be discontinued immediately if a rash develops (see WARNINGS). Some patients with the most severe reaction also had fever, chills, arthralgias, cholestatic jaundice, eosinophilia and mild leukocytosis or leukopenia. Among 55 patients with gout treated with ZYLO-PRIM for 3 to 34 months (average greater than 1 year) and followed prospectively, Rundles observed that 3% of patients developed a type of drug reaction which was predominantly a pru-ritic maculopapular skin eruption, sometimes scaly or exfolia-tive. However, with current usage, skin reactions have been observed less frequently than 1%. The explanation for this decrease is not obvious. The incidence of skin rash may be increased in the presence of renal insufficiency. The frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with ZYLOPRIM (Zyloric) has been reported to be increased (see PRECAUTIONS).

Most Common Reactions* Probably Causally Related:

Metabolic and Nutritional: Acute attacks of gout.

Skin and Appendages: Rash, maculopapular rash.

*Early clinical studies and incidence rates from early clinical experience with ZYLOPRIM (Zyloric) suggested that these adverse reactions were found to occur at a rate of greater than 1%. The most frequent event observed was acute attacks of gout following the initiation of therapy. Analyses of current usage suggest that the incidence of these adverse reactions is now less than 1%. The explanation for this decrease has not been determined, but it may be due to following recommended usage (see ADVERSE REACTIONS introduction, INDICATIONS AND USAGE, PRECAUTIONS, and DOSAGE AND ADMINISTRATION).

Incidence Less Than 1% Probably Causally Related:

Body As a Whole: Ecchymosis, fever, headache.

Hemic and Lymphatic: Thrombocytopenia, eosinophilia, leukocytosis, leukopenia.

Skin and Appendages: Erythema multiforme exudativum (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), hypersensitivity vasculitis, purpura, vesicular bullous dermatitis, exfoliative dermatitis, eczematoid dermatitis, pruritus, urticaria, alopecia, onycholysis, lichen planus.

Special Senses: Taste loss/perversion.

Incidence Less Than 1% Causal Relationship Unknown:

Skin and Appendages: Furunculosis, facial edema, sweating, skin edema.

Q: My last uric acid level was 7.5. Will Zyloric bring down uric acid levels?

A: Zyloric (Zyloprim) is a xanthine oxidase inhibitor that reduces the production of uric acid in your body. A uric acid buildup can lead to gout or kidney stones. Zyloric is used to treat gout. Common side effects of Zyloric include nausea, vomiting, diarrhea, dizziness, and joint pain. According to the prescribing information, Zyloric administration usually results in a decrease of uric acid within 2 to 3 days. However, it may take 1 week or more to see the full benefits. This is not a complete list of side effects associated with Zyloric, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kimberly Hotz, PharmD

By Julie Marks | Medically Reviewed by Mona Khanna, MD

Latest Update: 2014-10-20 Copyright © 2014 Everyday Health Media, LLC

Zyloric Warnings

Your doctor will likely start you on a low dose of Zyloric and gradually increase it. It may take several months before you feel the full benefits of this medicine. Zyloric may increase the number of gout attacks you experience during the first few months you take it, but it will eventually prevent the attacks from occurring.

You should tell your doctor if you have any of the following conditions before taking Zyloric:

Zyloric can decrease the number of blood cells in your body that make blood clot and that help you fight infections, which can make it easier for you to bleed from an injury or get sick when exposed to others who are ill. You should avoid being around people who are sick or have infections while taking this medicine.

See your doctor regularly while taking this drug. Your blood may need to be tested to check your body’s reaction to the medication.

Possible risks and s >

Side effects of taking Zyloric can include:

  • skin rashes
  • headaches
  • feeling drowsy or dizzy
  • feeling or being sick
  • changes to your sense of taste.

If you develop a rash, you should stop taking your Zyloric and contact your doctor straight away. If you become dizzy or drowsy while taking Zyloric, don’t drive or operate machinery, and see your doctor as soon as possible. You should also speak to your doctor if you develop any other new symptoms that concern you.

Most people who take Zyloric don’t get any side effects. But if you do have side effects, it may be possible to restart Zyloric using a special ‘desensitisation’ course. This involves beginning Zyloric at a very low dose and increasing the dose gradually.

Sometimes starting Zyloric can actually trigger an attack of gout, as the crystals begin to dissolve. You will probably be given an extra medicine for the first few months of taking Zyloric to reduce the risk of these attacks happening.

Acute attacks of gout are usually treated with a high dose of a non-steroidal anti-inflammatory drug (NSAID), such as:

  • diclofenac sodium (die-clo-fe-nac sow-dee-um)
  • diclofenac potassium (die-clo-fe-nac po-tass-ee-um)
  • etoricoxib (ee-torry-cox-ib)
  • indomethacin (in-doe-meth-a-sin)
  • ketoprofen (key-toe-pro-fen)
  • naproxen (na-procks-en)
  • sulindac (suh-lin-dak).

These drugs all have brand names, so the type you’re given may be called something different.

If you cannot take NSAIDs, colchicine (coal-chi-seen) or steroids may be given.

If you do have an acute attack of gout while on Zyloric, don’t stop taking it.

If you’re unable to continue taking Zyloric because of your side effects, you may be able to take febuxostat instead, which works in a similar way to Zyloric.

If you can’t take febuxostat, your doctor may suggest benzbromarone (bens-bro-ma-rone) or sulfinpyrazone (sul-fin-pira-zone).

However, Zyloric should not be used to treat an acute attack of gout. This is because they may make the attack last longer.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Severe skin rash. Symptoms can include:
    • itchy hives (raised bumps on your skin)
    • red or purple-colored spots on your skin
    • scaly skin
    • fever
    • chills
    • trouble breathing
    • swelling of your face or throat
  • tiredness
  • lack of appetite
  • weight loss
  • right upper abdominal area pain or discomfort
  • jaundice (dark-colored urine or yellowing of your skin or the whites of your eyes)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Zyloric oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

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