Zotrix tablets


  • Active Ingredient: Ondansetron
  • 8 mg, 4 mg
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What is Zotrix?

The active ingredient of Zotrix brand is ondansetron. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. The molecular formula is C18H19N3O•HCl•2H2O, representing a molecular weight of 365.9. Ondansetron HCl dihydrate is a white to off-white powder that is soluble in water and normal saline. Each 4 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 4 mg of Ondansetron. Each 8 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 8 mg of Ondansetron. Each tablet also contains the inactive ingredients croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, titanium dioxide, triacetin, and iron oxide yellow (8 mg tablet only). This product meets USP Dissolution Test 3.

Used for

Zotrix is used to treat diseases such as: Alcohol Dependence, Gastroenteritis, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Nausea/Vomiting, Radiation Induced, Obsessive Compulsive Disorder, Postanesthetic Shivering, Pruritus.

Side Effect

Possible side effects of Zotrix include: headache; unusual tiredness or weakness; shortness of breath; fast, pounding, or irregular heartbeat or pulse; Confusion; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; chest pain or discomfort; difficulty with swallowing.

How to Buy Zotrix tablets online?

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Before taking Zotrix, tell your doctor or pharmacist if you are allergic to it; or to other anti-nausea serotonin blockers (e.g., granisetron); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: irregular heartbeat, liver disease, stomach/intestinal problems (e.g., recent abdominal surgery, ileus, swelling).

Zotrix may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Zotrix, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Zotrix safely.

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

This medicine may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist regarding the safe use of this medicine.

Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Before taking Zotrix

You should not use Zotrix if:

you are also using apomorphine (Apokyn); or

you are allergic to Zotrix or similar medicines (dolasetron, granisetron, palonosetron).

To make sure Zotrix is safe for you, tell your doctor if you have:

an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

congestive heart failure, slow heartbeats;

a personal or family history of long QT syndrome; or

a blockage in your digestive tract (stomach or intestines).

Zotrix is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether Zotrix passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Zotrix is not approved for use by anyone younger than 4 years old.

Zotrix orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

Zotrix side effects

Get emergency medical help if you have signs of an allergic reaction to Zotrix: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe constipation, stomach pain, or bloating;

headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

fast or pounding heartbeats;

jaundice (yellowing of the skin or eyes);

blurred vision or temporary vision loss (lasting from only a few minutes to several hours);

high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

Common Zotrix side effects may include:

diarrhea or constipation;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In our latest question and answer, the pharmacist discusses how often you can safely take Zofran (Zotrix).

What Are Side Effects Associated with Using Zotrix ?

Side effects of Zotrix include:

Other side effects of Zotrix include:

  • heart rate irregularities (including ventricular and supraventricular tachycardia, premature ventricular contractions, and atrial fibrillation)
  • slow heart rate
  • electrocardiographic alterations (including second-degree heart block, QT/QTc interval prolongation, and ST segment depression)
  • palpitations
  • fainting (rarely and predominantly with intravenous Zotrix)
  • transient ECG changes including QT/QTc interval prolongation have been reported

  • ECG alterations: heart beat irregularities; prolongation of PR, QRS, and QT intervals

  • specific hepatic enzyme abnormalities
  • hepatic necrosis
  • abnormal hepatic function

  • flushing
  • rare cases of hypersensitivity reactions, sometimes severe (acute allergic reactions, rapid swelling, difficulty breathing, cardiopulmonary arrest, low blood pressure, laryngealedema, laryngospasm, shock, shortness of breath, or stridor)

  • pain, redness, and burning at injection site

  • involuntary intermittent or sustained deviation of the eyes, appearing alone, as well as with other dystonic reactions; transient dizziness during or shortly after intravenous infusion

  • Transient blindness (predominantly during IV administration) reported to resolve within a few minutes up to 48 hr;
  • transient blurred vision

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Interactions that increase your risk of side effects from Zotrix

Taking Zotrix with certain medications raises your risk of side effects from Zotrix. This is because the amount of Zotrix in your body may be increased. Examples of these drugs include:

  • Other drugs that affect serotonin levels, such as fluoxetine and paroxetine.

More common side effects

The more common side effects of Zotrix can include:

  • headache
  • diarrhea
  • constipation
  • dizziness
  • drowsiness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Can taking Zotrix during pregnancy cause other pregnancy complications?

Studies did not find a higher chance of miscarriage, premature delivery (being born before 37 weeks of pregnancy), or low birth weight when women used Zotrix during pregnancy.

At higher doses, there have been reports that Zotrix use might cause a heart rhythm problem (called QT interval prolongation) in the person taking Zotrix. In severe cases, this could become an abnormal heart rhythm known as Torsades de Pointes. You can discuss how to monitor for QT interval prolongation with your healthcare provider is you are using this medication.

Special dosage considerations

For people with liver disease: If you have severe liver disease, you should not take more than 8 mg of Zotrix per day.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Zotrix orally disintegrating tablet is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: You could have nausea and vomiting that’s not controlled.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • faintness
  • drowsiness
  • agitation
  • fast heartbeat
  • flushing (sudden reddening of the skin)
  • seizures

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

How to tell if the drug is working: You should not have nausea or vomiting. If you do, it should be less severe.

Keep these considerations in mind if your doctor prescribes Zotrix for you.

Zofran S >

The most common side effects of Zotrix are:

Serious side effects can occur. If you have any of these side effects, call your doctor right away:

  • Temporary blurred vision or loss of vision
  • Severe rash, hives, or a rash that causes blisters and peeling
  • Yellowing of skin or eyes or dark-colored urine
  • Seizure
  • Chest pain
  • Loss of consciousness
  • Swelling of face, lips, tongue, or other parts of the body
  • Difficulty breathing, swallowing, or talking

What should I avoid while taking Zotrix?

Zotrix may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Proper use of Zotrix

This section provides information on the proper use of a number of products that contain Zotrix. It may not be specific to Zofran ODT. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

  • Make sure your hands are dry.
  • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
  • Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

  • Make sure your hands are clean and dry before and after using this medicine.
  • Fold the pouch along the dotted line to expose the tear notch.
  • While still folded, tear the pouch carefully along the edge and remove the film out from the pouch.
  • Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole.
  • Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Does taking Zotrix increase the chance for miscarriage?

One study did not find a higher rate of miscarriage among women who reported using Zotrix in the first trimester of pregnancy.

Zotrix uses

Zotrix is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

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