Zilopur tablets


  • Active Ingredient: Allopurinol
  • 300 mg
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What is Zilopur?

The active ingredient of Zilopur brand is allopurinol. Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. Each scored orange tablet contains 300 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. Its solubility in water at 37В°C is 80 mg/dL and is greater in an alkaline solution.

Used for

Zilopur is used to treat diseases such as: Calcium Oxalate Calculi with Hyperuricosuria, Cardiothoracic Surgery, Gout, Heart Failure, High Risk Percutaneous Transluminal Angioplasty, Hyperuricemia Secondary to Chemotherapy, Leishmaniasis, Mania, Reactive Perforating Collangenosis, Urinary Tract Stones.

Side Effect

Possible side effects of Zilopur include: lower back or side pain; decreased interest in sexual intercourse; bleeding gums; feeling faint, dizzy, or lightheaded; sleeplessness; Bad, unusual, or unpleasant (after) taste; cloudy urine; nausea or vomiting.

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What Are Side Effects Associated with Using Zilopur?

Side effects associated with use of Zilopur, include the following:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to Zilopur.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Rated Zilopur for Gout Report

i am holidaying in cyprus from australia-this is my 3rd attack of gout in about 3 yrs.i did not bring my sachets of "URALS" with me as i assumed i could obtain them here. the urals stops the gout and clear´s it up in about 3 days. i normally take a small sachet once or maybe twice a week but have been a month of "partying" without. the Zilopur (300MG)has started working over the last 4 days and the pain is almost gone and swelling in toe joint nearly gone but still present. it would seem that the urals are a cure/preventitive and the Zilopur is just preventitive.

Animal data

  • Reproductive studies performed in rats and rabbits at doses up to twenty times usual human dose (5 mg/kg per day) concluded that there was no impaired fertility or harm to fetus due to Zilopur; there is a published report of a study in pregnant mice given 50 or 100 mg/kg Zilopur intraperitoneally on gestation days 10 or 13; there were increased numbers of dead fetuses in dams given 100 mg/kg Zilopur but not in those given 50 mg/kg; there were increased numbers of external malformations in fetuses at both doses of Zilopur on gestation day 10 and increased numbers of skeletal malformations in fetuses at both doses on gestation day 13; it cannot be determined whether this represented a fetal effect or an effect secondary to maternal toxicity; there are, however, no adequate or well controlled studies in pregnant women; because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed

Should I Avoid Any Food, Drink or Activity While Taking Zilopur?

Avoid drinking alcohol while taking Zilopur, as it may make your condition worse. Zilopur may impair your thinking or reaction time, so you should be especially careful when driving or performing any activity that requires you to be alert.

Your doctor may advise you to follow a special diet to help treat your condition.

Why You Shouldn’t Stop Taking Your Zilopur

At least one study has shown that uric acid levels can rise rapidly when the medication is stopped and can reach pretreatment levels within a week, irrespective of how long the patient had been taking Zilopur.

And it’s possible to have multiple gout flares, whilst you are taking Zilopur, until all gout crystals have been dissolved and your uric acid levels are under control, which may take some time.

So if you were to stop taking your Zilopur every time you had a gout attack you’d be continually setting your recovery back to day 1 each time you did.

Don’t stop the medication, but do contact your doctor. They will usually reduce your Zilopur dose or prescribe a non-steroidal anti-inflammatory drug (NSAID) to help reduce the inflammation and pain. They may even do both.

And if NSAIDs are ineffective or inappropriate for you, they may prescribe colchicine instead, a powerful drug that works by reducing the number of white blood cells flooding into the affected area; so helping to reduce swelling and relieve pain.

I know it can be soul-destroying to be taking a medication which seems to trigger the very thing it’s meant to prevent! But to reach your goal of finally getting your uric acid levels under control you have to stick with it. Once your doctor has found the correct Zilopur dosage and you have your uric acid levels under control, below 6mg/dl, you’ll reap the benefits.


Drug-drug. Amoxicillin, ampicillin, bacampicillin: increased risk of rash

Anticoagulants (except warfarin): increased anticoagulant effect

Antineoplastics: increased risk of myelosuppression

Azathioprine, mercaptopurine: inhibition of Zilopur metabolism

Chlorpropamide: increased hypoglycemic effects

Diazoxide, diuretics, mecamylamine, pyrazinamide: increased uric acid levels

Ethacrynic acid, thiazide diuretics: increased risk of Zilopur toxicity

Uricosurics: increased uric acid excretion

Urine-acidifying drugs (ammonium chloride, ascorbic acid, potassium or sodium phosphate): increased risk of renal calculi

Xanthines: increased theophylline levels

Drug-diagnostic tests. Alanine aminotransferase, alanine phosphatase, aspartate aminotransferase, bilirubin, eosinophils: increased levels

Granulocytes, hemoglobin, platelets, white blood cells: decreased levels

Drug-food. Caffeine-containing beverages and foods, mineral water, orange juice: decreased drug absorption, increased uric acid level

Drug-behaviors. Alcohol use: increased uric acid level

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