How should this medicine be used?
Zildem comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. The regular tablet is usually taken three or four times a day. The extended-release capsule and tablet are usually taken one or two times a day. Ask your pharmacist if you should take Zildem with or without food, because instructions may vary with each product. Take Zildem at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Zildem exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the extended-release capsules and tablets whole; do not chew or crush them.
Your doctor will probably start you on a low dose of Zildem and gradually increase your dose, not more than once every 7 to 14 days if you are taking the extended-release tablet or capsule and not more than once every 1 to 2 days if you are taking the regular tablet.
If taken regularly, Zildem may control chest pain, but it does not stop chest pain once it starts. Your doctor may give you a different medication to take when you have chest pain.
Zildem controls high blood pressure and chest pain (angina) but does not cure them. It may take up to 2 weeks before you feel the full benefit of Zildem. Continue to take Zildem even if you feel well. Do not stop taking Zildem without talking to your doctor.
Taking these drugs together can decrease the amount of Zildem in your body. This means that it won’t work as well to treat your high blood pressure or chest pain. These drugs include:
Controlled and uncontrolled domestic studies suggest that concomitant use of Zildem hydrochloride and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. Administration of Zildem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. In vitro, propranolol appears to be displaced from its binding sites by Zildem. If combination therapy is initiated or withdrawn in conjunction with propranolol, an adjustment in the propranolol dose may be warranted (see WARNINGS).
Missed Dose of Zildem
If you miss a dose of Zildem, take it as soon as you remember.
However, if it is almost time for your next dose, skip the missed dose and continue on your regular schedule.
Do not "double up" to make up for a missed one.
How it works
Zildem belongs to a class of drugs called calcium channel blockers. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.
Zildem works by relaxing the blood vessels in your heart and body. This reduces your blood pressure.
This drug also lowers your heart rate and dilates your coronary arteries. This means that your heart doesn’t have to work as hard to pump blood throughout your body. These effects, combined with lowering your blood pressure, help to reduce your chest pain.
Zildem oral capsule doesn’t cause drowsiness. However, it can cause other side effects.
COMMON BRAND(S): Cardizem
GENERIC NAME(S): Zildem Hcl
Zildem is used to prevent chest pain (angina). It may help to increase your ability to exercise and decrease how often you may get angina attacks. Zildem is called a calcium channel blocker. It works by relaxing blood vessels in the body and heart and lowers the heart rate. Blood can flow more easily and your heart works less hard to pump blood.