Table 1: Adult Recommended Dosage Regimen for Prevention of Nausea and Vomiting
Indication Dosage Regimen Highly Emetogenic Cancer Chemotherapy A single 24 mg dose administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin greater than or equal to 50 mg/m 2 Moderately Emetogenic Cancer Chemotherapy 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8 mg dose 8 hours after the first dose.
Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy. Radiotherapy For total body irradiation: 8 mg administered 1 to 2 hours before each fraction of radiotherapy each day.
For single high-dose fraction radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8 mg doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy.
For daily fractionated radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8 mg doses every 8 hours after the first dose for each day radiotherapy is given. Postoperative 16 mg administered 1 hour before induction of anesthesia.
Table 2: Pediatric Recommended Dosage Regimen for Prevention of Nausea and Vomiting
Zemitron may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Adult Dose for Nausea/Vomiting – Postoperative
- Use: Prevention of postoperative nausea and vomiting
- Recommended dose: 16 mg orally 1 hour before the induction of anesthesia
- Recommended dose: 4 mg IV (undiluted) immediately before induction of anesthesia or postoperatively (nausea and/or vomiting within 2 hours after surgery)
- Alternative route: 4 mg IM (undiluted)
Generic Name: Zemitron (Oral route, Oromucosal route)
Medically reviewed by Drugs.com. Last updated on Jan 7, 2019.
How to use Zemitron suppositories
- Remove the suppository from the wrapping.
- You may find that inserting the suppository is easier if you squat or bend forward.
- Using a finger, gently push the suppository into your back passage (rectum).
- Remove your finger and then remain still for a little while to help you hold the suppository in place.
- Then, wash your hands.
Why it's used
Zemitron orally disintegrating tablet is used to prevent nausea and vomiting caused by certain medical treatments. These treatments include:
Dosage for prevention of nausea and vomiting caused by chemotherapy
Adult dosage (ages 18–64 years)
- Typical dosage for chemotherapy that’s highly likely to cause nausea and vomiting: A single 24-mg dose given 30 minutes before chemotherapy.
- Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 8 mg, 30 minutes before chemotherapy. Eight hours later, you can take another 8 mg. For 1–2 days after chemotherapy, you can take 8 mg twice per day.
Child dosage (ages 12–17 years)
- Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 8 mg given 30 minutes before chemotherapy. Four and eight hours after the first dose, your child can take another 8 mg. For 1–2 days after chemotherapy, they can take 8 mg three times per day.
Child dosage (ages 4–11 years)
- Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 4 mg given 30 minutes before chemotherapy. Four and eight hours after the first dose, your child can take another 4 mg. For 1–2 days after chemotherapy, your child can take 4 mg, three times per day.
Child dosage (ages 0–3 years)
It has not been confirmed that Zemitron is safe and effective for use in children younger than 4 years. It should not be used in children of this age range.
Senior dosage (ages 65 years and older)
The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.
Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.
Zemitron (Zofran) is a prescription medication that can be used for prevention or treatment of nausea and vomiting. Zofran is often prescribed every 8 hours as needed for a maximum of 24 mg per day.
Helen Allen, Reviewed by Dr John Cox | Last edited 28 Dec 2016 | Certified by The Information Standard
Zemitron is an anti-sickness medicine.
It will start to work within 1-2 hours.
The most common side-effects are a headache, constipation, and feeling flushed.
What Other Drugs Interact with Zemitron?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Severe Interactions of Zemitron include:
Zemitron has serious interactions with at least 119 different drugs.
Zemitron has moderate interactions with at least 53 different drugs.
Zemitron has minor interactions with at least 28 different drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
Before taking Zemitron
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Zemitron it is important that your doctor knows:
- If you are pregnant or breastfeeding.
- If you have any problems with the way your liver works.
- If you have been told you have an irregular heartbeat.
- If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zemitron only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 13.01.
Warnings for people with certain health conditions
For people with risk factors for heart arrhythmias: If you have conditions such as heart failure or congenital long QT syndrome, this drug may increase your risk of arrhythmias. Ask your doctor if you have risk factors for arrhythmias.
For people with phenylketonuria: The Zemitron orally disintegrating tablet contains phenylalanine. This amino acid can cause dangerous effects in people with a condition called phenylketonuria. Don’t take the orally disintegrating tablet if you have phenylketonuria.
Getting the most from your treatment
- Zemitron should start to work within an hour or so. If you are taking tablets or liquid medicine and you are sick within one hour of taking a dose, you should take the same dose again. This does not apply, however, if you are using suppositories or if you have been given an injection, as being sick will not prevent these from being absorbed by your body.
- Even if you do not feel like eating or drinking, try to sip water regularly to prevent you from becoming lacking in fluids (dehydrated). Also, rather than trying to eat three main meals a day, try eating small, simple but nourishing snacks, every few hours.
Warnings for other groups
For pregnant women: There haven’t been enough studies done in humans to be certain how Zemitron might affect a fetus when the mother takes it. Research in animals has not shown a risk to the fetus. However, animal studies do not always predict the way humans would respond.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used in pregnancy if clearly needed.
For women who are breastfeeding: Zemitron may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.
For children: This medication has not been studied in children younger than 4 years. It should not be used in children of this age range.
All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose