Zapine tablets


  • Active Ingredient: Clozapine
  • 100 mg, 50 mg, 25 mg
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What is Zapine?

The active ingredient of Zapine brand is clozapine. Clozapine is an antipsychotic medicine works by changing the actions of chemicals in the brain.

Used for

Zapine is used to treat diseases such as: Borderline Personality Disorder, Paranoid Disorder, Schizophrenia.

Side Effect

Possible side effects of Zapine include: confusion; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; bloating; swelling of the salivary glands; change in appetite; halos around lights.

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Pregnancy and Zapine

Zapine is an FDA Pregnancy Category B drug, which means it's not likely to harm an unborn baby.

You should tell your doctor if you are pregnant or plan to become pregnant while taking Zapine.

Taking antipsychotic drugs during the last three months of pregnancy may cause withdrawal symptoms in newborns.

However, you may experience withdrawal symptoms if you stop taking the medicine during pregnancy.

Talk to your doctor about the risks and benefits of taking Zapine while pregnant.

The medicine can pass into breast milk and may harm a breastfeeding baby. You shouldn't breastfeed while taking Zapine.

Common Side Effects of Zapine

You should tell your doctor if any of the following side effects become severe or don't go away:

  • Dizziness
  • Drowsiness
  • Constipation
  • Increased saliva
  • Dry mouth
  • Restlessness
  • Weight gain
  • Headache


Pharmacologic class: Dibenzodiazepine derivative

Therapeutic class: Antipsychotic agent

Pregnancy risk category B

Can Zapine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Your doctor will discuss the risks of the treatment with you before you start taking Zapine. In particular, Zapine can cause heart problems and blood disorders. You will be given regular check-up appointments so that your doctor can monitor you for any evidence of these.

The table below contains some of the most common unwanted effects associated with Zapine. You will find a full list in the manufacturer's information leaflet supplied with your medicine.

Zapine, also sold under the brand name Clozaril, is an older (i.e. “typical”) antipsychotic medication prescribed to treat neuropsychiatric conditions such as schizophrenia and schizoaffective disorder. Although many people find Zapine to be highly effective for reducing symptoms of their psychiatric disorders, other individuals may find the drug to be intolerable or lacking in efficacy. Any person who doesn’t respond well to Zapine might end up discontinuing treatment, yet when treatment is over, Zapine withdrawal symptoms typically occur.

Table of Contents

Generic Name: Zapine

Pill with imprint CLOZARIL 100 is Yellow, Round and has been identified as Clozaril 100 mg. It is supplied by Novartis Pharmaceuticals.

Clozaril is used in the treatment of schizophrenia and belongs to the drug class atypical antipsychotics. There is no proven risk in humans during pregnancy. Clozaril 100 mg is not a controlled substance under the Controlled Substances Act (CSA).

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you miss taking Zapine for more than 2 days, you should call your doctor before taking any more medication. Your doctor may want to restart your medication at a lower dose.

Information on Zapine

Zapine (marketed as Clozaril, Fazaclo ODT, Versacloz and generics) is an antipsychotic medicine used to treat schizophrenia in patients whose symptoms are not controlled with standard antipsychotic drugs. Zapine is also used in patients with recurrent suicidal behavior associated with schizophrenia or schizoaffective disorder.

While Zapine is beneficial for some patients, there are risks associated with this drug. Specifically, Zapine can decrease the number of neutrophils, a type of white blood cell, that function in the body to fight off infections. When neutrophils are significantly decreased, severe neutropenia may result and the body may become prone to infections. For this reason, patients taking Zapine need to have their absolute neutrophil count (ANC) monitored on a regular basis. This monitoring requirement serves as the basis for the Zapine Risk Evaluation and Mitigation Strategy (REMS).


  • Available only through a restricted program called the Zapine REMS
  • Severe neutropenia, defined as an absolute neutrophil count (ANC) less than 500/mm³, has been reported
  • Severe neutropenia can lead to serious infection and death
  • Prior to initiating treatment, a baseline ANC must be 1500/mm³ or greater for the general population and 1000/mm³ or greater for patients with documented benign ethnic neutropenia
  • Regularly monitor ANC during treatment
  • Advise patients to immediately report symptoms consistent with severe neutropenia or infection (e.g., fever, weakness, lethargy, sore throat)

  • Caution with history of seizure or other factors predisposing to seizure
  • Risk is dose-related

Myocarditis, Cardiomyopathy, and Mitral Valve Incompetence

  • Fatal myocarditis and cardiomyopathy reported; discontinue and obtain cardiac evaluation if suspected
  • Measuring brainNP levels may offer a means of monitoring to detect early, asymptomatic myocarditis
  • Do not re-challenge patients with history of Zapine-associated myocarditis or cardiomyopathy

  • Dizziness upon standing (orthostatic hypotension), slow heart rate (bradycardia), fainting (syncope), and cardiac arrest may occur
  • Risk is highest during initial titration period, particularly with rapid dose escalation
  • May occur with the first dose, and with doses as low as 12.5 mg/day
  • Caution with history of cardiovascular or cerebrovascular disease or conditions predisposing to low blood pressure (hypotension)

Increased mortality in elderly with dementia-related psychosis

  • Not approved for dementia-related psychosis; patients with dementia-related psychosis who are treated with antipsychotic drugs are at increased risk of death, as shown in short-term controlled trials; deaths in these trials appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature

This medication contains Zapine. Do not take Clozaril, FazaClo ODT, or Versacloz if you are allergic to Zapine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

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