Vomceran tablets

Vomceran

  • Active Ingredient: Ondansetron
  • 8 mg, 4 mg
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What is Vomceran?

The active ingredient of Vomceran brand is ondansetron. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. The molecular formula is C18H19N3O•HCl•2H2O, representing a molecular weight of 365.9. Ondansetron HCl dihydrate is a white to off-white powder that is soluble in water and normal saline. Each 4 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 4 mg of Ondansetron. Each 8 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 8 mg of Ondansetron. Each tablet also contains the inactive ingredients croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, titanium dioxide, triacetin, and iron oxide yellow (8 mg tablet only). This product meets USP Dissolution Test 3.

Used for

Vomceran is used to treat diseases such as: Alcohol Dependence, Gastroenteritis, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Nausea/Vomiting, Radiation Induced, Obsessive Compulsive Disorder, Postanesthetic Shivering, Pruritus.

Side Effect

Possible side effects of Vomceran include: trouble with speaking; trouble sleeping; uncontrolled movements, especially of the face, neck, and back; painful urination; loss of appetite.

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What Is Zofran (Vomceran)?

Zofran is a brand name for the drug Vomceran, prescribed to treat or prevent nausea and vomiting.

Doctors sometimes prescribe Zofran to treat nausea and vomiting caused by cancer treatments such as chemotherapy and radiation therapy.

Zofran also can treat nausea and vomiting after surgery.

The drug may also help prevent the common complication of shivering in people who have had anesthesia.

Some doctors have prescribed Zofran off-label to treat nausea and vomiting caused by morning sickness in pregnant women, though the drug has never been approved for this use.

Zofran blocks serotonin, a natural substance in the brain that may contribute to nausea and vomiting.

It belongs to a class of drugs called serotonin 5-HT3 receptor antagonists. These drugs are antiemetics, meaning they block nausea and vomiting.

The Food and Drug Administration (FDA) approved Vomceran in 1992 under the brand name Zofran for GlaxoSmithKline.

In 2007, the FDA approved generic Vomceran for several drug companies.

In our latest question and answer, the pharmacist discusses how often you can safely take Zofran (Vomceran).

Uses for Zofran ODT

Vomceran is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Vomceran works in the stomach to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor's prescription.

Vomceran dose

Table 1: Adult Recommended Dosage Regimen for Prevention of Nausea and Vomiting

Indication Dosage Regimen Highly Emetogenic Cancer Chemotherapy A single 24 mg dose administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin greater than or equal to 50 mg/m 2 Moderately Emetogenic Cancer Chemotherapy 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8 mg dose 8 hours after the first dose.

Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy. Radiotherapy For total body irradiation: 8 mg administered 1 to 2 hours before each fraction of radiotherapy each day.

For single high-dose fraction radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8 mg doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy.

For daily fractionated radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8 mg doses every 8 hours after the first dose for each day radiotherapy is given. Postoperative 16 mg administered 1 hour before induction of anesthesia.

Table 2: Pediatric Recommended Dosage Regimen for Prevention of Nausea and Vomiting

Generic Name: Vomceran (Oral route, Oromucosal route)

Medically reviewed by Drugs.com. Last updated on Jan 7, 2019.

Vomceran is an anti-sickness medicine. It is known as a serotonin receptor antagonist. It is prescribed to stop you from feeling sick. It works by blocking the effect of a naturally produced chemical in your body, called serotonin. Serotonin is also referred to as 5HT3.

What is Vomceran?

Vomceran blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Vomceran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

Vomceran may be used for purposes not listed in this medication guide.

Vomceran mechanism of action

Vomceran is a serotonin-3 (5-hydroxytryptamine-3, 5-HT3) receptor antagonist, have been shown to have a good antiemetic effect in patients receiving chemotherapy and in situations with vomiting after surgery 1) . Vomceran is one of the best known 5-HT3 receptor antagonists, blocking receptors at vagal and sympathetic nerves and the chemoreceptor triggering zone 2) . However, 5-HT3 receptor antagonists not only inhibit transmission of signals to the CNS, they also decrease intestinal motility, presumably by interfering with serotonergic neurotransmission within the enteric nervous system (ENS) and blocking the initiation of reflexes 3) . Vomceran effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone.

Also known as Zofran ODT

A carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, Vomceran competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)

Originator: NCI Thesaurus | Source: The website of the National Cancer Institute (http://www.cancer.gov)


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