Vertab

Vertab

  • Active Ingredient: Dimenhydrinate
  • 50 mg
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What is Vertab?

The active ingredient of Vertab brand is dimenhydrinate. Dimenhydrinate is an antihistamine that reduces the effects of natural chemical histamine in the body.

Used for

Vertab is used to treat diseases such as: Insomnia, Motion Sickness, Nausea/Vomiting.

Side Effect

Possible side effects of Vertab include: ; ; ; ; ; ; ; .

How to Buy Vertab online?

To buy Vertab online - simply click on the "Buy Now" button from the top and follow along with our shop. Order and payment takes a couple of minutes, and all steps are evident. We do not take a medical prescription plus also we have many procedures of payment. With all the details of fast delivery and confidentiality, then you can read on the applicable pages on the hyperlinks in the navigation menu.

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PRODUCT INFORMATION

REPRESENTATIVE TRADE NAMES

Vertab – Generic, Dramamine®

Product labeling at DailyMed, National Library of Medicine, NIH

How should I take Vertab?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

For best results, take Vertab 30 to 60 minutes before traveling or before any activity that may trigger motion sickness.

You may take Vertab with or without food.

The chewable tablet must be chewed before you swallow it.

If you need surgery, tell the surgeon ahead of time if you have taken Vertab in the past few days.

Store at room temperature away from moisture and heat.

Other uses for this medicine

Vertab is also sometimes used to treat Meniere's disease (condition of the inner ear which causes extreme dizziness, loss of balance, ringing in the ears, and hearing loss) and other inner ear problems. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Contraindications

Documented hypersensitivity to Vertab or diphenhydramine

Lower respiratory disease, eg, asthma (controversial)

Preemies and neonates

Vertab

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What other drugs will affect Vertab?

Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking Vertab with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

What other information should I know?

Ask your pharmacist any questions you have about Vertab.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Some side effects can be serious. If you experience the following symptom, call your doctor immediately:

  • fast, pounding, or irregular heartbeat

Vertab may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Further information

  • Your pharmacist has more information about Vertab written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 4.01.

Generic Name: Vertab

Pill with imprint DRAMAMINE is White, Round and has been identified as Dramamine 50 mg. It is supplied by McNeil Consumer.

Dramamine is used in the treatment of nausea/vomiting; motion sickness and belongs to the drug class anticholinergic antiemetics. There is no proven risk in humans during pregnancy. Dramamine 50 mg is not a controlled substance under the Controlled Substances Act (CSA).

What is Vertab?

Vertab is an antihistamine that reduces the effects of natural chemical histamine in the body.

Vertab is used to treat or prevent nausea, vomiting, and dizziness associated with motion sickness.

Vertab may also be used for purposes not listed in this medication guide.

IV Incompatibilities

Additive: aminophylline (at 1g/L aminophylline and 500 mg/L Vertab; may be compatible at lower conc), ammonium chloride(?), hydrocortisone (at 500 mg hydrocortisone and 500 mg Vertab; may be compatible at lower conc), thiopental

Syringe: butorphanol, chlorpromazine, glycopyrrolate, hydroxyzine, iodipamide, midazolam, nalbuphine, papaveretum, pentobarbital, prochlorperazine, promazine, promethazine, thiopental

Vertab and Diphenhydramine

Vertab is a theoclate salt composed of diphenhydramine, an ethanolamine derivative, and 8-chlorotheophylline, a chlorinated theophylline derivative, in a 1 : 1 ratio. Vertab must be metabolized into its active ingredient diphenhydramine to attain antiemetic efficacy. Therefore Vertab has a slower onset of action and is administered as a 60-mg dose to match the potency of 30 mg diphenhydramine. 59 Diphenhydramine itself undergoes N-demethylation to its principal metabolite monodesmethyldiphenhydramine (DMDP) in the liver. 62 Oral diphenhydramine bioavailability ranges from 43% to 72%, probably owing to first-pass metabolism, with peak plasma concentrations of approximately 64 ng/mL after approximately 2.5 hours. 62,63 Plasma concentration of diphenhydramine covaries with that of DMDP ( Fig. 34.10A ). The observed plasma half-life of oral Vertab is 3 to 9.3 hours, and the elimination half-lives after intravenous and oral administration are 8.4 and 9.2 hours, respectively, for diphenhydramine and 9.3 and 7.3 hours, respectively, for DMDP (see Fig. 34.10B ). 64 The observed metabolite area under the curve (AUC) after oral administration (218 hr.ng/mL) is significantly larger than after intravenous administration (145 hr-ng/mL). 64 Sedative and performance-impairing side effects are typically associated with diphenhydramine doses greater than or equal to 50 mg and differ from placebo only within the first 3 hours. 62,65 Although there is a positive correlation between plasma concentration and sedative effects, there is also wide variation among individuals in the severity and persistence of these effects. 65

What happens if I miss a dose?

Since Vertab is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Introduction

Vertab is a first generation antihistamine that is used for treatment or prevention of motion sickness or symptoms of nausea and dizziness. Vertab has not been linked to instances of clinically apparent acute liver injury.

Vertab and Diphenhydramine

Vertab is a theoclate salt composed of diphenhydramine, an ethanolamine derivative, and 8-chlorotheophylline, a chlorinated theophylline derivative, in a 1:1 ratio. Vertab must be metabolized into its active ingredient diphenhydramine to attain antiemetic efficacy. Therefore Vertab has a slower onset of action, and is administered as a 60-mg dose to match the potency of 30-mg diphenhydramine. 59 Diphenhydramine itself undergoes N-demethylation to its principal metabolite monodesmethyldiphenhydramine (DMDP) in the liver. 62 Oral diphenhydramine bioavailability ranges from 43% to 72%, probably due to first-pass metabolism, with peak plasma concentrations of approximately 64 ng/mL after approximately 2.5 hours. 62,63 Plasma concentration of diphenhydramine covaries with that of DMDP ( Figure 29-10, A ). The observed plasma half-life of oral Vertab is 3 to 9.3 hours, and the elimination half-lives after intravenous and oral administration are 8.4 and 9.2 hours, respectively, for diphenhydramine, and 9.3 and 7.3 hours, respectively, for DMDP (see Figure 29-10, B ). 64 The observed metabolite area under the curve (AUC) after oral administration (218 hr-ng/mL) is significantly larger than after intravenous administration (145 hr-ng/mL). 64 Sedative and performance-impairing side effects are typically associated with diphenhydramine doses greater than or equal to 50 mg, and differ from placebo only within the first 3 hours. 62,65 While there is a positive correlation between plasma concentration and sedative effects, there is also wide variation between individuals in the severity and persistence of these effects. 65


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