Uricnol tablets

Uricnol

  • Active Ingredient: Allopurinol
  • 300 mg
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What is Uricnol?

The active ingredient of Uricnol brand is allopurinol. Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. Each scored orange tablet contains 300 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. Its solubility in water at 37В°C is 80 mg/dL and is greater in an alkaline solution.

Used for

Uricnol is used to treat diseases such as: Calcium Oxalate Calculi with Hyperuricosuria, Cardiothoracic Surgery, Gout, Heart Failure, High Risk Percutaneous Transluminal Angioplasty, Hyperuricemia Secondary to Chemotherapy, Leishmaniasis, Mania, Reactive Perforating Collangenosis, Urinary Tract Stones.

Side Effect

Possible side effects of Uricnol include: pinpoint red or purple spots on the skin; thirst; bruising; bloody or black, tarry stools; slow or irregular heartbeat; Abdominal or stomach pain.

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Forms and strengths

Generic: Uricnol

  • Form: oral tablet
  • Strengths: 100 mg, 300 mg

Brand: Zyloprim

  • Form: oral tablet
  • Strengths: 100 mg, 300 mg

Brand: Lopurin

  • Form: oral tablet
  • Strengths: 100 mg, 300 mg

What Are Side Effects Associated with Using Uricnol?

Side effects associated with use of Uricnol, include the following:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Background

Uricnol (al' oh pure' i nol) is an analog of hypoxanthine and a potent inhibitor of the enzyme xanthine oxidase that is responsible for converting hypoxanthine to xanthine and xanthine to uric acid in the breakdown pathway of purines. Uricnol lowers serum and tissue uric acid levels and has potent activity against gout, largely in preventing rather than treating acute attacks of gout. Uricnol was approved for use in the United States in 1963 and is still widely used. Current indications include therapy and prevention of gout, uric acid nephropathy, and the hyperuricemia caused by malignancy and anticancer therapy. It is not recommended for treatment of asymptomatic hyperuricemia. Uricnol is available in multiple generic forms and under the brand name of Zyloprim or Aloprim in tablets of 100 and 300 mg. Intravenous formulations are also available. The recommended initial dose for therapy of gout is 100 mg daily, with increases of 100 mg in daily dose weekly until uric acid levels fall to 6 mg/dL or below, but not to exceed 800 mg daily. The average daily dose in therapy of gout is 300 mg. Common side effects include skin rash and hypersensitivity reactions.

Introduction

Uricnol is a xanthine oxidase inhibitor and a widely used medication for gout. Uricnol is a rare but well known cause of acute liver injury that has features of a hypersensitivity reaction and can be severe and even fatal.

Should I Avoid Any Food, Drink or Activity While Taking Uricnol?

Avoid drinking alcohol while taking Uricnol, as it may make your condition worse. Uricnol may impair your thinking or reaction time, so you should be especially careful when driving or performing any activity that requires you to be alert.

Your doctor may advise you to follow a special diet to help treat your condition.

Lactation

Uricnol and oxipurinol have been found in milk of mother who was receiving drug; since effect of Uricnol on nursing infant is unknown, exercise caution when therapy is administered to nursing woman

Q: My wife is 71, has severe pseudogout, and has developed intractable bilateral wrist pain. She takes NSAIDs and low-dose prednisone (10 mg daily). Higher doses of 40 to 60 mg daily have caused a mildly elevated blood sugar of 20 to 130mg/dl. Is it possible that Uricnol could help the excretion of the calcium pyrophosphate from her joints as it does uric acid in gout? Also, she is reluctant to resume higher doses of prednisone during severe flare-ups because she and her physician believe it will cause her low-grade diabetes to worsen. What do you recommend?

A: Pseudogout is a form of arthritis that is brought on by deposits of calcium crystals in the joints. This causes pain, swelling and inflammation of the joint, and sometimes may be accompanied by fever. It is not always clear why people develop pseudogout. Risk factors may include: age, joint injury, and genetic disorders- familial chondrocalcinosis and hemochromatosis. Some of the treatments that may be used for pseudogout include: Non-steroidal anti-inflammatories (NSAIDs), oral steroids, injectable steroids, and also colchicine. Colchicine may be used to prevent attacks of pseudogout. However it does not appear that colchicine is FDA-approved for this indication. Uricnol is in a group of medications called xanthine oxidase inhibitors. Uricnol is used to prevent the buildup of uric acid crystals that lead to painful gout and kidney stones. Uricnol works by inhibiting the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid. There was no mention of Uricnol being used in the treatment of pseudogout or preventing buildup of calcium crystals. For more specific information, consult with your doctor for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD

Allergy warning

Uricnol can cause a severe allergic reaction. Symptoms can include:

  • itchy hives (raised bumps on your skin)
  • red or purple-colored spots on your skin
  • scaly skin
  • fever
  • chills
  • trouble breathing
  • swelling of your face or throat

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Uricnol Dosage

The typical adult dose of Uricnol for gout is:

Initial Dose : 100 to 200 milligrams (mg), once a day.

Maintenance Dose : 200 to 300 mg orally, once a day, for mild gout or 400 to 600 mg a day in divided doses for moderately severe gout.

You should take each dose of Uricnol with a full glass of water. To reduce the risk of kidney stones forming, you should drink eight to 10 full glasses of fluid every day.

How should I take Uricnol?

Take Uricnol exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Take each dose with a full glass of water. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise.

Take with food if Uricnol upsets your stomach.

You may have gout attacks more often when you first start taking Uricnol. Your doctor may recommend other gout medication to take at this time. Keep using your medication as directed and tell your doctor if your symptoms do not improve after 6 weeks of treatment.

You may need to follow a special diet while using Uricnol. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.

Store at room temperature away from moisture and heat.

Why it's used

Uricnol is used to decrease uric acid levels in the blood and urine of people with high uric acid levels. High uric acid levels may be caused by the following:

  • gout
  • kidney stones, kidney damage, or treatment with dialysis
  • cancer chemotherapy
  • psoriasis
  • use of diuretics (water pills)
  • a diet high in soft drinks, beef, steak, salami, or beer

DESCRIPTION

ZYLOPRIM (Uricnol) has the following structural formula:

ZYLOPRIM (Uricnol) is known chemically as 1,5-dihydro-4H-pyrazolo pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg Uricnol and the inactive ingredients lactose, magnesium stearate, potato starch, and povidone. Each scored peach tablet contains 300 mg Uricnol and the inactive ingredients corn starch, FD&C Yellow No. 6 Lake, lactose, magnesium stearate, and povidone. Its solubility in water at 37°C is 80.0 mg/dL and is greater in an alkaline solution.

What other drugs will affect Uricnol?

Tell your doctor about all your other medicines, especially:

a blood thinner such as warfarin, Coumadin, Jantoven; or

a diuretic or "water pill".

This list is not complete. Other drugs may interact with Uricnol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What special dietary instructions should I follow?

Drink at least eight glasses of water or other fluids each day while taking Uricnol unless directed to do otherwise by your doctor.


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