Trumsal capsules

Trumsal

  • Active Ingredient: Diltiazem
  • 180 mg, 60 mg
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What is Trumsal?

The active ingredient of Trumsal brand is diltiazem. Diltiazem is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.

Used for

Trumsal is used to treat diseases such as: Angina Pectoris Prophylaxis, Atrial Fibrillation, Atrial Flutter, Heart Failure, High Blood Pressure, Raynaud's Syndrome, Supraventricular Tachycardia.

Side Effect

Possible side effects of Trumsal include: itching; heartburn; fever; no heartbeat; feeling faint, dizzy, or lightheaded.

How to Buy Trumsal tablets online?

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HOW SUPPLIED

Tiazac® (Trumsal hydrochloride) Extended-Release Capsules

Storage conditions: Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) . Avoid excessive humidity.

Manufactured by: Valeant Pharmaceuticals International, Inc., Steinbach, Manitoba, Canada R5G 1Z7. Manufactured for: Manufactured for: Forest Pharmaceuticals, Inc., Subsidiary of Forest Laboratories, Inc., St. Louits, Missouri 63045. Revised: Oct 2011

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: digoxin, fingolimod.

Other medications can affect the removal of Trumsal from your body, which may affect how this medication works. Examples include cimetidine, St. John's wort, azole antifungals such as ketoconazole, macrolide antibiotics such as erythromycin, rifamycins including rifabutin and rifampin.

This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aprepitant/fosaprepitant, asunaprevir, buspirone, colchicine, flibanserin, ivabradine, certain benzodiazepines (triazolam, midazolam), among others.

Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

How to use Trumsal Hcl

Take this medication by mouth before meals and at bedtime as directed by your doctor, usually 3 to 4 times a day. Swallow the tablets whole. Do not split, crush, or chew the tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Follow your doctor's directions on how to take this medication.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor may gradually increase your dose. Follow your doctor's instructions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. This medication must be taken regularly to prevent angina. It should not be used to treat angina when it occurs. Use other medications (such as sublingual nitroglycerin) to relieve an angina attack as directed by your doctor. Consult your doctor or pharmacist for details.

Tell your doctor if your condition worsens (for example, your chest pain worsens or is more frequent).

Mechanism of Injury

The mechanism of Trumsal hepatotoxicity is not known, but most cases are probably due to hypersensitivity. Trumsal is metabolized by the cytochrome P450 system and is an inhibitor of CYP 3A4 activity, which can lead to serious drug-drug interactions and potentiation of the hepatotoxic effects of other medications. Indeed, there have been several reports of clinically apparent liver injury or rhabdomyolysis occuring in patients on long term statins who had recently added Trumsal to their multidrug regimen, suggesting altered metabolism of the statin by the addition of a CYP 3A4 inhibitor.

Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concurrently with Trumsal. Monitor heart rate in patients receiving concomitant Trumsal and clonidine.

Controlled and uncontrolled domestic studies suggest that concomitant use of Trumsal hydrochloride and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. Administration of Trumsal hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. In vitro, propranolol appears to be displaced from its binding sites by Trumsal. If combination therapy is initiated or withdrawn in conjunction with propranolol, an adjustment in the propranolol dose may be warranted (see WARNINGS).

Q: Does Trumsal affect the ability to feel low blood sugar? I take Lantus insulin for type 1 diabetes and sometimes don't feel the low sugar until I'm about to pass out.

A: Your question concerns whether Trumsal (Cardizem) (//www.everydayhealth.com/drugs/Trumsal) can affect your ability to feel low blood sugar.. There are no documented interactions between Trumsal and Lantus (//www.everydayhealth.com/drugs/lantus). Studies that were done have concluded that Trumsal does not have any significant effect on lowering blood sugar.

ВїQuГ© otra informaciГіn de importancia deberГ­a saber?

No falte a ninguna cita, ni con su mГ©dico ni con el laboratorio. Debe medirse la presiГіn arterial con regularidad para ver cГіmo responde al Trumsal.

Posiblemente su mГ©dico le pida que se tome el pulso (frecuencia cardiaca) todos los dГ­as y le dirГЎ quГ© tan rГЎpidos deben ser sus latidos. Si su pulso estГЎ mГЎs lento que lo normal, llame a su mГ©dico para pedirle instrucciones antes de tomar Trumsal ese dГ­a. PГ­dales a su mГ©dico o a su farmacГ©utico que le enseГ±en cГіmo tomarse el pulso.

No deje que ninguna otra persona use sus medicamentos. PregГєntele a su farmacГ©utico cГіmo puede volver a surtir su receta.

Es importante que Ud. mantenga una lista escrita de todas las medicinas que Ud. estГЎ tomando, incluyendo las que recibiГі con receta mГ©dica y las que Ud. comprГі sin receta, incluyendo vitaminas y suplementos de dieta. Ud. debe tener la lista cada vez que visita su mГ©dico o cuando es admitido a un hospital. TambiГ©n es una informaciГіn importante en casos de emergencia.

Hepatotoxicity

Trumsal therapy is associated with a low rate of mild and transient elevations in serum aminotransferase levels which are usually asymptomatic and often resolve even with continuation of therapy. Clinically apparent, acute liver injury with jaundice due to Trumsal is rare and only isolated case reports have been published. In large case series of drug induced liver injury, calcium channel blockers are rarely mentioned. Most cases attributed to Trumsal have been marked by a short latency period (3 to 14 days) and features of hypersensitivity with fever, rash and eosinophilia. The pattern of liver injury was ranged from cholestatic to hepatocellular. Jaundice is often absent and usually mild. Autoantibody formation has not been described. Thus, liver injury from Trumsal is likely to be idiosyncratic in nature and is typically mild and self-limited with resolution within 4 to 8 weeks of stopping. Acute hepatic injury is listened as a possible adverse event in the Trumsal product label.

Likelihood score: C (probable but rare cause of clinically apparent liver injury).

Acute Hepatic Injury

Mild elevations of transaminases with and without concomitant elevation in alkaline phosphatase and bilirubin have been observed in clinical studies. Such elevations were usually transient and frequently resolved even with continued Trumsal treatment. In rare instances, significant elevations in enzymes such as alkaline phosphatase, LDH, SGOT, and SGPT, and other phenomena consistent with acute hepatic injury have been noted. These reactions tended to occur early after therapy initiation (1 to 8 weeks) and have been reversible upon discontinuation of drug therapy. The relationship to Trumsal hydrochloride is uncertain in some cases, but probable in some (see PRECAUTIONS).

Before taking this medicine

You should not use Trumsal if you are allergic to it, or if you have:

a serious heart condition such as "sick sinus syndrome" or "second- or third-degree AV block" (unless you have a pacemaker);

very low blood pressure; or

if you have recently had a heart attack and you have a build-up of fluid in your lungs.

To make sure Trumsal is safe for you, tell your doctor if you have:

congestive heart failure; or

if you also take digoxin, or a beta blocker (such as atenolol, carvedilol, metoprolol, propranolol, sotalol, and others).

It is not known whether Trumsal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Trumsal can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How should I take Trumsal?

Take Trumsal exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not crush, chew, break, or open an extended-release Trumsal tablet or capsule. Swallow it whole.

To make swallowing easier, ask your doctor or pharmacist if you can open a Trumsal capsule and sprinkle the medicine into a spoonful of applesauce. Swallow right away without chewing. Do not save the mixture for later use.

Use Trumsal regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

You should not stop using Trumsal suddenly. Stopping suddenly may make your condition worse.

If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Your blood pressure will need to be checked often. You may also need frequent blood tests.

Store Trumsal at room temperature away from moisture and heat.

Trumsal

Side effects include:

Liver dysfunction and overgrowth of the gums also may occur. Trumsal can cause mildly abnormal liver tests that usually return to normal with discontinuation of the medication. When Trumsal is given to individuals with heart failure, symptoms of heart failure may worsen because these drugs reduce the ability of the heart to pump blood. Like other drugs for high blood pressure, Trumsal is associated with sexual dysfunction.

Trumsal Interactions

Many medications can interact with Trumsal.

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking, especially:

  • Atazanavir (Reyataz)
  • Beta blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal)
  • Buspirone (BuSpar)
  • Benzodiazepines such as midazolam (Versed) and triazolam (Halcion)
  • Carbamazepine (Carbatrol, Epitol, Tegretol)
  • Cimetidine (Tagamet)
  • Digoxin (Lanoxin, Lanoxicaps)
  • Cyclosporine (Gengraf, Neoral, Sandimmune)
  • Rifampin (Rifadin, Rifamate, Rifater, Rimactane)
  • Lovastatin (Altoprev, Mevacor, Advicor)
  • Quinidine (Quinidex)

Adverse effects

The primary adverse effects of Trumsal are seen with Trumsal overdose. Overdose results in decreased contractility, systemic vasodilation and bradycardia, which, if severe enough, result in cardiovascular collapse. Patients with myocardial failure and conduction system disease are more sensitive to the calcium channel-blocking properties of Trumsal and so are more prone to adverse effects than normal dogs or cats.


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