Rison tablets

Rison

  • Active Ingredient: Risperidone
  • 4 mg, 2 mg, 1 mg
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What is Rison?

The active ingredient of Rison brand is risperidone. Risperidone is a antipsychotic medicine. It works by changing the effects of chemicals in the brain. Risperidone USP is a white to slightly beige powder. It is practically insoluble in water, freely soluble in methylene chloride, and soluble in methanol and 0.1 N HCl . Risperidone tablets, USP are for oral administration and available in 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg strengths. Inactive ingredients are lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, hypromellose, titanium dioxide and polyethylene glycol 400. The 0.25 mg, 0.5 mg, 3 mg and 4 mg tablets contain D&C Yellow # 10 aluminum lake. The 0.5 mg and 4 mg tablets also contain FD&C Blue # 2 aluminum lake. The 2 mg tablets contain iron oxide yellow, iron oxide red, and iron oxide black.

Used for

Rison is used to treat diseases such as: Agitation, Anxiety, Asperger Syndrome, Autism, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Depression, Head Injury, Mania, Nightmares, Paranoid Disorder, Post Traumatic Stress Disorder, Schizoaffective Disorder, Schizophrenia, Severe Mood Dysregulation, Social Anxiety Disorder, Tic Disorder.

Side Effect

Possible side effects of Rison include: anxiety; loss of voice; decreased interest in sexual intercourse; weight gain; ear congestion.

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What Are the Most Common and Serious Side Effects of Rison?

Common side effects of Rison (Risperdal) include:

  • Sleepiness
  • Dizziness
  • Nausea or vomiting
  • Diarrhea
  • Constipation
  • Heartburn
  • Dry mouth
  • Increased saliva
  • Increased appetite
  • Weight gain
  • Stomach pain
  • Anxiety
  • Agitation
  • Restlessness
  • More frequent dreaming
  • Trouble sleeping
  • Low sex drive or sexual problems
  • Unusual breast milk production
  • Vision problems
  • Muscle or joint pain
  • Dry or discolored skin
  • Trouble urinating

Serious side effects can also occur while taking Rison. If you have any of these side effects, call your doctor immediately:

  • Fever
  • Muscle stiffness
  • Confusion
  • Fast or irregular pulse
  • Sweating
  • Abnormal movements of your face or body that you cannot control
  • Lightheadedness
  • Seizures
  • Slow movements or shuffling walk
  • Rash
  • Hives
  • Itching
  • Trouble breathing or swallowing
  • Painful erection that lasts for hours

How should this medicine be used?

Rison comes as a tablet, a solution (liquid), and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken once or twice a day with or without food. Take Rison at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Rison exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Use the dropper provided to measure your dose of Rison oral solution. You can take the oral solution with water, orange juice, coffee, or low-fat milk. Do not take the solution with tea or cola.

Do not try to push the orally disintegrating tablet through the foil. Instead, use dry hands to peel back the foil packaging. Immediately take out the tablet and place it on your tongue. The tablet will quickly dissolve and can be swallowed with or without liquid. Do not chew or crush the tablet.

Your doctor will probably start you on a low dose of Rison and gradually increase your dose to allow your body to adjust to the medication.

Rison may help control your symptoms but will not cure your condition. It may take several weeks or longer before you feel the full benefit of Rison. Continue to take Rison even if you feel well. Do not stop taking Rison without talking to your doctor. If you suddenly stop taking Rison, your symptoms may return and your illness may become harder to treat.

How it works

Rison belongs to a class of drugs called atypical antipsychotics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Rison works by affecting the amount of certain chemicals called neurotransmitters that occur naturally in your brain. It’s thought that people with schizophrenia, bipolar disorder, and autism have an imbalance of certain neurotransmitters. This drug may improve this imbalance.

Rison oral tablet may cause drowsiness. It may also cause other side effects.

What is risper >

Rison is an antipsychotic medicine that works by changing the effects of chemicals in the brain.

Rison is used to treat schizophrenia in adults and children who are at least 13 years old.

Rison is also used to treat symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Rison is also used to treat symptoms of irritability in autistic children who are 5 to 16 years old.

Given the primary CNS effects of Rison, caution should be used when RISPERDAL® is taken in combination with other centrally-acting drugs and alcohol.

Risper > Rison is a benzisoxazole derivative approved by the FDA for treatment of schizophrenia in 1994, for short-term treatment of the mixed and manic states of bipolar disorder in 2003, and for treatment of irritability in children with autism in 2006. In 2007 it was approved as a treatment for schizophrenia and bipolar disorder in children. Its pharmacology is characterized by binding affinity for 5-HT 2A receptors that is 20 times that for D2-dopamine receptors. D2-receptor affinity is approximately 50 times, and 5-HT2A receptor affinity approximately 20 times that of clozapine. Rison also has strong affinity for α1-/α2-adrenergic and H1-histamine receptors. Affinity for D1 receptors is low, and it has no affinity at muscarinic receptors. Protein binding is 90%, and it is metabolized by CYP 2D6. D2-receptor occupancy at therapeutic doses is 63% to 89%, which would be expected to be associated with a significant incidence of EPS. 110 The addition of strong serotonergic antagonism, with a 5-HT2 receptor occupancy of 95%, is thought to confer protection against D2 antagonist effects on the nigrostriatal pathway, and the incidence of EPS is low. Nonetheless, unlike other SGAs with relatively lower affinities for D2 receptors that permit dynamic responses to surges in dopamine, Rison is tightly bound and does cause significant hyperprolactinemia. 111,112 It can also cause orthostatic hypotension during early treatment. Rison does not cause prolongation of the QTc and is less arrhythmogenic than other antipsychotics. It carries a boxed warning for increased risk of death in older patients receiving antipsychotics for dementia-related psychosis.


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