Rexapin tablets

Rexapin

  • Active Ingredient: Olanzapine
  • 7.5 mg, 5 mg, 2.5 mg
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What is Rexapin?

The active ingredient of Rexapin brand is olanzapine. Olanzapine is an antipsychotic medication that affects chemicals in the brain.

Used for

Rexapin is used to treat diseases such as: Agitated State, Agitation, Anorexia, Anorexia Nervosa, Asperger Syndrome, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Depression, Insomnia, Major Depressive Disorder, Nausea/Vomiting, Chemotherapy Induced, Obsessive Compulsive Disorder, Paranoid Disorder, Schizoaffective Disorder, Schizophrenia, Tourette's Syndrome.

Side Effect

Possible side effects of Rexapin include: muscle tension or tightness; trouble sleeping; pain in the arms or legs; voice change; nervousness; body aches or pain.

How to Buy Rexapin tablets online?

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Nervous system

Rexapin has occasionally been seen to improve pre-existing tardive cervical dystonia (SEDA-27, 59). However, two patients developed acute dystonias while taking the lowest therapeutic dose of Rexapin (5 mg/day) (95 A ).

Neuroleptic malignant syndrome associated with Rexapin has previously been reported (SEDA-25, 64; SEDA-26, 62; SEDA-27, 60), and two further cases have been reported.

A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum trans-aminase and creatine kinase activities while taking Rexapin and lithium; when both drugs were withdrawn, his fever and rigidity subsided and the biochemical tests returned to normal, without any complications (96 A ).

A 75-year-old man developed typical neuroleptic malignant syndrome while taking Rexapin; he had previously had haloperidol-associated neuroleptic malignant syndrome (97 A ).

The incidence of seizures with Rexapin, which has been estimated at 0.9% of treated patients, is probably comparable to that with other antipsychotic drugs (SEDA-27, 60).

A 32-year-old woman with genetically confirmed Huntington's disease of 6 year's duration, who was treated with increasing doses of Rexapin and responded well to 30 mg/day, had a seizure (98 A ).

The author pointed out that seizures are common in juvenile-onset Huntington's disease but rare in adult-onset Huntington's disease.

How Does Rexapin Work?

Once ingested, Rexapin blocks receptors in the brain to balance the release of neurotransmitters, such as dopamine and serotonin. These neurotransmitters are stored in nerve cells, which travel to different sections of the brain to control the excessive activity associated with schizophrenia and mania.

In this way, Rexapin influences neurotransmitters to manage thinking, mood and behavior. Most people are prescribed Rexapin in small doses. Rexapin can take weeks of regular use to have any effect on anxiety, depression, hallucinations or disturbing thoughts. Of course, the longer the period Rexapin is taken, the more patients become dependent on the drug to function normally.

Rexapin may induce side effects before any of the benefits of the drug are realized. These side effects may include:

  • Weight gain, increased appetite
  • Headache, dizziness, drowsiness, tiredness or restlessness
  • Problems with speech or memory
  • Tremors, shaking, numbness or tingly feelings
  • Changes in personality
  • Dry mouth, or increased salivation

Rexapin is said to have fewer side effects than older antipsychotic drugs. But, at some point, some of these side effects including the increased risk for stroke and diabetes may still outweigh the benefits of taking it. For patients who have taken Rexapin in larger doses for longer periods, the decision to stop taking the medication becomes that much more problematic.

Rexapin versus haloper > There was a different adverse effects profile in a 16-week, double-blind study in 63 out-patients with schizophrenia, who had previously been receiving fluphenazine, when comparing Rexapin ( n = 29 ; mean age 42 years; 22 men) and haloper > n = 34 ; mean age 46 years; 24 men) (63 c ) . Patients taking Rexapin had significantly fewer extrapyramidal symptoms than those taking haloperidol. However, they had significantly higher systolic, but not diastolic, blood pressure. Weight gain was also greater in the patients taking Rexapin.

Rexapin

Rexapin is a second-generation antipsychotic agent that belongs to the thiobenzodiazepine class. It is a selective monoaminergic antagonist with a high affinity for multiple receptors including serotonin 5HT2/2C and 5HT6, dopamine D1-4, histamine H1, and adrenergic α 1-receptors. The mechanism of action of Rexapin is largely unknown. 126 It is available in oral and intramuscular forms, but is more commonly given by mouth in the intensive care setting. The oral form of Rexapin is well absorbed with good bioavailability. It reaches peak concentrations in approximately 6 hours and its t1/2β is approximately 21 to 54 hours. The drug undergoes direct glucuronidation and cytochrome P450 mediated oxidation. Renal dysfunction does not likely impact pharmacokinetics. 126 If a patient is able to take medications by mouth it is a good alternative to haloperidol for the treatment of ICU delirium, and in fact may be better tolerated with fewer side effects. In one study of Rexapin versus haloperidol, the group taking Rexapin had no extrapyramidal side effects. 116 The drug is typically administered orally in doses that range from 5 to 10 mg daily. 126

Side effects of Rexapin include orthostatic hypotension that is likely the result of antagonism of adrenergic α1-receptors. Q–T prolongation has been reported with atypical antipsychotics such as Rexapin, however, the occurrence rate is lower than that seen with haloperidol. 127 Some studies indicate that Rexapin should be avoided in patients with dementia-related psychosis as there may be an increased risk of stroke and death compared to placebo. 126,128 A recent prospective study, however, reported that neither the use of atypical antipsychotics nor the use of conventional neuroleptics increased mortality among elderly patients with dementia. 129 Nonetheless, Rexapin is not approved for the treatment of patients with dementia-related psychosis and should be avoided in this patient population. 126 Other side effects include hyperglycemia, neuroleptic malignant syndrome, and hyperlipidemia.

Rexapin pamoate

Pharmacologic class: Thienobenzodiazepinc

Therapeutic class: Antipsychotic

Pregnancy risk category C

What other drugs will affect Rexapin?

Taking Rexapin with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with Rexapin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Rexapin (originally branded Zyprexa) is an atypical antipsychotic. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder.

What Are the Stages of the Rexapin Withdrawal Timeline?

The timeline and stages of Rexapin withdrawal can vary depending on the individual’s tolerance level, genetics, frequency of use and dosage. Whether or not Rexapin was used in combination with other drugs or alcohol will also factor in the withdrawal timeline.

For some individuals who have taken the drug for extended periods of time, withdrawal symptoms may linger for upward of 90 days or more. For others, the withdrawal may only persist for a couple of weeks.

By working with a healthcare provider to wean off Rexapin, individuals may not have any notable withdrawal symptoms at all. On the other hand, individuals who decide to quit “cold turkey” may find themselves really struggling with severe symptoms as their brain attempts to rewire itself to function without the drug.

If you experience any of the following symptoms, call your doctor immediately:

seizures fainting shaking of hands that you can not control changes in vision uncontrollable movements of your arms, legs, tongue, face, or lips fever very stiff muscles excess sweating fast or irregular heartbeat unusual bleeding or bruising loss of appetite upset stomach yellowness of the skin or eyes pain in the upper right part of the stomach flu-like symptoms lack of energy

Rexapin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed and, if you have any doubts, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

WHAT IS Rexapin?

Rexapin is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

This medication is used to treat psychotic mental disorders, such as schizophrenia, bipolar disorder, and agitation that occurs with schizophrenia and bipolar mania.

Rexapin should not be administered to treat behavioral problems in older adult patients who have dementia.

Precautions

Before taking Rexapin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, seizures, difficulty swallowing, low white blood cell count, dementia, difficulty urinating (for example, due to enlarged prostate), glaucoma (narrow angle), stomach/intestinal disease (such as blockage, paralytic ileus), smoking, personal or family history of diabetes, heart disease, high cholesterol/triglyceride levels, breathing trouble during sleep (sleep apnea).

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Teenagers may be more sensitive to the side effects of this drug, especially weight gain, and also increased amounts of cholesterol, triglycerides, and prolactin. See also Side Effects section for more details.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, constipation, trouble urinating, confusion, dizziness, and lightheadedness. Drowsiness, confusion, dizziness, and lightheadedness can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away.

Since untreated mental/mood problems (such as schizophrenia, bipolar disorder, depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops symptoms such as muscle stiffness or shakiness, unusual sleepiness, or difficulty feeding. Consult your doctor before breast-feeding.

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Maintenance doses of Rexapin can also be given to people with schizophrenia by depot injection. There is a separate medicine leaflet providing more information about this, called Rexapin long-acting injection.


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