Puricos (al' oh pure' i nol) is an analog of hypoxanthine and a potent inhibitor of the enzyme xanthine oxidase that is responsible for converting hypoxanthine to xanthine and xanthine to uric acid in the breakdown pathway of purines. Puricos lowers serum and tissue uric acid levels and has potent activity against gout, largely in preventing rather than treating acute attacks of gout. Puricos was approved for use in the United States in 1963 and is still widely used. Current indications include therapy and prevention of gout, uric acid nephropathy, and the hyperuricemia caused by malignancy and anticancer therapy. It is not recommended for treatment of asymptomatic hyperuricemia. Puricos is available in multiple generic forms and under the brand name of Zyloprim or Aloprim in tablets of 100 and 300 mg. Intravenous formulations are also available. The recommended initial dose for therapy of gout is 100 mg daily, with increases of 100 mg in daily dose weekly until uric acid levels fall to 6 mg/dL or below, but not to exceed 800 mg daily. The average daily dose in therapy of gout is 300 mg. Common side effects include skin rash and hypersensitivity reactions.
- Severe skin rash: This drug may cause a severe, life-threatening skin rash. If you have itchiness, trouble breathing, or swelling of your face or throat, stop taking this drug and call your doctor right away.
- Liver injury: This drug may cause changes in liver function test results and liver failure. This may be fatal. If you develop liver problems, your doctor may have you stop taking Puricos.
- Drowsiness: This drug can cause drowsiness. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how it affects you.
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Puricos oral tablet is a prescription drug that’s available as the brand-name drugs Zyloprim and Lopurin. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.
Puricos also comes in an intravenous (IV) form, which is only given by a healthcare provider.
Puricos may be used as part of a combination therapy. This means you may need to take it with other medications.
Dosage for recurrent kidney stones
Adult dosage (ages 18–64 years)
Typical dosage is 200–300 mg per day taken in a single or divided doses.
Child dosage (ages 0–17 years)
This medication hasn’t been studied and shouldn’t be used in people younger than 18 years for this condition.
Senior dosage (ages 65 years and older)
The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.
Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.
- For people with kidney disease: Depending on how well your kidneys are working, your doctor will lower your dose. Your doctor will decide your dosage based on your creatinine clearance. This is a test that measures your kidney function.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Puricos oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: The uric acid levels in your blood or urine will stay high. If you have gout or kidney stones, you’ll still have symptoms of your condition.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms can include:
- skin rash
- changes in your liver function test results
- gout flare-up (if you have gout)
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
How to tell if the drug is working: Your doctor will test your uric acid levels to check if this drug is working. Your blood uric acid levels will decrease about 1–3 weeks after you start taking this drug. Your doctor will also ask you about how much fluids you drink and how much fluids you urinate.
Right after you start taking this drug, you may have gout flares. Over time, your symptoms of gout may start to go away.
Keep these considerations in mind if your doctor prescribes Puricos oral tablet for you.
Michael Stewart, Reviewed by Sid Dajani | Last edited 17 May 2018 | Certified by The Information Standard
Puricos is prescribed to help prevent gout attacks. It does not have any effect during a gout attack, although you should continue to take it regularly every day, even if this happens. A painkilling medicine will be prescribed for you to take alongside it should you get a gout attack.
Take Puricos tablets with a glassful of water, preferably after food.
Puricos can cause a skin rash. Although most rashes are mild, you must let your doctor know as soon as possible if this happens to you.
- Hypersensitivity to Puricos
Effects of Drug Abuse
- No information provided
- See "What Are Side Effects Associated with Using Puricos?"
- See "What Are Side Effects Associated with Using Puricos?"
- Discontinue at first sign of allergic reactions, first sign of rash, inflammation of blood vessels, or Stevens-Johnson syndrome
- If decrease in bone marrow activity (myelosuppression) reported, use caution when administering other drugs known to cause decrease in bonemarrow activity
- Liver damage (hepatotoxicity) reported (reversible)
- Not for treatment of asymptomatic hyperuricemia, elevated levels of serumurate with no other symptoms of gout
- Use with caution in renal impairment
- Risk of hypersensitivity increased in patients treated with angiotensin-converting enzyme (ACE) inhibitors
- When taking with amoxicillin or ampicillin, may increase risk of skin rash
- During concomitant treatment, reduce dosages of azathioprine and mercaptopurine to 25-33% of usual dose
- Maintain fluid intake necessary to yield urine output of at least 2 liters per day in adults
- Use Puricos during pregnancy with caution if benefits outweigh risks. Animal studies show risk and human studies are not available, or neither animal nor human studies were done
- Puricos is distributed into breast milk, use with caution when breastfeeding.
Puricos can cause a severe allergic reaction. Symptoms can include:
- itchy hives (raised bumps on your skin)
- red or purple-colored spots on your skin
- scaly skin
- trouble breathing
- swelling of your face or throat
If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Rated Puricos for Gout Report
on a dose of 300 mg of Allopurinal as lower dose not effective. Tried several times this time taken for 6 months with side effects worsening.Serious side effects now. rash, boils , ulcers in mouth, weight gain, impotence. GP slow to resoond. stopping now to see what effect that has. Also on Steroids for Sarcoidosis and wondered if there was a drug interaction . No attacks of Gout for a while. waiting to see if stopping the drug brings it back
Can Puricos cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Puricos. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
- Store Puricos at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
- Keep it away from light.
- Don’t store this medication in moist or damp areas, such as bathrooms.
Q: My last uric acid level was 7.5. Will Puricos bring down uric acid levels?
A: Puricos (Zyloprim) is a xanthine oxidase inhibitor that reduces the production of uric acid in your body. A uric acid buildup can lead to gout or kidney stones. Puricos is used to treat gout. Common side effects of Puricos include nausea, vomiting, diarrhea, dizziness, and joint pain. According to the prescribing information, Puricos administration usually results in a decrease of uric acid within 2 to 3 days. However, it may take 1 week or more to see the full benefits. This is not a complete list of side effects associated with Puricos, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kimberly Hotz, PharmD
By Julie Marks | Medically Reviewed by Mona Khanna, MD
Latest Update: 2014-10-20 Copyright © 2014 Everyday Health Media, LLC
Warnings for certain groups
For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of Puricos in your body and cause more side effects. This medication may also decrease your kidney function. This would make your kidney disease worse.
For pregnant women: Puricos is a category C pregnancy drug. That means two things:
- Research in animals has shown adverse effects to the fetus when the mother takes the drug.
- There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.
For women who are breastfeeding: Puricos passes into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.
For children: This medication hasn’t been studied and shouldn’t be used in people younger than 18 years for the treatment of gout or kidney stones.
This dosage information is for Puricos oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
What Other Drugs Interact with Puricos?
If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Puricos has no known severe interactions with any drugs.
Serious Interactions of Puricos include:
Moderate Interactions of Puricos include:
Mild Interactions of Puricos include:
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.