Prodec tablets


  • Active Ingredient: Allopurinol
  • 300 mg
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What is Prodec?

The active ingredient of Prodec brand is allopurinol. Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. Each scored orange tablet contains 300 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. Its solubility in water at 37В°C is 80 mg/dL and is greater in an alkaline solution.

Used for

Prodec is used to treat diseases such as: Calcium Oxalate Calculi with Hyperuricosuria, Cardiothoracic Surgery, Gout, Heart Failure, High Risk Percutaneous Transluminal Angioplasty, Hyperuricemia Secondary to Chemotherapy, Leishmaniasis, Mania, Reactive Perforating Collangenosis, Urinary Tract Stones.

Side Effect

Possible side effects of Prodec include: rapid weight gain; drowsiness; loss of appetite; depression; blue or pale skin; severe stomach pain.

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Q: I've been prescribed Prodec. What are its side effects?

A: The main side effect from Zyloprim (the generic name is Prodec) is skin related. In more than 10 percent of people taking Zyloprim (Prodec), skin rash; scaling skin; dark red, raised hives; or purple spot lesions have been reported, as has Stevens-Johnson syndrome (a possibly life-threatening skin condition where the cell death causes the epidermis to separate from the dermis). Less common side effects, in 1 to 10 percent of the population, include drowsiness, chills, fever, alopecia, nausea, vomiting, diarrhea, abdominal pain, gastritis, dyspepsia, and abnormal liver tests. If you aren't tolerating Prodec and show any side effects, you should contact your doctor. Patti Brown, PharmD

How to take Prodec

  • Before you start the treatment, read the manufacturer's printed information leaflet from ins >

Generic Name: Prodec (AL oh PURE i nol)Brand Names: Zyloprim, Lopurin, Aloprim

Medically reviewed by Sanjai Sinha, MD Last updated on Dec 17, 2018.


  • Take this drug at the time(s) recommended by your doctor.
  • You can take Prodec with or without food.
  • Taking this drug after a meal and with lots of water may reduce your chance of upset stomach.
  • You can cut or crush the Prodec tablet.
  • Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Severe skin rash. Symptoms can include:
    • itchy hives (raised bumps on your skin)
    • red or purple-colored spots on your skin
    • scaly skin
    • fever
    • chills
    • trouble breathing
    • swelling of your face or throat
  • tiredness
  • lack of appetite
  • weight loss
  • right upper abdominal area pain or discomfort
  • jaundice (dark-colored urine or yellowing of your skin or the whites of your eyes)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Prodec oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

What is Prodec and how is it used?

Prodec (al-oh-pure-ri-nol) is mainly used for the long-term treatment and prevention of gout. Taken regularly, it can stop attacks of gout and help prevent damage to your joints.

It can also be used for treating kidney stones.

The body naturally produces a substance called urate. This normally dissolves in your blood until it’s passed out of the body in your urine. When too much urate is produced, or if your body can’t get rid of it properly, crystals can form in and around your joints. This causes pain and inflammation.

Prodec blocks an enzyme that is involved in producing urate. This helps the crystals to dissolve and stops attacks of gout.

Prodec can lower the urate levels in your blood over the space of a few weeks. This will stop new crystals forming.

It can take longer to dissolve crystals that are already there, and you may have more attacks of gout during this time. This is more likely to happen if your urate levels are very high or you’ve had gout for a long time. If this happens to you, it doesn’t mean that your Prodec isn’t working.

Attacks of gout usually stop within a year, as long as your urate level has gone down enough.

Your doctor will usually be cautious about prescribing Prodec if you have kidney, thyroid or liver problems.

You will usually be offered Prodec for gout if blood tests show that your urate level is high and one or more of the following applies:

  • You keep having attacks of gout.
  • Your joints or kidneys have been damaged by attacks of gout.
  • Your skin has been affected by deposits of urate crystals.

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If you have had a number of gout attacks, your doctor will advise that you take a medicine every day to help prevent more attacks from occurring. Prodec is the medicine which is most commonly prescribed for this. It helps to prevent gout attacks by reducing the levels of uric acid in your blood. As it is not a painkiller, it does not have any effect during a gout attack, so you will still need to take pain relief should you have any further attacks. In this case, your doctor will prescribe either an anti-inflammatory painkiller or colchicine for you to take alongside Prodec.

Prodec can also help prevent uric acid levels building up in some other conditions too. These include some types of kidney stones, and during some treatments for cancer. It works in these conditions by lowering the levels of uric acid in blood.


Experience with human pregnancy limited partly because women of reproductive age rarely require treatment with drug; in 2011, a literature publication case report describes outcome of a full term pregnancy in a 35 year-old woman who had recurrent kidney stones since age 18 who took Prodec throughout pregnancy; the child had multiple complex birth defects and died at 8 days of life; a second report on 31 prospectively ascertained pregnancies involving mothers exposed to Prodec for varying durations during first trimester; the overall rate of major fetal malformations and spontaneous abortions was reported to be within normal expected range; however, one child had severe malformations similar to those described in earlier case report

What other drugs will affect Prodec?

Tell your doctor about all your other medicines, especially:

a blood thinner such as warfarin, Coumadin, Jantoven; or

a diuretic or "water pill".

This list is not complete. Other drugs may interact with Prodec, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

How to store Prodec

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.



ZYLOPRIM (Prodec) reduces serum and urinary uric acid concentrations. Its use should be individualized for each patient and requires an understanding of its mode of action and pharma-cokinetics (see CLINICAL PHARMACOLOGY, CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS). ZYLOPRIM (Prodec) is indicated in:

  1. the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy).
  2. the management of patients with leukemia, lymphoma and malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels. Treatment with ZYLOPRIM (Prodec) should be discontinued when the potential for overproduction of uric acid is no longer present.
  3. the management of patients with recurrentcalcium oxalate calculi whose daily uric acid excretion exceeds 800 mg/day in male patients and 750 mg/day in female patients. Therapy in such patients should be carefully assessed initially and reassessed periodically to determine in each case that treatment is beneficial and that the benefits outweigh the risks.

Rated Prodec for Gout Report

Was taking colcrys for a while which made me sick. Switched to allipurinol. Was getting attacks about one every 2 months for about 2 years. Since switching, have only had 1 attach in the past year.

What Is Prodec and How Does It Work?

Prodec is a prescription medication used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receiving chemotherapy. These patients can have increased uric acid levels due to the release of uric acid from the dying cancer cells. Prodec works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout and kidney problems.

Prodec is available under the following different brand names: Zyloprim and Aloprim.

Dosages of Prodec:

Adult and pediatric dosages:

Powder for injection

Dosage Considerations – Should be Given as Follows:

  • Adult dosage:
  • Mild: 100 mg per day orally initially, increased weekly to 200-300 mg per day
  • Moderate to severe: 100 mg per day orally initially, increased weekly to 400-600 mg per day

Excess of Uric Acid (Hyperuricemia)

  • Pediatric dosage:
  • 10 mg/kg per day orally divided every 12 hours, not to exceed 600 mg/day

Antineoplastic-Induced Excess of Uric Acid (Hyperuricemia)

  • Pediatric dosage:
  • 10 mg/kg per day orally divided every 12 hours, not to exceed 600 mg/day
  • Adult dosage:
  • 600-800 mg divided every 8-12 hours, starting 1-2 days before chemotherapy
  • Intravenously: 200-400 mg/m2 per day, not to exceed 600 mg/m2 per day, may administer as single infusion or in equally divided doses at 6, 8, and 12 hour intervals beginning 1-2 days before chemotherapy
  • Dosing considerations:
  • Minimum oral dosage: 100-200 mg/day
  • Maximum oral dosage: 800 mg/day
  • Dosing modifications:
  • Creatinine clearance 10-20 ml/min: 200 mg/day
  • Creatinine clearance 3-10 ml/min: 100 mg/day
  • Creatinine clearance less than 3 ml/min: 100 mg/day at extended intervals

Rated Prodec for Gout Report

i ralize this is not a review of the drug-this is in fact the contents of one sachet of urals if anyone is desparate. Sodium Bicarbonate 1.76 grams which is 3/8 of a teaspoon Citric Acid powder 0.72 grams which is 1/8 of a teaspoon Tartaric Acid pwdr 0.89 grams which is 1/8++ teaspoon Sodium Citrate 0.63 grams which is 1/8+ teaspoon i could not find anywhere else to put the info

Before taking Prodec

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Prodec it is important that your doctor knows:

  • If you are pregnant or breastfeeding.
  • If you have any problems with the way your liver works, or any problems with the way your k >


1. "Product Information. Zyloprim capsules (Prodec)." Glaxo Wellcome, Research Triangle Park, NC.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

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