When the level of Phenydan reaches the toxic level, the patient may manifest with a febrile reaction and bradycardia. If the patient receives Phenydan intravenously, they may experience hypotension or low blood pressure. Oral intake of the drug is associated with the presence of gingival hyperplasia .
Loading Dose: A loading dose of parenteral Phenydan Sodium Injection should be injected slowly, not exceeding 50 mg per minute in adults and 1-3 mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients.
Infusion: For infusion administration, parenteral Phenydan Sodium Injection should be diluted in normal saline with the final concentration of Phenydan sodium in the solution no less than 5 mg/mL. Administration should commence immediately after the mixture has been prepared and must be completed within 1 to 4 hours (the infusion mixture should not be refrigerated). An in-line filter (0.22-0.55 microns) should be used.
Sample dilution: Total volume: Drug plus solution - 200 ml. Conc: 5 mg/mL.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
The diluted infusion mixture (Phenydan Sodium Injection plus normal saline) should not be refrigerated. If the undiluted parenteral Phenydan Sodium Injection is refrigerated or frozen, a precipitate might form: this will dissolve again after the solution is allowed to stand at room temperature. The product is still suitable for use. A faint yellow coloration may develop, however this has no effect on the potency of the solution.
On this page
- About Phenydan
- Key facts
- Who can and can't take Phenydan
- How and when to take it
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
What if I take too much?
Taking too much Phenydan by accident can cause unpleasant side effects.
- DRESS, also known as multiorgan hypersensitivity, reported in patients taking antiepileptic drugs, including Phenydan and fosPhenydan
- Some of these events have been fatal or life-threatening
- DRESS typically, although not exclusively, presents with fever, rash, lymphadenopathy, and/or facial swelling, in association with other organ system involvement (eg, hepatitis, nephritis, hematological abnormalities, myocarditis, or myositis sometimes resembling an acute viral infection); eosinophilia is often present
- Early manifestations of hypersensitivity (eg, fever or lymphadenopathy) may be present even though rash is not evident
- If such signs or symptoms are present, evaluate patient immediately; discontinue drug if unable to confirm other etiology for the rash
How should I take Dilantin?
Take Dilantin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Swallow an extended-release capsule whole and do not crush, chew, break, or open it.
Dilantin Infatabs chewable tablets are not for once-per-day dosing. You must take them 2 or 3 times per day. Follow your doctor's dosing instructions very carefully.
Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
You may need frequent blood tests. You may also need a blood test when switching from one form of Phenydan to another. Visit your doctor regularly.
Tell your doctor if Dilantin does not seem to work as well in controlling your seizures. Do not stop using Dilantin suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.
In case of emergency, wear or carry medical identification to let others know you have seizures.
Phenydan can cause swelling in your gums. Brush and floss your teeth and visit your dentist regularly to help prevent this problem.
Store at room temperature away from moisture, light, and heat.
Common side effects
These common side effects may happen in more than 1 in 100 people. They're usually mild and go away by themselves.
Keep taking the medicine and talk to your doctor or pharmacist if these side effects bother you or do not go away:
- feeling drowsy, sleepy or dizzy
- feeling nervous, unsteady or shaky
- feeling or being sick (nausea or vomiting)
- sore or swollen gums
- mild skin rash
Some side effects of Phenydan wear off once your body gets used to the medicine, but it can take several weeks or months.