Warnings for people with certain health conditions
For people with risk factors for heart arrhythmias: If you have conditions such as heart failure or congenital long QT syndrome, this drug may increase your risk of arrhythmias. Ask your doctor if you have risk factors for arrhythmias.
For people with phenylketonuria: The Onilat orally disintegrating tablet contains phenylalanine. This amino acid can cause dangerous effects in people with a condition called phenylketonuria. Don’t take the orally disintegrating tablet if you have phenylketonuria.
What Other Drugs Interact with Onilat?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Severe Interactions of Onilat include:
Onilat has serious interactions with at least 119 different drugs.
Onilat has moderate interactions with at least 53 different drugs.
Onilat has minor interactions with at least 28 different drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
What other drugs will affect Onilat?
Onilat can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Onilat.
Taking Onilat while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use:
medicine to treat depression;
medicine to treat a psychiatric disorder;
a narcotic (opioid) medication; or
medicine to prevent nausea and vomiting.
This list is not complete and many other drugs can interact with Onilat. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
You should not use Onilat if you are also using apomorphine (Apokyn).
You should not use Onilat if you are allergic to it or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).
Before taking Onilat, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.
Onilat orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Serious side effects of Onilat include blurred vision or temporary vision loss (lasting from only a few minutes to several hours), slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating less than usual or not at all. Stop taking this medicine and call your doctor at once if you have any of these side effects. Onilat may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Can taking Onilat during pregnancy cause other pregnancy complications?
Studies did not find a higher chance of miscarriage, premature delivery (being born before 37 weeks of pregnancy), or low birth weight when women used Onilat during pregnancy.
At higher doses, there have been reports that Onilat use might cause a heart rhythm problem (called QT interval prolongation) in the person taking Onilat. In severe cases, this could become an abnormal heart rhythm known as Torsades de Pointes. You can discuss how to monitor for QT interval prolongation with your healthcare provider is you are using this medication.
Onilat can cause a severe allergic reaction. Symptoms can include:
- trouble breathing
- swelling of your throat or tongue
If you develop these symptoms, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Does taking Onilat increase the chance for miscarriage?
One study did not find a higher rate of miscarriage among women who reported using Onilat in the first trimester of pregnancy.
What Is Zofran (Onilat)?
Zofran is a brand name for the drug Onilat, prescribed to treat or prevent nausea and vomiting.
Doctors sometimes prescribe Zofran to treat nausea and vomiting caused by cancer treatments such as chemotherapy and radiation therapy.
Zofran also can treat nausea and vomiting after surgery.
The drug may also help prevent the common complication of shivering in people who have had anesthesia.
Some doctors have prescribed Zofran off-label to treat nausea and vomiting caused by morning sickness in pregnant women, though the drug has never been approved for this use.
Zofran blocks serotonin, a natural substance in the brain that may contribute to nausea and vomiting.
It belongs to a class of drugs called serotonin 5-HT3 receptor antagonists. These drugs are antiemetics, meaning they block nausea and vomiting.
The Food and Drug Administration (FDA) approved Onilat in 1992 under the brand name Zofran for GlaxoSmithKline.
In 2007, the FDA approved generic Onilat for several drug companies.
Table 1: Adult Recommended Dosage Regimen for Prevention of Nausea and Vomiting
Indication Dosage Regimen Highly Emetogenic Cancer Chemotherapy A single 24 mg dose administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin greater than or equal to 50 mg/m 2 Moderately Emetogenic Cancer Chemotherapy 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8 mg dose 8 hours after the first dose.
Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy. Radiotherapy For total body irradiation: 8 mg administered 1 to 2 hours before each fraction of radiotherapy each day.
For single high-dose fraction radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8 mg doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy.
For daily fractionated radiotherapy to the abdomen: 8 mg administered 1 to 2 hours before radiotherapy, with subsequent 8 mg doses every 8 hours after the first dose for each day radiotherapy is given. Postoperative 16 mg administered 1 hour before induction of anesthesia.
Table 2: Pediatric Recommended Dosage Regimen for Prevention of Nausea and Vomiting
Generic Name: Onilat (oral) (on DAN se tron)Brand Names: Zofran, Zofran ODT, Zuplenz
Medically reviewed by Drugs.com. Last updated on Nov 4, 2019.