Onfran tablets


  • Active Ingredient: Ondansetron
  • 8 mg, 4 mg
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What is Onfran?

The active ingredient of Onfran brand is ondansetron. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. The molecular formula is C18H19N3O•HCl•2H2O, representing a molecular weight of 365.9. Ondansetron HCl dihydrate is a white to off-white powder that is soluble in water and normal saline. Each 4 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 4 mg of Ondansetron. Each 8 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 8 mg of Ondansetron. Each tablet also contains the inactive ingredients croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, titanium dioxide, triacetin, and iron oxide yellow (8 mg tablet only). This product meets USP Dissolution Test 3.

Used for

Onfran is used to treat diseases such as: Alcohol Dependence, Gastroenteritis, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Nausea/Vomiting, Radiation Induced, Obsessive Compulsive Disorder, Postanesthetic Shivering, Pruritus.

Side Effect

Possible side effects of Onfran include: unconscious; difficulty with swallowing; sticking out of the tongue; hyperventilation; noisy breathing; muscle trembling, jerking, or stiffness.

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What Are Side Effects Associated with Using Onfran ?

Side effects of Onfran include:

Other side effects of Onfran include:

  • heart rate irregularities (including ventricular and supraventricular tachycardia, premature ventricular contractions, and atrial fibrillation)
  • slow heart rate
  • electrocardiographic alterations (including second-degree heart block, QT/QTc interval prolongation, and ST segment depression)
  • palpitations
  • fainting (rarely and predominantly with intravenous Onfran)
  • transient ECG changes including QT/QTc interval prolongation have been reported

  • ECG alterations: heart beat irregularities; prolongation of PR, QRS, and QT intervals

  • specific hepatic enzyme abnormalities
  • hepatic necrosis
  • abnormal hepatic function

  • flushing
  • rare cases of hypersensitivity reactions, sometimes severe (acute allergic reactions, rapid swelling, difficulty breathing, cardiopulmonary arrest, low blood pressure, laryngealedema, laryngospasm, shock, shortness of breath, or stridor)

  • pain, redness, and burning at injection site

  • involuntary intermittent or sustained deviation of the eyes, appearing alone, as well as with other dystonic reactions; transient dizziness during or shortly after intravenous infusion

  • Transient blindness (predominantly during IV administration) reported to resolve within a few minutes up to 48 hr;
  • transient blurred vision

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

How to store Onfran

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.



This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. Onfran works by blocking one of the body's natural substances (serotonin) that causes vomiting.

Can I take Onfran while breastfeeding?

Little published information is available on the clinical use of Onfran during breastfeeding, although it is apparently frequently used for nausea after cesarean section, usually in doses of 4 to 8 mg intravenously. No adverse infant effects have been reported and the drug has been used in infants. If Onfran is required by the mother, it is not a reason to discontinue breastfeeding; however an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Helen Allen, Reviewed by Dr John Cox | Last edited 28 Dec 2016 | Certified by The Information Standard

Onfran is an anti-sickness medicine.

It will start to work within 1-2 hours.

The most common side-effects are a headache, constipation, and feeling flushed.

How should this medicine be used?

Onfran comes as a tablet, a rapidly disintegrating (dissolving) tablet, film, and an oral solution (liquid) to take by mouth. The first dose of Onfran is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Additional doses are sometimes taken one to three times a day during chemotherapy or radiation therapy and for 1 to 2 days after the end of treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Onfran exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Do not chew the film.

If you are taking the rapidly disintegrating tablet, remove the tablet from the package just before you take your dose. To open the package, do not try to push the tablet through the foil backing of the blister. Instead, use dry hands to peel back the foil backing. Gently remove the tablet and immediately place the tablet on the top of your tongue. The tablet will dissolve in a few seconds and can be swallowed with saliva.

Special dosage considerations

For people with liver disease: If you have severe liver disease, you should not take more than 8 mg of Onfran per day.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Onfran orally disintegrating tablet is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: You could have nausea and vomiting that’s not controlled.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • faintness
  • drowsiness
  • agitation
  • fast heartbeat
  • flushing (sudden reddening of the skin)
  • seizures

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

How to tell if the drug is working: You should not have nausea or vomiting. If you do, it should be less severe.

Keep these considerations in mind if your doctor prescribes Onfran for you.


Appropriate studies have not been performed on the relationship of age to the effects of Onfran in children younger than 4 years of age. Safety and efficacy have not been established.

What Are Warnings and Precautions for Onfran?

  • This medication contains Onfran. Do not take Zofran, Zofran ODT, or Zuplenz if you are allergic to Onfran or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

  • Hypersensitivity
  • Coadministration with apomorphine; combination reported to cause profound low blood pressure and loss of consciousness

Effects of Drug Abuse

  • Onfran may mask progressiveileus or gastricdistention in patients who are undergoing abdominal surgery or experiencing chemotherapy-induced nausea and vomiting; monitor for decreased bowel activity, particularly in patients with risk factors for gastrointestinal obstruction
  • See also "What Are Side Effects Associated with Using Onfran?”

  • See also "What Are Side Effects Associated with Using Onfran?”

  • Hypersensitivity reactions including anaphylaxis and bronchospasm may occur: discontinue therapy if suspected; monitor and treat promptly per standard of care until signs and symptoms resolve
  • Reduce dose with severe hepatic impairment
  • Use according to schedule, not as needed
  • Onfran may mask progressive ileus or gastric distention in patients who are undergoing abdominal surgery or experiencing chemotherapy-induced nausea and vomiting; monitor for decreased bowel activity, particularly in patients with risk factors for gastrointestinal obstruction
  • Onfran is not a drug that stimulates gastric or intestinal peristalsis; should not be used instead of nasogastric suction
  • Serotonin syndrome reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs including SSRIs, SNRIs, MAO inhibitors, lithium, tramadol, methylene blue IV, and mirtazapine; if concomitant use with other serotonergic drugs is clinically warranted, patients should be made aware of potential increased risk for serotonin syndrome
  • Cross-sensitivity among selective serotonin antagonists may occur
  • Zofran ODT contains phenylalanine (caution for phenylketonurics)
  • Dose-dependent QT prolongation; avoid in patients with congenitallong QT syndrome; ECG monitoring recommended in patients who have electrolyte abnormalities, chronicheart failure, or bradyarrhythmias or who are also receiving other medications that cause QT prolongation

Pregnancy and Lactation with Onfran

  • Available data do not reliably inform of association with adverse fetal outcomes when Onfran is used during pregnancy; published epidemiological studies on the association between Onfran and fetal outcomes have reported inconsistent findings and have important methodological limitations hindering interpretation
  • It is not known whether Onfran is present in human milk; there are no data on effects of Onfran on breastfed infant or effects on milk production; the developmental and health benefits of breastfeeding should be considered along with mother's clinical need for Onfran and any potential adverse effects on breastfed infant from therapy or from the underlying maternalcondition

Adult Dose for Nausea/Vomiting – Postoperative

  • Use: Prevention of postoperative nausea and vomiting

Oral Onfran:

  • Recommended dose: 16 mg orally 1 hour before the induction of anesthesia

Parenteral Onfran:

  • Recommended dose: 4 mg IV (undiluted) immediately before induction of anesthesia or postoperatively (nausea and/or vomiting within 2 hours after surgery)
  • Alternative route: 4 mg IM (undiluted)


    Onfran is an anti-sickness medicine. It is known as a serotonin receptor antagonist. It is prescribed to stop you from feeling sick. It works by blocking the effect of a naturally produced chemical in your body, called serotonin. Serotonin is also referred to as 5HT3.

    Dictionary Entries near Onfran

    Cite this Entry

    “Onfran.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/Onfran. Accessed 27 December 2019.

    Comments on Onfran

    What made you want to look up Onfran? Please tell us where you read or heard it (including the quote, if possible).

    Getting the most from your treatment

    • Onfran should start to work within an hour or so. If you are taking tablets or liquid medicine and you are sick within one hour of taking a dose, you should take the same dose again. This does not apply, however, if you are using suppositories or if you have been given an injection, as being sick will not prevent these from being absorbed by your body.
    • Even if you do not feel like eating or drinking, try to sip water regularly to prevent you from becoming lacking in fluids (dehydrated). Also, rather than trying to eat three main meals a day, try eating small, simple but nourishing snacks, every few hours.

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