Medotrigin tablets


  • Active Ingredient: Lamotrigine
  • 200 mg, 100 mg, 50 mg, 25 mg
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What is Medotrigin?

The active ingredient of Medotrigin brand is lamotrigine. Lamotrigine is an anti-epileptic medication, also called an anticonvulsant. Lamotrigine tablets, USP are supplied for oral administration as 25 mg, 100 mg, 150 mg or 200 mg tablets. Each tablet contains the labeled amount of Lamotrigine and the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, pregelatinized starch (corn) and sodium lauryl sulfate. In addition, the 200 mg tablets contain D&C Yellow No. 10 Aluminum Lake and FD&C Blue No. 1 Aluminum Lake. Meets USP Dissolution Test 3.

Used for

Medotrigin is used to treat diseases such as: Anxiety, Bipolar Disorder, Borderline Personality Disorder, Cyclothymic Disorder, Depression, Epilepsy, Migraine Prevention, Post Traumatic Stress Disorder, Restless Legs Syndrome, Schizoaffective Disorder, Seizure Prevention.

Side Effect

Possible side effects of Medotrigin include: bleeding gums; changes in vision; swollen lymph nodes; nosebleeds; lightheadedness; loss of balance control; tic-like (jerky) movements; flu-like symptoms.

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Having epilepsy means that you have had more than one unexplained fit, or seizure. A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Different parts of the brain control different functions of your body, so the symptoms that occur during a seizure will depend on where the abnormal burst of electrical activity occurs. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, consciousness, or a combination of these. The seizures can be prevented in most people by suitable antiepileptic medication. Medotrigin is a commonly used medicine. It works by stabilising the electrical activity of your brain, which helps to prevent the seizures from occurring.

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Can Medotrigin cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Medotrigin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

What Other Drugs Interact with Medotrigin?

If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider or pharmacist first.

Medotrigin has no known severe interactions with other drugs.

Medotrigin has no known serious interactions with other drugs.

Medotrigin has moderate interactions with at least 34 different drugs.

Medotrigin has mild interactions with at least 23 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Q: Can Lamictal cause strange dreams to occur and waking up in the middle of the night?

A: Lamictal (Medotrigin) is an anti-seizure medicine that is used to treat bipolar disorder. According to the package insert, the most common side effects of Lamictal are headache, rash and itching, dizziness, diarrhea, and abnormal dreams. This is not a complete list of the side effects associated with Lamictal. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Some other possible causes of nightmares include having a late-night snack, which can increase metabolism and brain activity; withdrawal from medications and substances such as alcohol; sleep deprivation or sleep disorders; and psychological disorders such as anxiety and depression. If you think a drug you are taking is causing bad dreams, tell your health care provider. Do not stop any medication or change the dose without first talking to your provider. Tell your health care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting or by calling 1-800-FDA-1088. Michelle McDermott, RPh, PharmD

Q: Can Lamictal make your urine dark? If so, does it mean it is affecting your liver in a bad way?

A: Lamictal (Medotrigin) is a medication that is used to treat various conditions, including epilepsy and bipolar disorder. It is not known exactly how this medication works to relieve the symptoms of those conditions, but it is thought to have some activity affecting the chemicals in the brain. According to the prescribing information for Lamictal, the most common side effects of this medication include dizziness, double vision, headaches, nausea, drowsiness, stomach pain, insomnia, heartburn, and diarrhea. If you experience anything unusual or bothersome while taking Lamictal, report them to your physician. Liver problems can occur, very rarely, with this medication and if you are experiencing dark-colored or cola colored urine you should report this to your physician immediately, especially if you are noticing a yellowing of the skin or eye color, have fever, nausea/vomiting, or feel more tired than usual. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

Q: Is there a cheaper alternative to Lamictal? I had to stop taking and since stopping it, I'm having problems again.

A: Lamictal (generic name Medotrigin) is used to control seizures and also for a mood stabilizer for bipolar disorder. The generic for Lamictal or Medotrigin is available in the United States. Check with local pharmacies for prices on the generic drug. There are also patient assistance programs by some pharmaceutical companies for individuals that cannot afford their medication. Glaxo-Smith-Kline markets the drug Lamictal and information for their assistant program is: Lamictal Glaxo Wellcome Inc. Glaxo Wellcome Patient Assistance Program P.O. Box 52185 Phoenix, AZ 85072-9711 800/722-9294 Fax: 800/750-9832 A physician may also be able to recommend a cheaper alternative drug for the medical condition. For more information on Lamictal visit Everyday Health at // Kimberly Hotz, PharmD

Michael Stewart, Reviewed by Sid Dajani | Last edited 21 Dec 2017 | Certified by The Information Standard

Medotrigin is prescribed to treat two different conditions - epilepsy and bipolar disorder.

Take your doses regularly. Do not stop taking Medotrigin unless your doctor tells you to.

You can take your doses either before or after food.

Q: What medications should be avoided when taking Focalin and Lamictal?

A: According to the package insert for Focalin (dexmethylphenidate hydrochloride), Focalin should not be taken during treatment with monoamine oxidase inhibitors, and also within a minimum of 14 days following discontinuation of a monoamine oxidase inhibitor (hypertensive crises may result). Other drug interactions are listed in Focalin's package insert, but no other drugs are recommended to be avoided with Focalin. Although Lamictal (Medotrigin) can interact with other medications, according to the package insert, Lamictal doesn't list any medications that should not be taken with Lamictal. It is important for patients to consult their physician or healthcare provider about any patient specific questions regarding medical conditions or medications; particularly before taking any action. To learn more about Focalin: // To learn more about Lamictal: // Derek Dore, PharmD

Before taking this medicine

You should not take Medotrigin if you are allergic to it.

Medotrigin may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote).

Tell your doctor if you have ever had:

a rash or allergic reaction after taking another seizure medication;

depression, suicidal thoughts or actions; or

meningitis (inflammation of the tissue that covers the brain and spinal cord) after taking Medotrigin.

Some people have thoughts about suicide while taking Medotrigin. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of Medotrigin on the baby.

Birth control pills can make Medotrigin less effective, resulting in increased seizures. Tell your doctor if you start or stop using birth control pills. Your Medotrigin dose may need to be changed.

It may not be safe to breastfeed while using Medotrigin. Ask your doctor about any risk.

Getting the most from your treatment

  • When you first start a new treatment for epilepsy there may be a change in the number or type of seizures you experience. Your doctor will advise you about this.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • Different formulations and makes of Medotrigin can act in a slightly different way in your body. Because of this, your doctor may recommend that you continue to take Medotrigin from the same manufacturer each time you obtain a new supply. If so, each time you collect a prescription, check to make sure your supply looks the same and that the name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to advise you.
  • If you buy any medicines, check with a pharmacist that they are suitable for you to take.
  • While you are being treated for epilepsy there is a small risk that you may develop mood changes, distressing thoughts and feelings about suicide. If this happens, you must tell your doctor about it straightaway.
  • People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to start driving again. This will usually be after a year free of seizures.
  • Antiepileptic medicines can harm an unborn child. If you are a woman, make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist before you become pregnant.
  • You need to take Medotrigin regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually if this becomes necessary.
  • If you drink alcohol, ask your doctor for advice. Your doctor may advise you not to drink alcohol while you are on this medicine.
LAMICTAL ODT (Medotrigin) Patient Titration Kit For Patients Taking Carbamazepine, Phenytoin, Phenobarbital, Or Prim >50- mg, white to off-white, round, flat-faced, radius-edged tablets debossed with “LMT” on one side and “50” on the other, and 100 mg, white to off-white, round, flat-faced, radius-edged tablets debossed with “LAMICTAL” on one side and “100” on the other, blister pack of 56 tablets (42/50-mg tablets and 14/100-mg tablets) (NDC 0173-0780-00).


Before taking Medotrigin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, a certain heart rhythm disorder (Brugada syndrome).

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children may be at greater risk for skin rashes while taking this drug. See also Warning section.

Older adults may be more sensitive to the side effects of this drug, especially dizziness, loss of coordination, or fainting. These side effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. However, since untreated seizures or mental/mood problems (such as bipolar disorder) are serious conditions that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately talk to your doctor about the benefits and risks of using this medication during pregnancy. Since birth control pills, patches, implants, and injections may not work if taken with this medication (see also Drug Interactions section), discuss reliable forms of birth control with your doctor.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

6. How to cope with s >

What to do about:

  • headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if your headaches last longer than a week or are severe.
  • feeling drowsy, sleepy or dizzy - as your body gets used to Medotrigin, these side effects should wear off. Do not drive, ride a bike or operate machinery until you feel more alert. If they do not go within a week or two, your doctor may reduce your dose or increase it more slowly. If that does not work, speak to your doctor. You may need to switch to a different medicine.
  • aggression, or feeling irritable or agitated - talk to your doctor.
  • shaking or tremors - talk to your doctor if this is bothering you. These symptoms can be a sign that the dose is too high for you. It may help to change your dose or take your medicine at a different time of day.
  • difficulty sleeping - talk to your doctor.
  • diarrhoea - drink lots of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor. Speak to a doctor if symptoms get worse or last longer than a week.
  • feeling or being sick - stick to simple meals and do not eat rich or spicy food. It might help to take your Medotrigin after a meal or snack. If you're being sick, take small, frequent sips of water or squash to avoid dehydration. Speak to a doctor if symptoms get worse or last longer than a week.

What should I avoid while taking Medotrigin?

Avoid driving or hazardous activity until you know how Medotrigin will affect you. Your reactions could be impaired.

Important: your doctor will discuss with you the possibility that Medotrigin can cause blood disorders and allergic skin reactions. Although these occur much less commonly than the side-effects listed above, it is important that you contact your doctor straightaway if you experience any of the following symptoms:

  • A high temperature or swollen glands.
  • Extreme tiredness.
  • Unexplained bruising or bleeding.
  • A severe skin rash.

If you experience any other symptoms which you think may be due to Medotrigin, speak with your doctor or pharmacist for further advice.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Serious skin rashes called Stevens-Johnson syndrome and toxic epidermal necrolysis. Symptoms can include:
    • blistering or peeling of your skin
    • hives
    • rash
    • painful sores in your mouth or around your eyes
  • fever
  • rash
  • swollen lymph glands
  • severe muscle pain
  • frequent infections
  • swelling of your face, eyes, lips, or tongue
  • unusual bruising or bleeding
  • weakness or tiredness
  • yellowing of your skin or the white part of your eyes
  • tiredness
  • weakness
  • frequent infections or an infection that won’t go away
  • unexplained bruising
  • nosebleeds
  • bleeding from the gums
  • thoughts about killing yourself
  • attempts to harm or kill yourself
  • depression or anxiety that’s new or gets worse
  • restlessness
  • panic attacks
  • trouble sleeping
  • anger
  • aggressive or violent behavior
  • crankiness that’s new or gets worse
  • dangerous behavior or impulses
  • extreme increase in activity and talking
  • headache
  • fever
  • nausea and vomiting
  • stiff neck
  • rash
  • being more sensitive to light than usual
  • muscle pains
  • chills
  • confusion
  • drowsiness
  • high fever, typically over 101°F
  • rash
  • enlarged lymph nodes
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Medotrigin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Medotrigin are listed below.

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