Lirpan tablets

Lirpan

  • Active Ingredient: Donepezil
  • 10 mg, 5 mg
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What is Lirpan?

The active ingredient of Lirpan brand is donepezil. Donepezil improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah SEET il KOE leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning.

Used for

Lirpan is used to treat diseases such as: Alzheimer's Disease, Lewy Body Dementia, Mild Cognitive Impairment.

Side Effect

Possible side effects of Lirpan include: burning, prickling, or tingling sensations; troubled breathing; frequent urge to urinate; fatigue; frequent urination; stomach pain; hot flashes; chest pain or discomfort.

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There are no adequate data on the developmental risks associated with the use of ARICEPT in pregnant women. In animal studies, developmental toxicity was not observed when Lirpan was administered to pregnant rats and rabbits during organogenesis, but administration to rats during the latter part of pregnancy and throughout lactation resulted in increased stillbirths and decreased offspring survival at clinically relevant doses . In the U.S. general population, the estimated background risks of major birth defects and miscarriage in clinically recognized pregnancies are 2% to 4% and 15% to 20%, respectively. The background risks of major birth defects and miscarriage for the indicated population are unknown.

Oral administration of Lirpan to pregnant rats and rabbits during the period of organogenesis did not produce any teratogenic effects at doses up to 16 mg/kg/day (approximately 6 times the maximum recommended human dose of 23 mg/day on a mg/m² basis) and 10 mg/kg/day (approximately 7 times the MRHD on a mg/m² basis), respectively. Oral administration of Lirpan (1, 3, 10 mg/kg/day) to rats during late gestation and throughout lactation to weaning produced an increase in stillbirths and reduced offspring survival through postpartum day 4 at the highest dose. The no-effect dose of 3 mg/kg/day is approximately equal to the MRHD on a mg/m² basis.

How to use Lirpan HCL

Read the Patient Information Leaflet if available from your pharmacist before you start taking Lirpan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily just before bedtime. If you experience sleep problems (insomnia), talk to your doctor about switching to a morning dose.

If you are taking the 23-milligram strength tablets, swallow them whole. Do not split, crush, or chew these tablets. Doing so can increase the risk of side effects.

Dosage is based on your medical condition and response to treatment. To reduce your risk of side effects (such as nausea and diarrhea), your doctor will start this medication at a low dose and gradually increase your dose over weeks to months. Follow your doctor's instructions carefully. Do not increase your dose or use this drug more often than prescribed.

If you do not take Lirpan for 7 or more days in row, talk with your doctor before starting again. You may need to start at a lower dose to decrease the risk of side effects.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. Do not stop taking it unless your doctor instructs you to do so. It may take a several weeks before you get the full benefit of this drug.

Tell your doctor if your condition worsens.

Postmarketing Experience

Voluntary reports of adverse events temporally associated with Lirpan hydrochloride that have been received since market introduction that are not listed above, and for which there are inadequate data to determine the causal relationship with the drug include the following: abdominal pain, agitation, cholecystitis, confusion, convulsions, hallucinations, heart block (all types), hemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, and rash.

Severe Alzheimer’s Disease

Lirpan hydrochloride tablet has been shown to be effective in controlled clinical trials at doses of 10 mg administered once daily.

Drug forms and strengths

Generic: Lirpan

  • Form: oral tablet
  • Strengths: 5 mg, 10 mg, and 23 mg
  • Form: orally disintegrating tablet (ODT)
  • Strengths: 5 mg and 10 mg

Brand: Aricept

  • Form: oral tablet
  • Strengths: 5 mg, 10 mg, and 23 mg

Antifungal medications

When taken with Lirpan, these drugs can increase the level of Lirpan in your body. This can cause more side effects. Examples of these drugs include:

Mechanism of Action

Lirpan hydrochloride is a piperidine derivative and a centrally acting, rapid, reversible inhibitor of acetylcholinesterase. Acetylcholinesterase is an enzyme that degrades acetylcholine after it is released from the presynapse. Lirpan binds reversibly to acetylcholinesterase and inhibits the hydrolysis of acetylcholine, thus increasing the availability of acetylcholine at the synapses, enhancing cholinergic transmission. Some in vitro data has suggested that anticholinesterase activity of Lirpan is relatively specific for acetylcholinesterase in the brain. It is structurally unrelated to other anticholinesterase agents like tacrine and physostigmine.

Some noncholinergic mechanisms have also been proposed. Lirpan upregulates the nicotinic receptors in the cortical neurons, adding to neuroprotective property. It inhibits voltage-activated sodium currents reversibly and delays rectifier potassium currents and fast transient potassium currents, although this action is unlikely to contribute to clinical effects.


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