Ledopsan tablets


  • Active Ingredient: Carbidopa
  • 300 mg, 125 mg, 110 mg
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What is Ledopsan?

The active ingredient of Ledopsan brand is carbidopa. Carbidopa is used with another medicine called levodopa to treat the symptoms of Parkinson's disease (stiffness, tremors, spasms, poor muscle control). Symptoms of Parkinson's disease may be caused by low levels of a chemical called dopamine (DOE pa meen) in the brain.

Used for

Ledopsan is used to treat diseases such as: GTP-CH Deficiency, Neuroleptic Malignant Syndrome, Parkinsonian Tremor.

Side Effect

Possible side effects of Ledopsan include: Upset stomach or throwing up.; Throwing up blood or throw up that looks like coffee grounds.; A burning, numbness, or tingling feeling that is not normal.; Feeling sleepy.; Signs of high or low blood pressure like very bad headache or dizziness, passing out, change in eyesight..

How to Buy Ledopsan tablets online?

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What other drugs will affect Sinemet?

Other drugs may interact with Ledopsan and levodopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is the dosage for levodopa-Ledopsan?

Ledopsan-levodopa is taken several times per day. It may be administered with food to reduce the likelihood of nausea; however, a high-protein diet may reduce its absorption. The initial dose using regular tablets is 25/100 mg three times daily. The dose may be increased by one tablet every day or every other day until 8 tablets of 25/100 mg daily is reached. Alternatively 10/100 mg three or four times daily may be used initially and increased by one tablet daily or every other day until a total of eight tablets daily is reached. The dose of controlled release tablets is 50/200 mg twice daily and may increase up to 1.6 grams levodopa daily. Controlled release tablet should be given at least 6 hours apart.


Ledopsan and Levodopa extended-release tablet contains Ledopsan and Levodopa in a 1:4 ratio as either the 25 mg/100 mg tablet or the 50 mg/200 mg tablet. The daily dosage of Ledopsan and Levodopa extended-release tablets must be determined by careful titration. Patients should be monitored closely during the dose adjustment period, particularly with regard to appearance or worsening of involuntary movements, dyskinesias or nausea. Ledopsan and Levodopa extended-release tablets should not be chewed or crushed.

Standard drugs for Parkinson’s disease, other than levodopa without a decarboxylase inhibitor, may be used concomitantly while Ledopsan and Levodopa extended-release tablet is being administered, although their dosage may have to be adjusted.

Since carb >6 ). Initial Dosage

Patients currently treated with conventional Ledopsan levodopa preparations: Studies show that peripheral dopa-decarboxylase is saturated by the bioavailable carb >

Table 2: Approximate Bioavailabilities at Steady State *

Why is this medication prescribed?

The combination of levodopa and Ledopsan is used to treat the symptoms of Parkinson's disease and Parkinson's-like symptoms that may develop after encephalitis (swelling of the brain) or injury to the nervous system caused by carbon monoxide poisoning or manganese poisoning. Parkinson's symptoms, including tremors (shaking), stiffness, and slowness of movement, are caused by a lack of dopamine, a natural substance usually found in the brain. Levodopa is in a class of medications called central nervous system agents. It works by being converted to dopamine in the brain. Ledopsan is in a class of medications called decarboxylase inhibitors. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.

Drug Interactions

Caution should be exercised when the following drugs are administered concomitantly with Ledopsan and Levodopa extended-release tablets .

Symptomatic postural hypotension has occurred when Ledopsan levodopa preparations were added to the treatment of patients receiving some antihypertensive drugs. Therefore, when therapy with Ledopsan and Levodopa extended-release tablet is started, dosage adjustment of the antihypertensive drug may be required.

For patients receiving MAO inhibitors (Type A or B), see CONTRAINDICATIONS. Concomitant therapy with selegiline and Ledopsan levodopa may be associated with severe orthostatic hypotension not attributable to Ledopsan levodopa alone (see CONTRAINDICATIONS).

There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and Ledopsan levodopa preparations.

Dopamine D 2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of levodopa. In addition, the beneficial effects of levodopa in Parkinson’s disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with Ledopsan and Levodopa extended-release tablets should be carefully observed for loss of therapeutic response.

Use of Ledopsan and Levodopa extended-release tablets with dopamine-depleting agents (e.g., reserpine and tetrabenazine) or other drugs known to deplete monoamine stores is not recommended.

Ledopsan and Levodopa extended-release tablets and iron salts or multivitamins containing iron salts should be coadministered with caution. Iron salts can form chelates with levodopa and Ledopsan and consequently reduce the bioavailability of Ledopsan and levodopa.

Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.

What should I avo >

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid taking iron supplements or eating a diet that is high in protein (protein sources include meat, eggs, and cheese). These things can make it harder for your body to digest and absorb Ledopsan and levodopa. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medicine.

How should I take Ledopsan?

Follow all directions on your prescription label. Do not take Ledopsan in larger or smaller amounts or for longer than recommended.

Take both Ledopsan and levodopa at the same time.

If you already take levodopa but have never taken Ledopsan before, start taking both medicines at least 12 hours after you last took levodopa by itself.

Use Ledopsan with levodopa regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

While using this medicine, you may need frequent blood tests. Your heart, kidney function, and liver function may also need to be checked.

It may take up to several weeks of using Ledopsan with levodopa before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after a few weeks of treatment. Also tell your doctor if the effects of this medication seem to wear off quickly in between doses.

Do not stop using Ledopsan suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Ledopsan with levodopa.

Store at room temperature away from moisture and heat.

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