1. "Product Information. Xalatan (Latanox ophthalmic)." Pharmacia and Upjohn, Kalamazoo, MI.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Sensitivity to light
- Eye pain or irritation
- Trouble seeing or vision loss
- eye itching or redness
- eye tearing or crusting
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Latanox ophthalmic solution can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Latanox are listed below.
It is not known whether this drug or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Latanox Ophthalmic Solution is administered to a nursing woman.
The following reactions have been identified during postmarketing use of Latanox Ophthalmic Solution in clinical practice. Because they are reported voluntarily from a population of unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to Latanox Ophthalmic Solution, or a combination of these factors, include:
Nervous System Disorders: Dizziness; headache; toxic epidermal necrolysis
Eye Disorders: Eyelash and vellus hair changes of the eyelid (increased length, thickness, pigmentation, and number of eyelashes); keratitis; corneal edema and erosions; intraocular inflammation (iritis/uveitis); macular edema, including cystoid macular edema; trichiasis; periorbital and lid changes resulting in deepening of the eyelid sulcus; iris cyst; eyelid skin darkening; localised skin reaction on the eyelids; conjunctivitis; pseudopemphigoid of the ocular conjunctiva
Respiratory, Thoracic and Mediastinal Disorders: Asthma and exacerbation of asthma; dyspnea
Skin and Subcutaneous Tissue Disorders: Pruritus
Infections and Infestations: Herpes keratitis
Cardiac Disorders: Angina; palpitations; angina unstable
General Disorders and Administration Site Conditions: Chest pain
Do not give at late evening; may cause insomnia.
May impair ability to drive and/or operate heavy machinery.
- See "What Are Side Effects Associated with Using Latanox?"
What do I need to tell my doctor BEFORE I take Latanox Eye Drops?
- If you have an allergy to Latanox or any other part of this medicine (Latanox eye drops).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have swelling in the eye.
- If you have a herpes infection of the eye.
- If you are using another drug like this one. If you are not sure, ask your doctor or pharmacist.
This is not a list of all drugs or health problems that interact with this medicine (Latanox eye drops).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (Latanox eye drops) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
More common side effects
The more common side effects of Latanox can include:
- changes in your eye color
- changes in the thickness, length, or color of your eyelashes
- darkening of the skin around your eyes
- blurred vision
- burning or stinging
- dry eyes
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
How it works
Latanox belongs to a class of drugs called prostaglandin inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Latanox works by lowering the pressure in your eyes. It does this by helping to increase the natural flow of fluids out of your eye.
Latanox ophthalmic solution can cause certain side effects.
Elevated Baseline IOP
Patients with mean baseline IOP of 24-25 mmHg who were treated for 6 months in multi-center, randomized, controlled trials demonstrated 6-8 mmHg reductions in IOP. This IOP reduction with Latanox Ophthalmic Solution 0.005% dosed once daily was equivalent to the effect of timolol 0.5% dosed twice daily.
Latanox Ophthalmic Dosage
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
The usual dose of this medicine is 1 drop into the affected eye every evening. Follow your doctor's dosing instructions very carefully.
Do not use this medicine while wearing contact lenses. Latanox ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.
Wash your hands before using the eye drops.
To apply the eye drops:
- Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.
- Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.
- Wait at least 5 minutes before using any other eye drops your doctor has prescribed.
Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.
Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.
Tell your doctor right away if you have an eye injury or eye infection, or if you plan to have eye surgery.
Store an unopened bottle of Latanox eye drops in a refrigerator. Do not freeze.
After your first use, store the eye drops at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Throw away the medicine after 6 weeks have passed since you first opened the bottle.
An overdose of Latanox ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.
Skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.
Copyright 1996-2019 Cerner Multum, Inc.
Latest Update: 11/9/2018, Version: 9.01
How Supplied/Storage and Handling
Latanox Ophthalmic Solution is a sterile, clear, isotonic, buffered, preserved colorless solution of Latanox 0.005% (50 mcg/mL). It is available as a 2.5 mL solution in a 5 mL natural low density polyethylene bottle with a low density polyethylene dropper tip, a turquoise high density polyethylene screw cap and a tamper-evident seal.
Patient Counseling Information
Potential for Pigmentation: Advise patients about the potential for increased brown pigmentation of the iris, which may be permanent. Inform patients about the possibility of eyel >see Warnings and Precautions (5.1) ].
Potential for Eyelash Changes: Inform patients of the possibility of eyelash and vellus hair changes in the treated eye during treatment with Latanox Ophthalmic Solution. These changes may result in a disparity between eyes in length, thickness, pigmentation, number of eyelashes or vellus hairs, and/or direction of eyelash growth. Eyelash changes are usually reversible upon discontinuation of treatment.
Handling the Container: Instruct patients to avo >see Warnings and Precautions (5.6) ].
When to Seek Physician Advice: Advise patients that if they develop an intercurrent ocular condition (e.g., trauma or infection) or have ocular surgery, or develop any ocular reactions, particularly conjunctivitis and eyelid reactions, they should immediately seek their physician's advice concerning the continued use of the multiple-dose container.
Use with Contact Lenses: Advise patients that Latanox Ophthalmic Solution contains benzalkonium chloride, which may be absorbed by contact lenses. Contact lenses should be removed prior to administration of the solution. Lenses may be reinserted 15 minutes following administration of Latanox Ophthalmic Solution.
Use with Other Ophthalmic Drugs: If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart.
Administration of amphetamine for prolonged periods of time may lead to drug dependence and must be avoided.
- See "What Are Side Effects Associated with Using Latanox?"
What are some other side effects of Latanox Eye Drops?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Eye irritation.
- Blurred eyesight.
- Eyelash growth.
- Feeling that something is in the eye.
- This medicine may cause eyelash changes like dark eyelashes, thickness, or more eyelashes. Most of the time, these changes go back to normal after this medicine (Latanox eye drops) is stopped.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.