Off-label & Investigational uses
- fibromyalgia 5
- bipolar disorder 8, 30
- postoperative analgesic 9
- migraine prophylaxis 10
- headache 31
- postmenopausal hot flashes 12
- interstitial cystitis (IC) 13
- painful diabetic neuropathy 14, 15
- social phobia 16
- depression 18
- panic disorder 19
- essential tremor 20
- generalized tonic-clonic seizures
- restless legs syndrome (RLS) 21, 22
- insomnia 23
- posttraumatic stress disorder (PTSD) 17
- irritable bowel syndrome (IBS) 24
- trigeminal neuralgia 25
- alcohol dependence 36
- refractory chronic cough 11
- postoperative nausea and vomiting 1
- itching (pruritus) 37
Gabatin for Fibromyalgia Gabatin (1200-2400 mg per day) is safe and effective for the treatment of pain and other symptoms associated with fibromyalgia. In a 12-week, randomized, double-blind study a significantly greater proportion of Gabatin-treated patients achieved response than placebo-treated patients (51% versus 31%). Gabatin compared with placebo also significantly improved the BPI average pain interference score, the Fibromyalgia Impact Questionnaire total score, the Clinical Global Impression of Severity, the Patient Global Impression of Improvement, the Medical Outcomes Study Sleep Problems Index , but not the mean tender point pain threshold or the Montgomery Asberg Depression Rating Scale 5 .
Gabatin for Bipolar disorder Evidence suggests that it may have mood-stabilizing and possibly antidepressant properties in bipolar depression. However, Gabatin off-label use for bipolar disorder is increasingly controversial.
Gabatin may have a role as adjunctive agent in the treatment of patients with bipolar disorders when complicated by co-morb >29 .
Small, randomized clinical trial comparing the prophylactic efficacy of adjunctive Gabatin to placebo has shown that, despite lack of acute efficacy, treatment with Gabatin may prov >3 .
In small, uncontrolled, heterogeneous study Gabatin, either alone or as an adjunct, appeared moderately effective for depressive and manic symptoms 28 .
The findings of placebo-controlled study d >4 .
Dosage for Bipolar disorder: The dosage in clinical trials examining Gabatin for mood stabilization ranged from 900 mg to 2400 mg per day in 3 divided doses.
Gabatin for restless leg syndrome (RLS) Restless legs syndrome is a disorder characterized by sensory and motor symptoms in the legs that is best treated with dopaminergic drugs and opiates. RLS is often difficult to treat. Gabatin provides a well-tolerated and effective treatment of RLS. It improves sensory and motor symptoms in RLS and also improves sleep.
In clinical study Gabatin was associated with reduced symptoms on RLS Rating Scale, Clinical Global Impression, pain analogue scale, and Pittsburgh Sleep Quality Index. Also, studies showed significantly reduced periodic leg movements during sleep and improved sleep architecture (increased total sleep time, sleep efficiency, and slow wave sleep, and decreased stage 1 sleep). Patients whose symptoms included pain benefited most from Gabatin 22 .
Kidney problems: If you are older than 12 years and have kidney problems or are on hemodialysis, your dose of Gabatin will need to be changed. This will be based on how well your kidneys are working.
Gabatin oral capsule comes with several warnings. Call your doctor if you start having more seizures or a different kind of seizure while taking this drug.
Q: Can I safely take Gabatin on an "as needed" basis? I don't want to gain weight and I cannot afford it on an ongoing basis. Is there another drug that I can take as needed that will do the same thing as this one with no weight gain side effects? I am also a diabetic and I take metformin every day. I have fibromyalgia and I take hydrocodone for that and Flexeril for muscle pain.
A: Gabatin is in a drug class called anticonvulsants. Gabatin is used in people who have epilepsy to control certain types of seizures. Additionally, Gabatin is used to treat pain from postherpetic neuralgia, which includes pains and aches that last for months to years after being inflicted with shingles. Gabatin works to reduce seizures by reducing abnormal excitement in the brain. Gabatin works in relieving pain by altering the way the body senses pain. Gabatin may be used for other conditions not mentioned here. Weight gain and weight loss are both reported as side effects with Gabatin.
Gabatin pharmacokinetics were determined in 48 pediatric subjects between the ages of 1 month and 12 years following a dose of approximately 10 mg/kg. Peak plasma concentrations were similar across the entire age group and occurred 2 to 3 hours postdose. In general, pediatric subjects between 1 month and 60 mL/min) to 52 hours (creatinine clearance 60 mL/min group) to about 10 mL/min (
Missed Dose of Gabatin
Take Gabatin exactly as directed by your doctor.
Do not stop taking Gabatin on your own because stopping suddenly can cause withdrawal symptoms.
If you miss a dose of Gabatin, take the missed dose as soon as you remember.
If it's almost time for your next dose, skip the missed dose. Don't double your dose to make up for a missed dose.thoughts of suic >
Gabatin oral capsule can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.
Below is a list of medications that can interact with Gabatin. This list does not contain all drugs that may interact with Gabatin.
Before taking Gabatin, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
What should I do if I forget a dose?
If you forget to take Gabatin capsules, tablets, or oral solution, take the missed dose as soon as you remember it. However, if it is almost time for the next dose or if you forget to take Gabatin extended-release tablets, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Some people have thoughts about suicide while taking this medicine. Children taking Gabatin may have behavior changes. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Do not stop using Gabatin suddenly, even if you feel fine.
Before taking Gabatin, tell your doctor or pharmacist if you are allergic to it; or to Gabatin enacarbil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, mental/mood problems (such as depression, thoughts of suicide), use/abuse of drugs/alcohol, breathing problems.
This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of this drug, especially swelling of the hands/ankles/feet, slow/shallow breathing, dizziness, or loss of coordination. Dizziness and loss of coordination can increase the risk of falling.
Children may be more sensitive to the side effects of this drug, especially mental/mood/behavior changes (such as hostility, problems concentrating, restlessness).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Gabatin passes into breast milk. Consult your doctor before breast-feeding.
Which drugs or supplements interact with this drug?
- Antacids reduce the concentration of Gabatin in blood. Therefore, Gabatin should be administered 2 hours or more after taking antacids.
- Morphine significantly increases blood concentrations of Gabatin and may increase central nervous system-related adverse events associated with Gabatin.
Estimates of steady-state pharmacokinetic parameters for phenobarbital or Gabatin (300 mg three times a day; N=12) are identical whether the drugs are administered alone or together.
Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of Gabatin (400 mg three times a day; N=13). The Cmax of norethindrone was 13% higher when it was coadministered with Gabatin; this interaction is not expected to be of clinical importance.
Probenecid is a blocker of renal tubular secretion. Gabatin pharmacokinetic parameters without and with probenecid were comparable. This indicates that Gabatin does not undergo renal tubular secretion by the pathway that is blocked by probenecid.
Rated Gabatin (Neurontin) for Neuropathic Pain Report
I was prescribed Gabatin for severe anxiety, panic attacks and depression. It is the only medicine that I've ever taken that completely took all of them away. I take 800mg three times a day. It just sucked my depression away and I've had ZERO panic attacks since I started taking it. Some will say Gabatin is not helpful for anxiety and depression, but they're wrong. Trust me, I've had crippling anxiety and depression for 25 years and have tried every SSRI, SNRI and benzo there is. Nothing worked even half as well as Gabatin does. If you suffer from an anxiety disorder, please give this medicine a shot. Everyone's different, so although I need 2400mg a day, you might only need 900mg. I've read that some people take as much as 4800mg per day to get good results. I'm so thankful my Dr prescribed this for me. I have my life back. I also sleep much, much more soundly and longer. I used to wake up every two or three hours all night long. Now I sleep five or six hours straight, wake up top use the bathroom, then sleep a few more hours and wake up feeling refreshed. My OCD tics have also dramatically diminished. This drug is a miracle for anxiety!
What other information should I know?
Keep all appointments with your doctor.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Gabatin.
If you use a dipstick to test your urine for protein, ask your doctor which product you should use while taking this medication.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Rated Gabatin (Neurontin) for Postherpetic Neuralgia Report
I’ve recently been experiencing burning in my feet and legs. It was to the point that I couldn’t walk without serious consequences. I couldn’t rest my feet on my bed. I was waking up off and on all night in pain. Went to the ER because it was getting worse and the nerve pain was spreading. They prescribed Gabatin 100mg. I’ve only been on it two days so take this with a grain of salt but, it’s been an absolute miracle. Significant pain reduction, I’m able to do things again. I’m glad I gave it a shot even though I’d heard bad things. Everyone reacts differently. If you’re struggling, give it a shot.
From Nerve Pain Relief To Dog Seizures: What Is Gabatin Used For In Dogs
Gabatin for dogs has been discovered to have a wide range of important uses in canines.
One of the key uses of Gabatin in dogs is to help alleviate chronic pain conditions, such as arthritis pain.
When used in conjunction with opioid pain relievers or non-steroidal anti-inflammatory drugs, Gabatin has been shown to increase the efficacy of these, resulting in more effective pain relief for your dog.
It is also an important drug for post-surgery recovery in dogs, ensuring the animal’s pain is as minimal as possible while they heal from an operation or procedure.
If you have a dog that has epilepsy, then you may already know of Gabatin. Gabatin is particularly effective in preventing seizures in dogs due to epilepsy, which is a wonderful relief for owners with a pet that suffers from this worrying condition.
Gabatin for dogs is also emerging as an excellent solution for use in the anxiety of dogs, due to it having a calming effect on the nervous system.
Another excellent function of Gabatin for our furry friends is as a safe sedative in stressful situations, such as prior to surgery or a vet visit.
Dog seizures can be scary! Make sure you read Dog Seizures: Symptoms, Types, and Treatment for Seizures In Dogs! For more information.