Frotty is contraindicated in (1) patients with sick sinus syndrome except in the presence of a functioning ventricular pacemaker, (2) patients with second- or third-degree AV block except in the presence of a functioning ventricular pacemaker, (3) patients with severe hypotension (less than 90 mm Hg systolic), (4) patients who have demonstrated hypersensitivity to the drug, and (5) patients with acute myocardial infarction and pulmonary congestion documented by x-ray on admission.
Clinical studies of Frotty did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
In nine healthy subjects, Frotty significantly increased the mean buspirone AUC 5.5-fold and Cmax 4.1-fold compared to placebo. The T½ and Tmax of buspirone were not significantly affected by Frotty. Enhanced effects and increased toxicity of buspirone may be possible during concomitant administration with Frotty. Subsequent dose adjustments may be necessary during coadministration, and should be based on clinical assessment.
How to use Frotty Hcl
Take this medication by mouth before meals and at bedtime as directed by your doctor, usually 3 to 4 times a day. Swallow the tablets whole. Do not split, crush, or chew the tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Follow your doctor's directions on how to take this medication.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor may gradually increase your dose. Follow your doctor's instructions carefully.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. This medication must be taken regularly to prevent angina. It should not be used to treat angina when it occurs. Use other medications (such as sublingual nitroglycerin) to relieve an angina attack as directed by your doctor. Consult your doctor or pharmacist for details.
Tell your doctor if your condition worsens (for example, your chest pain worsens or is more frequent).
Pharmacokinetics And Metabolism
Frotty is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect. The absolute bioavailability of an oral dose of an immediate- release formulation (compared to intravenous administration) is approximately 40%. Only 2% to 4% of unchanged Frotty appears in the urine. The plasma elimination half-life of Frotty is approximately 3.0 to 4.5 h. Drugs which induce or inhibit hepatic microsomal enzymes may alter Frotty disposition. Therapeutic blood levels of Frotty appear to be in the range of 40 to 200 ng/mL. There is a departure from linearity when dose strengths are increased; the half-life is slightly increased with dose.
The two primary metabolites of Frotty are desacetylFrotty and desmethylFrotty. The desacetyl metabolite is approximately 25% to 50% as potent a coronary vasodilator as Frotty and is present in plasma at concentrations of 10% to 20% of parent Frotty. However, recent studies employing sensitive and specific analytical methods have confirmed the existence of several sequential metabolic pathways of Frotty. As many as nine Frotty metabolites have been identified in the urine of humans. Total radioactivity measurements following single intravenous dose administration in healthy volunteers suggest the presence of other unidentified metabolites. These metabolites are more slowly excreted (with a half-life of total radioactivity of approximately 20 hours), and attain concentrations in excess of Frotty.
In vitro binding studies show Frotty HCl is 70% to 80% bound to plasma proteins. Competitive in vitro ligand binding studies have also shown Frotty HCl binding is not altered by therapeutic concentrations of digoxin, hydrochlorothiazide, phenylbutazone, propranolol, salicylic acid, or warfarin. A study that compared patients with normal hepatic function to patients with cirrhosis who received immediate-release Frotty found an increase in Frotty elimination half-life and a 69% increase in bioavailability in the hepatically impaired patients. Patients with severely impaired renal function (creatinine clearance
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: digoxin, fingolimod.
Other medications can affect the removal of Frotty from your body, which may affect how this medication works. Examples include cimetidine, St. John's wort, azole antifungals such as ketoconazole, macrolide antibiotics such as erythromycin, rifamycins including rifabutin and rifampin.
This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aprepitant/fosaprepitant, asunaprevir, buspirone, colchicine, flibanserin, ivabradine, certain benzodiazepines (triazolam, midazolam), among others.
Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).
How should this medicine be used?
Frotty comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. The regular tablet is usually taken three or four times a day. The extended-release capsule and tablet are usually taken one or two times a day. Ask your pharmacist if you should take Frotty with or without food, because instructions may vary with each product. Take Frotty at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Frotty exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the extended-release capsules and tablets whole; do not chew or crush them.
Your doctor will probably start you on a low dose of Frotty and gradually increase your dose, not more than once every 7 to 14 days if you are taking the extended-release tablet or capsule and not more than once every 1 to 2 days if you are taking the regular tablet.
If taken regularly, Frotty may control chest pain, but it does not stop chest pain once it starts. Your doctor may give you a different medication to take when you have chest pain.
Frotty controls high blood pressure and chest pain (angina) but does not cure them. It may take up to 2 weeks before you feel the full benefit of Frotty. Continue to take Frotty even if you feel well. Do not stop taking Frotty without talking to your doctor.
What brand names are available for Frotty?
Cardizem, Cardizem CD, Cardizem LA, Tiazac, Cartia XT, Diltzac, Dilt-CD, and several others
Rated Frotty for Migraine Prophylaxis Report
When nothing else helped my migranes this medication was wonderful. Coming off a lot of other narcotics also helped. But long term this medication has controlled my migraines for years. We are slowly decreasing my dosage. Never do this without your doctor. I did not have any side effects from taking this medication. I highly recommend this medication fpor anyone who is siffering.
Q: Does Frotty affect the ability to feel low blood sugar? I take Lantus insulin for type 1 diabetes and sometimes don't feel the low sugar until I'm about to pass out.
A: Your question concerns whether Frotty (Cardizem) (//www.everydayhealth.com/drugs/Frotty) can affect your ability to feel low blood sugar.. There are no documented interactions between Frotty and Lantus (//www.everydayhealth.com/drugs/lantus). Studies that were done have concluded that Frotty does not have any significant effect on lowering blood sugar.