The activity of FLONASE Nasal Spray is due to the parent drug, Flunase propionate. Due to the low bioavailability by the intranasal route, the majority of the pharmacokinetic data was obtained via other routes of administration.
Mechanism Of Action
Flunase propionate is a synthetic trifluorinated corticosteroid with anti-inflammatory activity. Flunase propionate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor that is 18 times that of dexamethasone, almost twice that of beclomethasone-17-monopropionate (BMP), the active metabolite of beclomethasone dipropionate, and over 3 times that of budesonide. Data from the McKenzie vasoconstrictor assay in man are consistent with these results. The clinical significance of these findings is unknown.
The precise mechanism through which Flunase propionate affects rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. In 7 trials in adults, FLONASE Nasal Spray has decreased nasal mucosal eosinophils in 66% of patients (35% for placebo) and basophils in 39% of patients (28% for placebo). The direct relationship of these findings to long-term symptom relief is not known.
When to call the doctor
- While using this drug, call your doctor or get medical care right away if:
- your breathing problems get worse
- you need to use your rescue inhaler more often than usual
- your rescue inhaler doesn’t work as well to relieve your symptoms
- you need to use 4 or more inhalations of your rescue inhaler in 24 hours for two or more days in a row
- you use one whole canister of your rescue inhaler in eight weeks
- your peak flow meter results decrease (your healthcare provider will tell you the numbers that are right for you)
- you have asthma and your symptoms don’t improve after using this drug regularly for one week
Flunase/salmeterol inhalation powder doesn’t cause drowsiness, but it can cause other side effects.
- fluted rolled glass
- fluted work
- Flutes of Chi
- Flutes of Chi
- Flunase furoate
- Flunase furoate
- Flunase propionate
- Flunase propionate
- Flunase propionate
- Flunase Propionate Aqueous Nasal Spray
- Flunase Propionate Nasal Drop
- Flunase proprionate
- Flunase proprionate
- Fluting iron
- Fluting lathe
- flutter (one's) eyelashes
Generic Name: Flunase propionate Dosage Form: nasal spray, metered
Medically reviewed by Drugs.com. Last updated on Jan 1, 2019.
Dryness and irritation, conjunctivitis, blurred vision, glaucoma, increased intraocular pressure, and cataracts.
Cases of growth suppression have been reported for intranasal corticosteroids, including FLONASE .
Read the entire FDA prescribing information for Flonase (Flunase Propionate Nasal Spray)
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Flunase is a preventer inhaler. Use it every day to prevent your symptoms from developing. Steroids like Flunase work by reducing the inflammation in your airways. When the inflammation has gone, your airways are much less likely to become narrow and cause symptoms such as wheezing.
Flunase is available on its own in an inhaler, and also in combination with other medicines, such as salmeterol, formoterol or vilanterol. These are medicines which also help to control the symptoms of asthma.
How Supplied/Storage and Handling
Flunase Propionate Nasal Spray USP, 50 mcg is supplied in an amber glass bottle fitted with a white metering atomizing pump, white nasal adapter fitted with a clear plastic dust cap, and a green safety clip, in a box of one (NDC 0054-3270-99) with FDA-approved Patient Labeling (see Patient Instructions for Use for proper actuation of the device). Each bottle contains a net fill weight of 16 g and will provide 120 actuations. Each actuation delivers 50 mcg of Flunase propionate in 100 mg of formulation through the nasal adapter. The correct amount of medication in each spray cannot be assured after 120 sprays even though the bottle is not completely empty. The bottle should be discarded when the labeled number of actuations has been used.
Store between 4° and 30°C (39° and 86°F).
Flunase Propionate Cream, USP 0.05% contains Flunase propionate , a synthetic fluorinated corticosteroid, for topical dermatologic use. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents.
Chemically, Flunase propionate is C 25 H 31 F 3 O 5 S. It has the following structural formula:
Getting the most from your treatment
- Flunase is a preventer inhaler which needs to be used regularly in order to have an effect. It takes a few days for the steroid in the inhaler to build up its effect.
- Flunase inhalers will not give you immediate relief if you are having an asthma attack - you will need to use a reliever inhaler to ease the symptoms of an attack.
- If after using the inhaler for the first time your breathing becomes worse or you suddenly start to wheeze, let your doctor know straightaway. Your doctor will want to change the type of inhaler to one more suited to you.
- It is helpful to remember the colour of your inhaler and the brand name. This might be important if you need to see a doctor who does not have your medical records (such as if you are on holiday or if it is outside the normal opening hours of your GP surgery).
- Keep your regular appointments with your doctor or asthma clinic. This is so your doctor can review your treatment. If at any time you find that your asthma symptoms are getting worse or that you need to use a reliever inhaler more regularly, contact your doctor or nurse for advice straightaway.
- If you are using a high dose of Flunase, you will also be given a steroid card. You are advised to carry the card with you at all times in case you need any treatment by a doctor who does not have your medical records available.
- Continue to use your Flunase inhaler regularly. Do not stop using it abruptly, as this can make you feel unwell and cause your symptoms to return suddenly.
- Do not smoke. Smoking can cause severe irritation and damage to your lungs. It will make your condition worse and will reduce the beneficial effects of your inhalers.
- If you have diabetes, tell your doctor if you notice any change in your blood glucose tests, as Flunase may affect the levels of sugar in your blood.
How to use Flunase PROPIONATE Spray, Suspension
If you are using the over-the-counter product to self-treat, read and follow all directions on the product package before using this medication. If your doctor has prescribed this medication, read the Patient Information Leaflet before you start using Flunase and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Use this medication in the nose as directed by your doctor or the product package, usually once or twice a day. Do not spray in your eyes.
Gently blow your nose before using this drug. Shake the container gently before each use. Follow the instructions on how to properly prime the bottle if you are using it for the first time or if you have not used it for a week or longer.
The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or use this drug more often or for longer than directed. Your condition will not improve any faster, and your risk of side effects will increase. You may be directed to start with a higher dose of this drug for the first several days until you have begun to feel better, then decrease your dose. Children may need to use this drug for a shorter amount of time to lower the risk of side effects. If a child is using the over-the-counter product, read the package information to see how long he/she should use it and when you should check with the doctor.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day.
Clean the applicator regularly. Keep track of the number of sprays used from the container. Discard the container after you have used the number of sprays on the package label.
This medication does not work right away. You may feel an effect as soon as 12 hours after starting treatment, but it may take several days before you get the full benefit. If your condition does not improve after 1 week, or if it worsens, stop using this medication and consult your doctor or pharmacist. If you think you may have a serious medical problem, get medical help right away.